SV40 early region oncoproteins and human cell transformation

Histology and Histopathology

Volumn 18, Issue 2, 2003, Pages 541-550

  Chen, W ^a,b   Hahn, William C ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Human cell transformation; Large T antigen; Small t antigen; SV40 Early Region; Tumor suppressor genes

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIN A; CYCLIN D1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; ONCOPROTEIN; PHOSPHATASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHOPROTEIN 2A; PROTEIN C FOS; PROTEIN KINASE C EPSILON; PROTEIN P27; PROTEIN P53; PROTEIN SERINE THREONINE PHOSPHATASE; PROTEIN SHC; RAS PROTEIN; RETINOBLASTOMA PROTEIN; SODIUM PROTON EXCHANGE PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TELOMERASE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; VIRUS LARGE T ANTIGEN; VIRUS PROTEIN; VIRUS SMALL T ANTIGEN;

ANTIGEN BINDING; CANCER; CANCER INHIBITION; CELL IMMORTALIZATION; CELL TRANSFORMATION; CLINICAL FEATURE; DNA TUMOR VIRUS; ENZYME ACTIVE SITE; ENZYME SUBUNIT; GENE INACTIVATION; HOST CELL; HUMAN; HUMAN CELL; MAMMAL CELL; MUTATION; NONHUMAN; ONCOGENE H RAS; PHENOTYPE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; RODENT; SIMIAN VIRUS 40; TUMOR SUPPRESSOR GENE; VIRUS ETIOLOGY;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CELL TRANSFORMATION, NEOPLASTIC; HUMANS;

DNA VIRUSES; JANUS; MAMMALIA; RODENTIA; SIMIAE; SIMIAN VIRUS; SIMIAN VIRUS 40; TUMOR VIRUS;

EID: 0037378913     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (113)

