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Volumn 20, Issue 3, 2003, Pages 173-185

New antileukemic agents

Author keywords

DNA hypomethylators; Farnesyl transferase; Inhibitors; Kinase inhibitors; Monoclonal antibodies; Nucleoside analogs

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 5 AZA 2' DEOXYCYTIDINE; ALETUZUMAB; ANGIOGENESIS INHIBITOR; ANTILEUKEMIC AGENT; CYTARABINE; FLT3 LIGAND; FLUDARABINE; GEMTUZUMAB OZOGAMICIN; GUANINE ARABINOSIDE; IMATINIB; INTERFERON; MIDOSTAURIN; MONOCLONAL ANTIBODY; NELARABINE; NUCLEOSIDE DERIVATIVE; PK 1166; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN KINASE INHIBITOR; PYRROLE DERIVATIVE; SEMAXANIB; SEMIXANIB; TIPIFARNIB; TROXACITABINE; UNCLASSIFIED DRUG; VATALANIB;

EID: 0037395237     PISSN: 08880018     EISSN: None     Source Type: Journal    
DOI: 10.1080/08880010390158928     Document Type: Review
Times cited : (1)

References (70)
  • 1
    • 0036147075 scopus 로고    scopus 로고
    • Novel agents for the therapy of acute leukemia
    • Giles FJ. Novel agents for the therapy of acute leukemia. Curr Opin Oncol. 2002;14:3-9.
    • (2002) Curr Opin Oncol , vol.14 , pp. 3-9
    • Giles, F.J.1
  • 2
    • 0032572912 scopus 로고    scopus 로고
    • Acute lymphoblastic leukemia
    • Pui CH, Evans WE. Acute lymphoblastic leukemia. N Engl J Med. 1998;339:605-615.
    • (1998) N Engl J Med , vol.339 , pp. 605-615
    • Pui, C.H.1    Evans, W.E.2
  • 3
    • 0034788453 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors: From rational design to clinical trials
    • Traxler P, Bold G, Buchdunger E, et al. Tyrosine kinase inhibitors: from rational design to clinical trials. Med Res Rev. 2001;21:499-512.
    • (2001) Med Res Rev , vol.21 , pp. 499-512
    • Traxler, P.1    Bold, G.2    Buchdunger, E.3
  • 4
    • 0037186924 scopus 로고    scopus 로고
    • Imatinib mesylate: A new oral targeted therapy
    • Savage DG, Antman KH. Imatinib mesylate: a new oral targeted therapy. N Engl J Med. 2002;346:683-693.
    • (2002) N Engl J Med , vol.346 , pp. 683-693
    • Savage, D.G.1    Antman, K.H.2
  • 5
    • 0033987746 scopus 로고    scopus 로고
    • Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia
    • Druker BJ, Lydon NB. Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia. J Clin Invest. 2000;105:3-7.
    • (2000) J Clin Invest , vol.105 , pp. 3-7
    • Druker, B.J.1    Lydon, N.B.2
  • 6
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the bcr-abl tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the bcr-abl tyrosine kinase in chronic myeloid leukemia. N Engl J Med. 2001;344:1031-1037.
    • (2001) N Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 7
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the bcr-abl tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • Druker BJ, Sawyers CL, Kantarjian H, et al. Activity of a specific inhibitor of the bcr-abl tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med. 2001;344:1038-1042.
    • (2001) N Engl J Med , vol.344 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3
  • 8
    • 0034868659 scopus 로고    scopus 로고
    • Signal transduction inhibition: Results from phase I clinical trials in chronic myeloid leukemia
    • Druker B. Signal transduction inhibition: results from phase I clinical trials in chronic myeloid leukemia. Semin Hematol. 2001;38(3 Suppl 8):9-14.
    • (2001) Semin Hematol , vol.38 , Issue.3 SUPPL. 8 , pp. 9-14
    • Druker, B.1
  • 9
    • 0037085785 scopus 로고    scopus 로고
    • Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myelogenous leukemia: Results of a phase 2 study
    • Talpaz M, Silver RT, Druker BJ, et al. Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myelogenous leukemia: results of a phase 2 study. Blood. 2002;99:1928-1937.
