Potential role of the peroxynitrite-poly(ADP-ribose) synthetase pathway in a rat model of severe hemorrhagic shock

Shock

Volumn 9, Issue 5, 1998, Pages 341-344

  Szabó, Csaba ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRATE; OXIDIZING AGENT; PEROXYNITRIC ACID;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; BLOOD PRESSURE; CELL NUCLEUS; DEATH; DISEASE MODEL; DNA DAMAGE; ENZYMOLOGY; HEMORRHAGIC SHOCK; MALE; METABOLISM; PATHOPHYSIOLOGY; RAT; RESUSCITATION; WISTAR RAT;

ANIMALS; BLOOD PRESSURE; CELL NUCLEUS; DEATH; DISEASE MODELS, ANIMAL; DNA DAMAGE; MALE; MODELS, BIOLOGICAL; NITRATES; OXIDANTS; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, WISTAR; RESUSCITATION; SHOCK, HEMORRHAGIC;

EID: 0032059832     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-199805000-00005     Document Type: Article

References (25)

1. Cochrane CG: Mechanism of oxidant injury of cells. Mol Aspects Med 12:137-147, 1991.
2. Szabó C: DNA strand breakage and activation of poly-ADP ribosyltransferase: A cytotoxic pathway triggered by peroxynitrite. Free Rad Biol Med 21:855-869, 1996.
3. Szabó C, Zingarelli B, Salzman, AL: Role of poly-ADP ribosyltransferase activation in the nitric oxide-and peroxynitrite-induced vascular failure. Circ Res 78:1051-1063, 1996.
4. Zingarelli B, Cuzzocrea S, Zsengeller Z, Salzman AL, Szabó C: Beneficial effect of inhibition of poly-ADP ribose synthetase activity in myocardial ischemia-reperfusion injury. Cardiovasc Res 36:205-215, 1997.
5. Eliasson MJL, Sampei K, Mandir AS, et al: Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nature Med 3:1089-1095, 1997.
6. Szabó C, Salzman AL, Ischiropoulos H: Peroxynitrite-mediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia-reperfusion injury. FEBS Lett 372:229-232, 1995.
7. Salvemini D, Wang ZQ, Wyatt P, et al: Nitric oxide: A key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Br J Pharmacol 118:829-838, 1996.
8. Szabó C, Salzman AL: Inhibition of ATP-activated potassium channels improves blood pressure and survival rate in acute severe hemorrhagic shock in the rat. Shock 5:391-394, 1996.
9. Bauer PI, Kirsten E, Young LJT, et al: Modification of growth related enzymatic pathways and apparent loss of tumorigenicity of a ras-transformed bovine endothelial cell line by treatment with 5-iodo-6-amino-1,2-benzopyrone. Int J Oncol 8:239-252, 1996.
10. Szabó C, Wong HR, Bauer PI, et al: Regulation of components of the inflammatory response by 5-iodo-6-amino-1,2-benzopyrone, and inhibitor of poly(ADP-ribose) synthetase and pleiotropic modifier of cellular signal pathways. Int J Oncol 10:1093-1101, 1997.
11. Southan GJ, Zingarelli B, O'Connor M, Salzman AL, Szabó C: Spontaneous rearrangement of aminoalkylguanidines into mercaptoalkylguanidines - a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform. Br J Pharmacol 117:619-632, 1996.
12. Szabó C, Day BJ, Salzman AL: Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages, using a novel mesoporphyrin superoxide dismutase analog and peroxynitrite scavenger. FEBS Lett 381:82-86, 1996.
13. Zingarelli B, Day BJ, Crapo J, Salzman AL, Szabó C: The potential involvement of peroxynitrite in the pathogenesis of endotoxic shock. Br J Pharmacol 120:259-267, 1997.
14. Szabó C, Lim LH, Cuzzocrea S, et al: Inhibition of poly(ADP-ribose) synthetase exerts anti-inflammatory effects and inhibits neutrophil recruitment. J Exp Med 186:1041-1049, 1997.
15. Youn YK, LaLonde C, Demling R: Use of antioxidant therapy in shock and trauma. Circ Shock 35:245-249, 1991.
16. Fleckenstein AE, Smith SL, Linseman KL, Beuving LJ, Hall ED: Comparison of the efficacy of mechanistically different antioxidants in the rat hemorrhagic shock model. Circ Shock 35:223-230, 1991.
17. Lazarus HM, Warnick T, Hutto W: Influence of a protein-free diet on survival and DNA following hemorrhagic shock and ischemia. Circ Shock 13:171-181, 1984.
18. Zingarelli B, Squadrito F, Altavilla D, et al: Evidence for a role of nitric oxide in hypovolemic hemorrhagic shock. J Cardiovasc Pharmacol 19: 982-986, 1992.
19. Thiemermann C, Szabó C, Mitchell JA, Vane JR: Vascular hyporeactivity to vasoconstrictor agents and haemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide. Proc Natl Acad Sci USA, 90:267-271, 1993.
20. Vromen A, Szabó C, Southan G, Salzman AL: Protective effects of isopropyl-isothiourea, a potent inhibitor of constitutive nitric oxide synthase in rodent and porcine models of hemorrhagic shock. J Appl Physiol 81:707-715, 1996.
21. Szabó C, Virág L, Cuzzocrea S, et al: Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly (ADP-ribose) synthetase. Proc Natl Acad Sci USA. In press.
22. Liu P, Hock CE, Nagele R, Wong PY: Formation of nitric oxide, superoxide, and peroxynitrite in myocardial ischemia-reperfusion injury in rats. Am J Physiol 272:H2327-H2336, 1997.
23. Kelly E, Shah NS, Morgan NN, Watkins SC, Peitzman AB, Billiar TR: Physiologic and molecular characterization of the role of nitric oxide in hemorrhagic shock: Evidence that type II nitric oxide synthase does not regulate vascular decompensation. Shock 7:157-163, 1997.
24. Zingarelli B, Ischiropoulos H, Salzman AL, Szabó C: Improved vascular contractility and cellular energetics in the delayed phase of hemorrhagic shock by mercaptoethylguanidine, a novel inhibitor of the inducible isoform of nitric oxide synthase. Eur J Pharmacol 338:55-65, 1997.
25. Deitch EA, Bridges W, Berg R, Specian RD, Granger DN: Hemorrhagic shock-induced bacterial translocation: The role of neutrophils and hydroxyl radicals. J Trauma 30:942-951, 1990.