1. Bargonetti J., Reynisdottir I., Friedman P.N. and Prives C. (1992). Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53. Genes Dev. 6, 1886-1898.
2. Beachy T.M., Cole S.L., Cavender J.F. and Tevethia M.J. (2002). Regions and activities of simian virus 40 T antigen that cooperate with an activated ras oncogene in transforming primary rat embryo fibroblasts. J. Virol. 76, 3145-3157.
3. Bikel I., Montano X., Agha M.E., Brown M., McCormack M., Boltax J. and Livingston D.M. (1987). SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen. Cell 48, 321-330.
4. Bond J., Haughton M., Blaydes J., Gire V., Wynford-Thomas D. and Wyllie F. (1996). Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence. Oncogene 13, 2097-2104.
5. Brookes S., Rowe J., Ruas M., Llanos S., Clark P.A., Lomax M., James M.C., Vatcheva R., Bates S., Vousden K.H., Parry D., Gruis N., Smit N., Bergman W. and Peters G. (2002). INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence. EMBO J. 21, 2936-2945.
6. Brown M., McCormack M., Zinn K.G., Farrell M.P., Bikel I. and Livingston D.M. (1986). A recombinant murine retrovirus for simian virus 40 large T cDNA transforms mouse fibroblasts to anchorage-independent growth. J. Virol. 60, 290-293.
7. Butel J.S., Tevethia S.S., Melnick K.S., Mullane K.P., Aksoy I.A., Stubdal H., Zalvide J., Pipas J.M., Silver P.A., Roberts T.M., Schaffhausen B.S. and DeCaprio J.A. (1997). DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication. Genes Dev. 11, 1098-1110.
8. Calin G.A., Di Lasio M.G., Caprini E., Vorechovsky I., Natali P.G., Sozzi G., Croce C.M., Barbanti-Brodano G., Russo G. and Negrini M. (2000). Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of subunit A of the serine-threonine phosphatase 2A in human neoplasms. Oncogene 19, 1191-1195.
9. Carbone M., Rizzo P. and Pass H. (1997). Simian virus 40, poliovaccines and human tumours: A review of recent developments. Oncogene 15, 1877-1888.
10. Carroll R.B. and Gurney E.G. (1982). Time-dependent maturation of the simian virus 40 large T antigen-p53 complex studied by using monoclonal antibodies. J. Virol. 44, 565-573.
11. Chang L.S., Pan S., Pater M.M. and Di Mayorca G. (1985). Differential requirement for SV40 early genes in immortalization and transformation of primary rat and human embryonic cells. Virology 146, 246-261.
12. Choi Y., Lee I. and Ross S.R. (1988). Requirement of the simian virus 40 small t antigen in tumorigenesis in transgenic mice. Mol. Cell Biol. 8, 3382-3390.
13. Cohen P. (1989). The structure and regulation of protein phosphatase. Annu. Rev. Biochem. 58, 453-508.
14. Cohen P., Klumpp S. and Scheling D.L. (1989). An improved procedure for identifying and quantitating protein phosphatase in mammalian tissues. FEBS Lett. 250, 596-600.
15. Conzen S.D. and Cole C.N. (1995). The three transforming regions of SV40 T antigen are required for immortalization of primary mouse embryo fibroblasts. Oncogene 11, 2295-2302.
16. Counter C.M., Hahn W.C., Wei W., Caddle S.D., Beijersbergen R.L., Lansdorp P.M., Sedivy J.M. and Weinberg R.A. (1998). Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc. Natl. Acad. Sci. USA 95, 14723-14728.
17. Crawford L.V., Cole C.N., Smith A.E., Paucha E., Tegtmeyer P., Rundell K. and Berg P. (1978) Organization and expression of early genes of simian virus 40. Proc. Natl. Acad. Sci. USA 75, 117-121.
18. Cullen J.M., Sandgren E.P., Brinster R.L. and Maronpot R.R. (1993). Histologic characterization of hepatic carcinogenesis in transgenic mice expressing SV40 T-antigens. Vet. Pathol. 30, 111-118.
19. DeCaprio J.A., Ludlow J.W., Figge J., Shew J.Y., Huang C.M., Lee W.H., Marsilio E., Paucha E. and Livingston D.M. (1988). SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54, 275-283.
20. De Ronde A., Sol C.J., Van Strien A., Ter Schegget J. and Van Der Noordaa J. (1989). The SV40 small t antigen is essential for the morphological transformation of human fibroblasts. Virology 171, 260-263.
21. Donehower L.A., Harvey M., Slagle B.L., McArthur M.J., Montgomery C.A. Jr., Butel A. and Bradley A. (1992). Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215-221.
22. Dyson N. (1998). The regulation of E2F by pRB-family proteins. Genes Dev. 12, 2245-2262.
23. Eckner R., Ludlow J.W., Lill N.L., Oldread E., Arany Z., Modjtahedi N., DeCaprio J.A., Livingston D.M. and Morgan J.A. (1996). Association of p300 and CBP with simian virus 40 large T antigen. Mol. Cell Biol. 16, 3454-3464.
24. Fanning E. and Knippers R. (1992). Structure and function of simian virus 40 large tumor antigen. Annu. Rev. Biochem. 61, 55-85.
25. Finlay C.A., Hinds P.W. and Levine A.J. (1989). The p53 protooncogene can act as a suppressor of transformation. Cell 57, 1083-1093.
26. Friedman T., Doolittle R. and Walter G. (1978). Amino acid sequence homology between polyoma and SV40 tumor antigens deducted from nucleotide sequence. Nature 274, 291-293.
27. Frost J.A., Alberts A.S., Sontag E., Guan K., Mumby M.C. and Feramisco J.R. (1994). Simian virus 40 small t antigen cooperates with mitogen-activated kinase to stimulate AP-1 activity. Mol. Cell Biol. 14, 6244-6252.