    • (2002) Blood , vol.99 , pp. 1928-1937
    • Talpaz, M.1    Silver, R.T.2    Druker, B.J.3
  • 10
    • 4243633069 scopus 로고    scopus 로고
    • Gleevec[™]: An active drug in patients with Ph+ chronic myeloid leukemia in accelerated phase: Updated results of a phase II study
    • abstract 3509
    • Talpaz M, Silver RT, Druker B, et al. Gleevec[™]: an active drug in patients with Ph+ chronic myeloid leukemia in accelerated phase: updated results of a phase II study. Proc Am Soc Hematol. 2001; abstract 3509.
    • (2001) Proc Am Soc Hematol
    • Talpaz, M.1    Silver, R.T.2    Druker, B.3
  • 11
    • 0010301291 scopus 로고    scopus 로고
    • Gleevec/Glivec (imatinib mesylate, STI-571) in patients with chronic myeloid leukemia in myeloid blast crisis: Updated results of a phase II study
    • abstract 3510
    • Sawyers CL, Hochhaus A, Feldman E, et al. Gleevec/Glivec (imatinib mesylate, STI-571) in patients with chronic myeloid leukemia in myeloid blast crisis: updated results of a phase II study. Proc Am Soc Hematol. 2001; abstract 3510.
    • (2001) Proc Am Soc Hematol
    • Sawyers, C.L.1    Hochhaus, A.2    Feldman, E.3
  • 12
    • 0037094118 scopus 로고    scopus 로고
    • In vitro effects of STI571-containing drug combinations on the growth of Philadelphia-positive chronic myelogenous leukemia cells
    • Scappini B, Onida F, Kantarjian HM, et al. In vitro effects of STI571-containing drug combinations on the growth of Philadelphia-positive chronic myelogenous leukemia cells. Cancer. 2002;94:2653-2662.
    • (2002) Cancer , vol.94 , pp. 2653-2662
    • Scappini, B.1    Onida, F.2    Kantarjian, H.M.3
  • 13
    • 0036683409 scopus 로고    scopus 로고
    • Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336
    • Hoover RR, Mahon FX, Melo JV, Daley GQ. Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336. Blood. 2002;100:1068-1071.
    • (2002) Blood , vol.100 , pp. 1068-1071
    • Hoover, R.R.1    Mahon, F.X.2    Melo, J.V.3    Daley, G.Q.4
  • 14
    • 0036534203 scopus 로고    scopus 로고
    • Simultaneous homoharringtonine and interferon-alpha in the treatment of patients with chronic-phase chronic myelogenous leukemia
    • O'Brien S, Talpaz M, Cortes J, et al. Simultaneous homoharringtonine and interferon-alpha in the treatment of patients with chronic-phase chronic myelogenous leukemia. Cancer. 2002;94:2024-2032.
    • (2002) Cancer , vol.94 , pp. 2024-2032
    • O'Brien, S.1    Talpaz, M.2    Cortes, J.3
  • 15
    • 0034161460 scopus 로고    scopus 로고
    • Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification
    • le Coutre P, Tassi E, Varella-Garcia M, et al. Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification. Blood. 2000;95:1758-1766.
    • (2000) Blood , vol.95 , pp. 1758-1766
    • Le Coutre, P.1    Tassi, E.2    Varella-Garcia, M.3
  • 16
    • 0034210577 scopus 로고    scopus 로고
    • Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cells
    • Weisberg E, Griffin JD. Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cells. Blood. 2000;95:3498-3505.
    • (2000) Blood , vol.95 , pp. 3498-3505
    • Weisberg, E.1    Griffin, J.D.2
  • 17
    • 0034254368 scopus 로고    scopus 로고
    • Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: Diverse mechanism of resistance
    • Mahon FX, Deininger MW, Schultheis B, et al. Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanism of resistance. Blood. 2000;96:1070-1079.
