Interleukin-12: Basic principles and clinical applications

Current Topics in Microbiology and Immunology

Volumn 238, Issue , 1999, Pages 57-78

  Trinchieri, G ^a   Scott, P ^b  

^a WISTAR INSTITUTE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 12; LEISHMANIA VACCINE;

CANCER IMMUNOTHERAPY; CYTOKINE PRODUCTION; HUMAN; IMMUNOREGULATION; INFECTION RESISTANCE; LEISHMANIASIS; LISTERIOSIS; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; PERTUSSIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; REVIEW; T LYMPHOCYTE ACTIVATION; VACCINATION; VACCINE PRODUCTION;

EID: 0032943010     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-662-09709-0_4     Document Type: Review

References (9)

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2. Aste-Amezaga M, D'Andrea A, Kubin M, Trinchieri G (1994) Cooperation of natural killer cell stimulatory factor/interleukin-12 with other stimuli in the induction of cytokines and cytotoxic cell-associated molecules in human T and NK cells. Cell Immunol 156:480-492
3. Bacon CM, McVicar DW, Ortaldo JR, Rees RC, O'Shea JJ, Johnston JA (1995a) Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of janus family tyrosine kinases by IL-2 and IL-12. J Exp Med 181:399-404
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7. Biron CA, Gazzinelli RT (1995) Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome. Curr Opin Immunol 7:485-496
8. Bliss J, Maylor R, Stokes K, Murray KS, Ketchum MA, Wolf SF (1996a) Interleukin-12 as vaccine adjuvant: Characteristics of primary, recall, and long-term resistance. Ann New York Acad Sci 795:26-35
9. Bliss J, Van Cleave V, Murray K, Wiencis A, Ketchum M, Maylor R, Haire T, Resmini C, Abbas AK, Wolf SF (1996b) IL-12 as an adjuvant, promotes a T helper I cell, but does not suppress a T helper 2 cell recall response. J Immunol 156:887-894