The effects of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on intracellular adenosine 3′,5′-monophosphate (cAMP) levels and GH secretion in ovine and rat somatotrophs

Journal of Endocrinology

Volumn 148, Issue 2, 1996, Pages 197-205

  Wu, D ^a   Chen, C ^a   Zhang, J ^a   Bowers, C Y ^b   Clarke, I J ^a  

^a HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR;

ADENOHYPOPHYSIS; ADOLESCENT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SHEEP;

ANIMALS; CELLS, CULTURED; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; GROWTH HORMONE; GROWTH HORMONE-RELEASING HORMONE; HORMONES; IMINES; INTRACELLULAR FLUID; MALE; OLIGOPEPTIDES; PITUITARY GLAND, ANTERIOR; PROTEIN KINASE INHIBITORS; RADIOIMMUNOASSAY; RATS; RATS, WISTAR; SERMORELIN; SHEEP; SPECIES SPECIFICITY; THIONUCLEOTIDES;

EID: 0030022801     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1480197     Document Type: Article

References (20)

1. 2 stimulate growth hormone release through distinct receptor sites. Journal of Endocrinology 129 11-19
2. Bowers CY 1993 Novel GH-releasing peptides. In Molecular and Clinical Advances in Pituitary Disorders, pp 153-157 Ed S Melmed. Los Angeles: Endocrine Research and Education, Inc.
3. Bowers CY, Momany FA, Reynolds GA, Chang D, Hong A & Chang K 1980 Structure-activity relationships of a synthetic pentapeptide that specifically releases growth hormone in vitro Endocrinology 106 663-667.
4. Bowers CY, Momany FA, Reynolds GA & Hong A 1984 On the in vino and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone Endocrinology 114 1537-1545.
5. Brooker G, Hayden JF, Terasakt WL & Moylan RD 1979 RIA of cyclic AMP and cyclic GMP. Advances in Cyclic Nucleotide Research 10 1-33.
6. Chen C & Clarke IJ 1995 Effect of growth hormone-releasing peptide-2 (GHRP-2) on membrane Ca2+ permeability in cultured ovine somatotrophs. Journal of Neuroendocrinology 7 179-186.
7. Chen C, Heyward P, Zhang J, Wu D & Clarke IJ 1994a Voltage-dependent potassium currents in ovine somatotrophs and their function in growth hormone secretion. Neuroendocrinclooy 59 1-9.
8. Chen C, Vincent JD & Clarke IJ 1994b Ion channels and the signal transduction pathways in the regulation of growth hormone secretion. Trends in Endocrinology and Metabolism 5 227-233.
9. 2 on growth hormone (GH)-releasmg factor-stimulated GH release and intracellular adenosme 3′,5′-monophosphate accumulation in rat primary pituitary cell culture. Endocrinology 124 2791-2798
10. 2-induced growth hormone release from rat primary pituitary cells. Endocrinology 129 3337-3342.
11. Codd EE, Yellin T & Walker RF 1988 Binding of growth hormone-releasing hormone and enkephalin-derived growth hormone-releasing peptides to mu and delta opioid receptors in forebrain of rat. Neuropharmacology 27 1019-1025.
12. Dostmann WR, Taylor SS, Genieser HG, Jastorff B, Doskeland SO & Ogreid D 1990 Probing the cyclic nucleotide binding sites of cAMP-depencient protein kinases I and II with analogs of adenosine 3′,5′-cyclic phosphorothioates. Journal of Biological Chemistry 265 10484-10491.
13. Guellaen G, Mahu JL, Mavier P, Berthelot P & Hanoune J 1977 RMI 12330 A, an inhibitor of adenylate cyclase in rat liver. Biochimica et Biophysica Acta 484 465-475.
14. Harwood JP, Grew C & Aguilera G 1984 Action of growth hormone-releasing factor and somatostatin on adenylate cyclase and growth hormone release in rat anterior pituitary Molecular and Cellular Endocrinology 37 277-284.
15. Momany FA, Bowers CY, Reynolds GA, Hong A & Newlander K 1984 Conformational energy studies and in vitro and in vivo activity data on growth hormone-releasing peptides. Endocrinology 114 1531-1536.
16. Patel YC & Srikant CB 1986 Somatostatin mediation of adenyhypophysial secretion. Annual Review of Physiology 48 551-567.
17. ++ channel blocker MDL 12,330A in an endocrine cell. Journal of Pharmacology and Experimental Therapeutics 243 402-407.
18. Steiner AL, Parker CW & Kipris DM 1972 Radioimmunoassay for cyclic nucleotides: Preparation of antibodies and iodinated cyclic nucleotides. Journal of Biological Chemistry 247 1106-1113.
19. Wu D, Chen C, Katoh K, Zhang J & Clarke IJ 1994a The effect of GH-releasing peptide-2 (GHRP-2 or KP102) on GH secretion from primary cultured ovine pituitary cells can be abolished by a specific GH-releasing factor (GRF) receptor antagonist. Journal of Endocrinology 140 R9-R13.
20. Wu D, Chen C, Katoh K, Zhang J & Clarke IJ 1994b Effects in vitro of growth hormone-releasing factor (GRF) and growth hormone-releasing peptides (GHRPs) on growth hormone secretion from ovine pituitary cells in primary culture. Journal of Neuroendocrinology 6 185-190.