    • (2000) Blood , vol.96 , pp. 1070-1079
    • Mahon, F.X.1    Deininger, M.W.2    Schultheis, B.3
  • 18
    • 0034684075 scopus 로고    scopus 로고
    • Role of alpha1 acid glycoprotein in the in vivo resistance of human BCR-ABL(1) leukemic cells to the abl inhibitor STI571
    • Gambacorti-Passerini C, Barni R, le Coutre P, et al. Role of alpha1 acid glycoprotein in the in vivo resistance of human BCR-ABL(1) leukemic cells to the abl inhibitor STI571. J Natl Cancer Inst. 2000;92:1641-1650.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1641-1650
    • Gambacorti-Passerini, C.1    Barni, R.2    Le Coutre, P.3
  • 19
    • 0036398414 scopus 로고    scopus 로고
    • Mutation in the ATP-binding site of BCR-ABL in a patient with chronic myeloid leukemia with increasing resistance to STI571
    • Barthe C, Gharbi MJ, Lagarde V, et al. Mutation in the ATP-binding site of BCR-ABL in a patient with chronic myeloid leukemia with increasing resistance to STI571. Br J Haematol. 2002;119:109-111.
    • (2002) Br J Haematol , vol.119 , pp. 109-111
    • Barthe, C.1    Gharbi, M.J.2    Lagarde, V.3
  • 20
    • 0036678472 scopus 로고    scopus 로고
    • Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop
    • Roumiantsev S, Shah NP, Gorre ME, et al. Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop. Proc Natl Acad Sci USA. 2002;99:10700-10705.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10700-10705
    • Roumiantsev, S.1    Shah, N.P.2    Gorre, M.E.3
  • 21
    • 0036493544 scopus 로고    scopus 로고
    • Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation
    • Hofmann WK, Jones LC, Lemp NA, et al. Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation. Blood. 2002;99:1860-1862.
    • (2002) Blood , vol.99 , pp. 1860-1862
    • Hofmann, W.K.1    Jones, L.C.2    Lemp, N.A.3
  • 22
    • 0036566540 scopus 로고    scopus 로고
    • High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid-leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
    • Branford S, Rudzki Z, Walsh S, et al. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid-leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood. 2002;99:3472-3475.
    • (2002) Blood , vol.99 , pp. 3472-3475
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3
  • 23
    • 0036682481 scopus 로고    scopus 로고
    • Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment
    • Roche-Lestienne C, Soenen-Cornu V, Grardel-Duflos N, et al. Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment. Blood. 2002;100:1014-1018.
    • (2002) Blood , vol.100 , pp. 1014-1018
    • Roche-Lestienne, C.1    Soenen-Cornu, V.2    Grardel-Duflos, N.3
  • 24
    • 85038458615 scopus 로고    scopus 로고
    • Multiple resistance mechanisms identified through studies of cell lines derived from chronic myelogenous leukemia patients progressing on IMATINIB/STI571 therapy
    • abstract 3206
    • Donato NJ, Ji Wu JY, Alitar M, et al. Multiple resistance mechanisms identified through studies of cell lines derived from chronic myelogenous leukemia patients progressing on IMATINIB/STI571 therapy. Proc Am Soc Hematol. 2001; abstract 3206.
    • (2001) Proc Am Soc Hematol
    • Donato, N.J.1    Ji Wu, J.Y.2    Alitar, M.3
  • 25
    • 0003275899 scopus 로고    scopus 로고
    • STI571 in the treatment of pediatric Philadelphia (Ph+) chromosome-positive leukemia: A Children's Oncology Group phase 1 study (P-9973)
    • abstract 1466
    • Champagne MA, Hershon L, Rosamilia M, et al. STI571 in the treatment of pediatric Philadelphia (Ph+) chromosome-positive leukemia: a Children's Oncology Group phase 1 study (P-9973). Proc Am Soc Clin Oncol. 2001; abstract 1466.
