Structure-based mutagenesis approaches toward expanding the substrate specificity of D-2-deoxyribose-5-phosphate aldolase

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 1, 2003, Pages 43-52

  DeSantis, Grace ^a,c   Liu, Junjie ^a   Clark, David P ^b   Heine, Andreas ^a   Wilson, Ian A ^a   Wong, Chi Huey ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c DIVERSA CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AZIDOPROPINALDEHYDE; ALDEHYDE; ALDEHYDE DERIVATIVE; ATORVASTATIN; DEOXYRIBOSE; DEXTRO 2 DEOXYRIBOSE; DEXTRO 2 DEOXYRIBOSE 5 PHOSPHATE ALDOLASE; EPOTHILONE DERIVATIVE; FRUCTOSE BISPHOSPHATE ALDOLASE; HYPOCHOLESTEROLEMIC AGENT; LACTONE; UNCLASSIFIED DRUG;

ALDOL REACTION; ARTICLE; BACTERIAL STRAIN; CATALYST; CRYSTAL STRUCTURE; ENANTIOSELECTIVITY; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ESCHERICHIA COLI; MUTAGENESIS; SITE DIRECTED MUTAGENESIS; STEREOCHEMISTRY; WILD TYPE;

ALDEHYDE-LYASES; ALDEHYDES; BINDING SITES; CATALYSIS; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DEOXYRIBOSE; ESCHERICHIA COLI; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0037413355     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00429-7     Document Type: Article

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