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Volumn 7, Issue 22, 1997, Pages 2913-2918

Rapid decomposition of peroxynitrite by manganese porphyrin-antioxidant redox couples

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; MANGANESE; PEROXYNITRITE; PORPHYRIN;

EID: 0343554032     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10109-3     Document Type: Article
Times cited : (60)

References (33)
  • 13
    • 0342370553 scopus 로고    scopus 로고
    • PCT Int. Appl. WO95/31197; Stern, M. K.; Salvemini, D., Ed., 1995
    • Stern, M. K.; Salvemini, D. PCT Int. Appl. WO95/31197; Stern, M. K.; Salvemini, D., Ed., 1995.
    • Stern, M.K.1    Salvemini, D.2
  • 19
    • 0342805455 scopus 로고    scopus 로고
    • note
    • - was synthesized following the published procedure (see ref. 16).
  • 22
    • 0342805452 scopus 로고    scopus 로고
    • Ascorbate was added to the Mn(III)TMPyP solutions immediately before the stopped-flow experiments to avoid the slow autooxidation of ascorbate catalyzed by Mn(III)TMPyP in air
    • Ascorbate was added to the Mn(III)TMPyP solutions immediately before the stopped-flow experiments to avoid the slow autooxidation of ascorbate catalyzed by Mn(III)TMPyP in air.
  • 25
    • 0342804960 scopus 로고    scopus 로고
    • note
    • -, and the extent of oxidation was evaluated as the decrease in absorbance at 340 nm of the RA chromophore. Protection of RA oxidation was attempted by adding Mn(III)TMPyP (2, 5, and 10 μM) in conjunction with ascorbate (300 μM).
  • 26
    • 0343675666 scopus 로고    scopus 로고
    • note
    • cat shown in Table 1 (R = 0.989 for glutathione; R = 0.998 for Trolox®).
  • 27
    • 0342804959 scopus 로고    scopus 로고
    • note
    • - with 1 mM 4-hydroxyphenyl acetic acid (HPA) in the present of 5 μM Mn(III)TMPyP produced 4-hydroxy-3-nitrophenyl acetic acid (nitro-HPA), which was quantitated by reverse phase HPLC analysis (Waters Delta PAK 5 μ C18 300 Å column; gradient of methanol and 5 mM pH 7.4 phosphate buffer (v/v): 10:95 at 0 min, 40:60 at 10 min). Ascorbate, Trolox® or glutathione (0.25, 0.5, 1, 2, 5 mM) was added to the reaction mixtures to prevent the nitration of HPA.
  • 30
    • 0004155427 scopus 로고
    • W. H. Freeman and Company: New York
    • Stryer, L. In Biochemistry; 4th ed.; W. H. Freeman and Company: New York, 1995, pp 731.
    • (1995) Biochemistry; 4th Ed. , pp. 731
    • Stryer, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.