    • (2001) Proc Am Soc Clin Oncol
    • Champagne, M.A.1    Hershon, L.2    Rosamilia, M.3
  • 26
    • 0035383768 scopus 로고    scopus 로고
    • FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia
    • Stirewalt DL, Kopecky KJ, Meshinchi S, et al. FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia. Blood. 2001;97:3589-3595.
    • (2001) Blood , vol.97 , pp. 3589-3595
    • Stirewalt, D.L.1    Kopecky, K.J.2    Meshinchi, S.3
  • 27
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood. 2001;98:1752-1759.
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3
  • 28
    • 0034040255 scopus 로고    scopus 로고
    • Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene
    • Rombouks WJ, Blokland I, Lowenberg B, et al. Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene. Leukemia. 2000;14:675-683.
    • (2000) Leukemia , vol.14 , pp. 675-683
    • Rombouks, W.J.1    Blokland, I.2    Lowenberg, B.3
  • 29
    • 0031686409 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
    • Kiyoi H, Towatari M, Yokota S, et al. Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia. 1998;12:1333-1337.
    • (1998) Leukemia , vol.12 , pp. 1333-1337
    • Kiyoi, H.1    Towatari, M.2    Yokota, S.3
  • 30
    • 0035871889 scopus 로고    scopus 로고
    • Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
    • Yamamoto Y, Kiyoi H, Nakano Y, et al. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood. 2001;97:2434-2439.
    • (2001) Blood , vol.97 , pp. 2434-2439
    • Yamamoto, Y.1    Kiyoi, H.2    Nakano, Y.3
  • 31
    • 0035437140 scopus 로고    scopus 로고
    • A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations
    • Levis M, Tse KF, Smith BD, et al. A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations. Blood. 2001;98:885-887.
    • (2001) Blood , vol.98 , pp. 885-887
    • Levis, M.1    Tse, K.F.2    Smith, B.D.3
  • 32
    • 0036624916 scopus 로고    scopus 로고
    • A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo
    • Levis M, Abllebach J, Tse KF, et al. A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo. Blood. 2002;99:3885-3891.
    • (2002) Blood , vol.99 , pp. 3885-3891
    • Levis, M.1    Abllebach, J.2    Tse, K.F.3
  • 33
    • 0003240119 scopus 로고    scopus 로고
    • Inhibition of mutant FLT3 receptors in leukemia cells by a small molecule tyrosine kinase inhibitor
    • abstract 16
    • Weisberg E, Boulton C, Louise K, et al. Inhibition of mutant FLT3 receptors in leukemia cells by a small molecule tyrosine kinase inhibitor. Proc Am Soc Clin Oncol. 2002; abstract 16.
    • (2002) Proc Am Soc Clin Oncol
    • Weisberg, E.1    Boulton, C.2    Louise, K.3
  • 34
    • 0035383789 scopus 로고    scopus 로고
    • Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase I clinical laboratory correlative trial
    • Karp JE, Lancet JE, Kaufmann SH, et al. Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase I clinical laboratory correlative trial. Blood. 2001;97:3361-3369.
    • (2001) Blood , vol.97 , pp. 3361-3369
    • Karp, J.E.1    Lancet, J.E.2    Kaufmann, S.H.3
  • 35
    • 85038471732 scopus 로고    scopus 로고
    • Phase II study of R115777, a farnesyltransferase inhibitor, in myelodysplastic syndrome
    • abstract 3520
    • Kurzrock R, Cortes J, Ryback ME, et al. Phase II study of R115777, a farnesyltransferase inhibitor, in myelodysplastic syndrome. Proc Am Soc Hematol. 2001; abstract 3520.
    • (2001) Proc Am Soc Hematol
    • Kurzrock, R.1    Cortes, J.2    Ryback, M.E.3
  • 36
    • 0029063384 scopus 로고
    • Anti-human immunodeficiency virus and anti-hepatitis-B virus activities and toxicities of the enantiomers of 2′-deoxy-3′-oxa-4′-thiocytidine and their 5-fluoro analogues in vitro
    • Mansour TS, Jin H, Wang W, et al. Anti-human immunodeficiency virus and anti-hepatitis-B virus activities and toxicities of the enantiomers of 2′-deoxy-3′-oxa-4′-thiocytidine and their 5-fluoro analogues in vitro. J Med Chem. 1995;38:1-4.
