Redesigning enzyme topology by directed evolution

Science

Volumn 279, Issue 5358, 1998, Pages 1958-1961

  MacBeath, Gavin ^a   Kast, Peter ^a   Hilvert, Donald ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHORISMATE MUTASE;

ARTICLE; CATALYSIS; DIRECTED MOLECULAR EVOLUTION; ENZYME MODIFICATION; POINT MUTATION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CHORISMATE MUTASE; CIRCULAR DICHROISM; CLONING, MOLECULAR; DIMERIZATION; DIRECTED MOLECULAR EVOLUTION; ESCHERICHIA COLI; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; TRANSFORMATION, BACTERIAL;

EID: 0032549781     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.279.5358.1958     Document Type: Article

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