    • (1995) J Med Chem , vol.38 , pp. 1-4
    • Mansour, T.S.1    Jin, H.2    Wang, W.3
  • 37
    • 0028982940 scopus 로고
    • Anticancer activity of beta-L-dioxolane-cytidine, a novel nucleoside analogue with the unnatural L configuration
    • Grove KL, Guo X, Liu SH, et al. Anticancer activity of beta-L-dioxolane-cytidine, a novel nucleoside analogue with the unnatural L configuration. Cancer Res. 1995;55:3008-3011.
    • (1995) Cancer Res , vol.55 , pp. 3008-3011
    • Grove, K.L.1    Guo, X.2    Liu, S.H.3
  • 38
    • 0029836284 scopus 로고    scopus 로고
    • Uptake and metabolism of the new anticancer compound beta-L-(-)-dioxolanecytidine in human prostate carcinoma DU-145 cells
    • Grove KL, Cheng YC. Uptake and metabolism of the new anticancer compound beta-L-(-)-dioxolanecytidine in human prostate carcinoma DU-145 cells. Cancer Res. 1996;56:4187-4191.
    • (1996) Cancer Res , vol.56 , pp. 4187-4191
    • Grove, K.L.1    Cheng, Y.C.2
  • 39
    • 0030775136 scopus 로고    scopus 로고
    • Potent antitumor activity of a novel nucleoside analogue, BCH-4556 (beta-L-dioxolane-cytidine), in human renal cell carcinoma xenograft tumor models
    • Kadhim SA, Bowlin TL, Waud WR, et al. Potent antitumor activity of a novel nucleoside analogue, BCH-4556 (beta-L-dioxolane-cytidine), in human renal cell carcinoma xenograft tumor models. Cancer Res. 1997;57:4803-4810.
    • (1997) Cancer Res , vol.57 , pp. 4803-4810
    • Kadhim, S.A.1    Bowlin, T.L.2    Waud, W.R.3
  • 40
    • 7344255761 scopus 로고    scopus 로고
    • Activity of (-)-2′-deoxy-3′-oxacytidine (BCH-4556) against human tumor colony-forming units
    • Siu LL, Attardo G, Izbicka E, et al. Activity of (-)-2′-deoxy-3′-oxacytidine (BCH-4556) against human tumor colony-forming units. Ann Oncol. 1998;9:885-891.
    • (1998) Ann Oncol , vol.9 , pp. 885-891
    • Siu, L.L.1    Attardo, G.2    Izbicka, E.3
  • 41
    • 0035242026 scopus 로고    scopus 로고
    • Troxacitabine, a novel dioxolane nucleoside analog, has activity in patients with advanced leukemia
    • Giles FJ, Cortes JE, Baker SD, et al. Troxacitabine, a novel dioxolane nucleoside analog, has activity in patients with advanced leukemia. J Clin Oncol. 2001;19:762-771.
    • (2001) J Clin Oncol , vol.19 , pp. 762-771
    • Giles, F.J.1    Cortes, J.E.2    Baker, S.D.3
  • 42
    • 0029127419 scopus 로고
    • 2-Amino-6-methoxypurine arabinoside: An agent for T-cell malignancies
    • Lambe CU, Averett DR, Paff MT, et al. 2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies. Cancer Res. 1995;55:3352-3356.
    • (1995) Cancer Res , vol.55 , pp. 3352-3356
    • Lambe, C.U.1    Averett, D.R.2    Paff, M.T.3
  • 43
    • 0021159928 scopus 로고
    • Specific cytotoxicity of arabinosyl-guanine toward cultured T-lymphoblasts
    • Ullman B, Martin DW. Specific cytotoxicity of arabinosyl-guanine toward cultured T-lymphoblasts. J Clin Invest. 1984;74:951-955.
    • (1984) J Clin Invest , vol.74 , pp. 951-955
    • Ullman, B.1    Martin, D.W.2
  • 44
    • 0021933378 scopus 로고
    • Metabolic basis of arabinonucleoside selectivity for human leukemic T- and B-lymphoblasts
    • Verhof V, Fridland A. Metabolic basis of arabinonucleoside selectivity for human leukemic T- and B-lymphoblasts. Cancer Res. 1985;45:3646-3650.
    • (1985) Cancer Res , vol.45 , pp. 3646-3650
    • Verhof, V.1    Fridland, A.2
  • 45
    • 0033999960 scopus 로고    scopus 로고
    • Pharmacokinetics of nelarabine and 9-beta-D-arabinofuranosyl guanine in pediatric and adult patients during a phase I study of nelarabine for the treatment of refractory hematologic malignancies
    • Kisor DF, Plunkett W, Kurtzberg J, et al. Pharmacokinetics of nelarabine and 9-beta-D-arabinofuranosyl guanine in pediatric and adult patients during a phase I study of nelarabine for the treatment of refractory hematologic malignancies. J Clin Oncol. 2000;18:995-1003.
    • (2000) J Clin Oncol , vol.18 , pp. 995-1003
    • Kisor, D.F.1    Plunkett, W.2    Kurtzberg, J.3
  • 46
    • 0035871440 scopus 로고    scopus 로고
    • Evaluation of the combination of nelarabine and fludarabine in leukemias: Clinical response, pharmacokinetics, and pharmacodynamics in leukemia cells
    • Gandhi V, Plunkett W, Weller S, et al. Evaluation of the combination of nelarabine and fludarabine in leukemias: clinical response, pharmacokinetics, and pharmacodynamics in leukemia cells. J Clin Oncol. 2001;19:2142-2152.
    • (2001) J Clin Oncol , vol.19 , pp. 2142-2152
    • Gandhi, V.1    Plunkett, W.2    Weller, S.3
  • 47
    • 0030046322 scopus 로고    scopus 로고
    • Hypermethylation-associated inactivation indicates a suppressor role for p15INK4B1
    • Herman JG, Jen J, Merlo A, et al. Hypermethylation-associated inactivation indicates a suppressor role for p15INK4B1. Cancer Res. 1996;56:722-727.
    • (1996) Cancer Res , vol.56 , pp. 722-727
    • Herman, J.G.1    Jen, J.2    Merlo, A.3
  • 48
    • 0018860957 scopus 로고
    • Cellular differentiation, cytidine analogues and DNA methylation
    • Jones PA, Taylor SM. Cellular differentiation, cytidine analogues and DNA methylation. Cell. 1980;20:85-93.
    • (1980) Cell , vol.20 , pp. 85-93
    • Jones, P.A.1    Taylor, S.M.2
  • 49
    • 17444452612 scopus 로고    scopus 로고
    • Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: A multicenter phase II study in elderly patients
    • Wijermans P, Lubbert M, Verhoef G, et al. Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients. J Clin Oncol. 2000;18:956-962.
    • (2000) J Clin Oncol , vol.18 , pp. 956-962
    • Wijermans, P.1    Lubbert, M.2    Verhoef, G.3
  • 50
    • 0033233233 scopus 로고    scopus 로고
    • P15INK4b gene methylation and myelodysplastic syndromes
    • Quesnel B, Fenaux P. P15INK4b gene methylation and myelodysplastic syndromes. Leuk Lymphoma. 1999;35:437-443.
    • (1999) Leuk Lymphoma , vol.35 , pp. 437-443
    • Quesnel, B.1    Fenaux, P.2
  • 51
    • 0032459591 scopus 로고    scopus 로고
    • High-risk myelodysplastic syndromes and hypermethylation of the p15Ink4B gene
    • Uchida T, Kinoshita T, Hotta T, et al. High-risk myelodysplastic syndromes and hypermethylation of the p15Ink4B gene. Leuk Lymphoma. 1998;32:9-18.
    • (1998) Leuk Lymphoma , vol.32 , pp. 9-18
    • Uchida, T.1    Kinoshita, T.2    Hotta, T.3
  • 52
    • 0035574009 scopus 로고    scopus 로고
    • Angiogenesis, angiogenic factor expression and hematological malignancies
    • Ribatti D, Vacca A, De Falco G, et al. Angiogenesis, angiogenic factor expression and hematological malignancies. Anticancer Res. 2001;21:4333-4339.
    • (2001) Anticancer Res , vol.21 , pp. 4333-4339
    • Ribatti, D.1    Vacca, A.2    De Falco, G.3
  • 53
    • 0035674462 scopus 로고    scopus 로고
    • Angiogenesis in hematologic malignancies
    • Moehler TM, Neben K, Ho AD, et al. Angiogenesis in hematologic malignancies. Ann Hematol. 2001;80:695-705.
    • (2001) Ann Hematol , vol.80 , pp. 695-705
    • Moehler, T.M.1    Neben, K.2    Ho, A.D.3
  • 55
    • 18344413014 scopus 로고    scopus 로고
    • Clinical relevance of intracellular vascular endothelial growth factor levels in B-cell chronic lymphocytic leukemia
    • Aguayo A, O'Brien S, Keating M, et al. Clinical relevance of intracellular vascular endothelial growth factor levels in B-cell chronic lymphocytic leukemia. Blood. 2000;96:768-770.
    • (2000) Blood , vol.96 , pp. 768-770
    • Aguayo, A.1    O'Brien, S.2    Keating, M.3
  • 56
    • 0034665786 scopus 로고    scopus 로고
    • Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes
    • Aguayo A, Kantarjian H, Manshouri T, et al. Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes. Blood. 2000;96:2240-2245.
    • (2000) Blood , vol.96 , pp. 2240-2245
    • Aguayo, A.1    Kantarjian, H.2    Manshouri, T.3
  • 57
    • 0035282940 scopus 로고    scopus 로고
    • The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts
    • Smolich BD, Yuen HA, West KA, et al. The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts. Blood. 2001;97:1413-1421.
    • (2001) Blood , vol.97 , pp. 1413-1421
    • Smolich, B.D.1    Yuen, H.A.2    West, K.A.3
  • 58
    • 0034488898 scopus 로고    scopus 로고
    • The angiogenesis inhibitor SU5416 has long-lasting effects on vascular endothelial growth factor receptor phosphorylation and function
    • Mendel DB, Schreck RE, West DC, et al. The angiogenesis inhibitor SU5416 has long-lasting effects on vascular endothelial growth factor receptor phosphorylation and function. Clin Cancer Res. 2000;6:4848-4858.
    • (2000) Clin Cancer Res , vol.6 , pp. 4848-4858
    • Mendel, D.B.1    Schreck, R.E.2    West, D.C.3
  • 59
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • Fong TA, Shawver LK, Sun L, et al. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res. 1999;59:99-106.
    • (1999) Cancer Res , vol.59 , pp. 99-106
    • Fong, T.A.1    Shawver, L.K.2    Sun, L.3
  • 60
    • 0035412371 scopus 로고    scopus 로고
    • Stable remission after administration of the receptor tyrosine kinase inhibitor SU5416 in a patient with refractory acute myeloid leukemia
    • Mesters RM, Padro T, Bieker R, et al. Stable remission after administration of the receptor tyrosine kinase inhibitor SU5416 in a patient with refractory acute myeloid leukemia. Blood. 2001;98:241-243.
    • (2001) Blood , vol.98 , pp. 241-243
    • Mesters, R.M.1    Padro, T.2    Bieker, R.3
  • 61
    • 0000223203 scopus 로고    scopus 로고
    • A phase II study with SU5416 in patients with C-Kit positive AML
    • abstract 1148
    • Fiedler W, Tinnefeld H, Mende T, et al. A phase II study with SU5416 in patients with C-Kit positive AML. Proc Am Soc Clin Oncol. 2001; abstract 1148.
    • (2001) Proc Am Soc Clin Oncol
    • Fiedler, W.1    Tinnefeld, H.2    Mende, T.3
  • 62
    • 0034501632 scopus 로고    scopus 로고
    • Campath-1H monoclonal antibody therapy
    • Flynn JM, Byrd JC. Campath-1H monoclonal antibody therapy. Curr Opin Oncol. 2000;12:574-581.
    • (2000) Curr Opin Oncol , vol.12 , pp. 574-581
    • Flynn, J.M.1    Byrd, J.C.2
  • 63
    • 0030897222 scopus 로고    scopus 로고
    • Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia
    • European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia
    • Osterborg A, Dyer MJ, Bunjes D, et al. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia. J Clin Oncol. 1997;15:1567-1574.
    • (1997) J Clin Oncol , vol.15 , pp. 1567-1574
    • Osterborg, A.1    Dyer, M.J.2    Bunjes, D.3
  • 64
    • 0037085770 scopus 로고    scopus 로고
    • Campath-1H and fludarabine in combination are highly active in refractory chronic lymphocytic leukemia
    • Kennedy B, Rawstron A, Carter C, et al. Campath-1H and fludarabine in combination are highly active in refractory chronic lymphocytic leukemia. Blood. 2002;99:2245-2247.
    • (2002) Blood , vol.99 , pp. 2245-2247
    • Kennedy, B.1    Rawstron, A.2    Carter, C.3
  • 65
    • 0036139106 scopus 로고    scopus 로고
    • Campath-1H treatment of T-cell prolymphocytic leukemia in patients for whom at least one prior chemotherapy regimen has failed
    • Keating MJ, Cazin B, Coutre S, et al. Campath-1H treatment of T-cell prolymphocytic leukemia in patients for whom at least one prior chemotherapy regimen has failed. J Clin Oncol. 2002;20:205-213.
    • (2002) J Clin Oncol , vol.20 , pp. 205-213
    • Keating, M.J.1    Cazin, B.2    Coutre, S.3
  • 66
    • 0035885965 scopus 로고    scopus 로고
    • High remission rate in T-cell prolymphocytic leukemia with CAMPATH-1H
    • Dearden CE, Matutes E, Cazin B, et al. High remission rate in T-cell prolymphocytic leukemia with CAMPATH-1H. Blood. 2001;98:1721-1726.
    • (2001) Blood , vol.98 , pp. 1721-1726
    • Dearden, C.E.1    Matutes, E.2    Cazin, B.3
  • 67
    • 85038467395 scopus 로고    scopus 로고
    • Philadelphia, PA: Wyeth-Ayerst; May
    • Mylotarg [package insert]. Philadelphia, PA: Wyeth-Ayerst; May 2000.
    • (2000) Mylotarg [Package Insert]
  • 68
    • 0033151526 scopus 로고    scopus 로고
    • Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: A phase I study of an anti-CD33 calicheamicin immunoconjugate
    • Sievers EL, Appelbaum FR, Spielberger RT, et al. Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: a phase I study of an anti-CD33 calicheamicin immunoconjugate. Blood. 1999;93:3678-3684.
    • (1999) Blood , vol.93 , pp. 3678-3684
    • Sievers, E.L.1    Appelbaum, F.R.2    Spielberger, R.T.3
  • 69
    • 0034900174 scopus 로고    scopus 로고
    • Approval summary: Gemtuzumab ozogamicin in relapsed acute myeloid leukemia
    • Bross PF, Beitz J, Chen G, et al. Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia. Clin Cancer Res. 2001;7:1490-1496.
    • (2001) Clin Cancer Res , vol.7 , pp. 1490-1496
    • Bross, P.F.1    Beitz, J.2    Chen, G.3
  • 70
    • 0035397980 scopus 로고    scopus 로고
    • Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse
    • Sievers EL, Larson RA, Stadtmauer EA, et al., for the Mylotarg Study Group. Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse. J Clin Oncol. 2001;19:3244-3254.
    • (2001) J Clin Oncol , vol.19 , pp. 3244-3254
    • Sievers, E.L.1    Larson, R.A.2    Stadtmauer, E.A.3


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