28. Garcia A., Cereghini S. and Sontag E. (2000). Protein phosphatase 2A and phosphatidylinositol 3-kinase regulate the activity of Sp1-responsive promoters. J. Biol. Chem. 275, 9385-9389.
29. Girardi A.J., Sweet B.H., Slotnick V.B. and Hilleman M.R. (1962). Development of tumors in hamsters inoculated in the neonatal period with vacuolating virus, SV40. Proc. Soc. Exp. Biol. Med. 109, 649-660.
30. Goswami R., Turk B., Enderle K., Howe A. and Rundell K. (1992). Effect of zinc ions on the biochemical behavior of simian virus 40 small-t antigen expressed in bacteria. J. Virol. 66, 1746-1751.
31. Greenberg R.A., Allsopp R.C., Chin L., Morin G.B. and DePinho R.A. (1998). Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation. Oncogene 16, 1723-1730.
32. Hahn W.C. and Weinberg R.A. (2002). Modelling the molecular circuitry of cancer. Nat. Rev. Cancer 2, 331-341.
33. Hahn W.C., Counter C.M., Lundberger A.S., Beijersbergen R.L., Brook M.W. and Weinberg R.A. (1999). Creation of human tumor cells with defined genetic elements. Nature 400, 464-468.
34. Hahn W.C., Dessain S.K., Brooks M.W., King J.E., Elenbaas B., Sabatini D.M., DeCapiro J.A. and Weinberg R.A. (2002). Enumeration of simian virus 40 early region elements necessary for human cell transformation. Mol. Cell Biol. 22, 2111-2123.
35. Halvorsen T.L., Leibowitz G. and Levine F. (1999). Telomerase activity is sufficient to allow transformed cells to escape from crisis. Mol. Cell Biol. 19, 1864-1870.
36. Hanahan D. (1985). Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315, 115-122.
37. Hayflick L. and Moorhead P.S. (1961). The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585-621.
38. Howe A.K., Gaillard S., Bennett J.S. and Rundell K. (1998). Cell cycle progression in monkey cells expressing simian virus 40 small t antigen from adenovirus vectors. J. Virol. 72, 9637-9644.
39. Janssens V. and Goris J. (2001). Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatase implicated in cell growth and signal. Biochem. J. 353, 417-439.
40. Jasani B., Jones C.J., Radu C., Wynford-Thomas D., Navabi H., Mason M., Adams M. and Gibbs A. (2001). Simian virus 40 detection in human mesothelioma: Reliability and significance of the available evidence. Front Biosci. 6, E12-22.
41. Jiang D., Srinivasan A., Lozano G. and Robbins P.D. (1993). SV40 T antigen abrogates p53-mediated transcriptional activity. Oncogene 8, 2805-2812.
42. Kamijo T., Zindy F., Roussel M.F., Quelle D.E., Downing J.R., Ashmun R.A., Grosveld G. and Sherr C.J. (1997). Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91, 649-659.
43. Kierstead T.D. and Tevethia M.J. (1993). Association of p53 binding and immortalization of primary C57BL/6 mouse embryo fibroblasts by using simian virus 40 T-antigen mutants bearing internal overlapping deletion mutations. J. Virol. 67, 1817-1829.
44. Kipling D. and Cooke H.J. (1990). Hypervariable ultra-long telomeres in mice. Nature 347, 400-402.
45. Klein G., Powers A. and Croce C. (2002). Association of SV40 with human tumors. Oncogene 21, 1141-1149.
46. Kremmer E., Ohrst K., Kiefer J., Brewis N. and Walter G. (1997). Separation of PP2A core enzyme and holoenzyme with monoclonal antibodies against the regulatory A subunit: Abundant expression of both forms in cells. Mol. Cell Biol. 17, 1692-1701.
47. Kriegler M., Perez C.F., Hardy C. and Botchan M. (1984). Transformation mediated by the SV40 T antigens: Separation of the overlapping SV40 early genes with a retroviral vector. Cell 38, 483-491.
48. Lechward K., Awotunde O.S., Swiatek W. and Muszynska G. (2001). Protein phosphatase 2A: Variety of forms and diversity of functions. Acta Biochim. Pol. 48, 921-933.
49. Lednicky J.A. Butel J.S. (2001). Simian virus 40 regulatory region structural diversity and the association of viral archetypal regulatory regions with human brain tumors. Semin. Cancer Biol. 11, 39-47.
50. Levine A.J. (1997). p53, the cellular gatekeeper for growth and division. Cell 88, 323-331.
51. Loeken M.R. (1992). Simian virus 40 small t antigen trans activates the adenovirus E2A promoter by using mechanisms distinct from those used by adenovirus E1A. J. Virol. 66, 2551-2555.
52. Ludlow J.W., DeCaprio J.A., Huang C.M., Lee W.H., Paucha E. and Livingston D.M. (1989). SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family. Cell 56, 57-65.
53. Macera-Bloch L., Houghton J., Lenahan M., Jha K.K. and Ozer H.L. (2002). Termination of lifespan of SV40-transformed human fibroblasts in crisis is due to apoptosis. J. Cell Physiol. 190, 332-344.
54. Marsilio E., Cheng S.H., Schaffhausen B., Paucha E. and Livingston D.M. (1991) The T/t common region of simian virus 40 large T antigen contains a distinct transformation-governing sequence. J. Virol. 65, 5647-4652.
55. Martin R.G., Setlow V.P., Edwards C.A. and Vembu D. (1979). The roles of the simian virus 40 tumor antigens in transformation of Chinese hamster lung cells. Cell 17, 635-643.
56. Mateer S.C., Fedorov S.A. and Mumby M.C. (1998). Identification of structural elements involved in the interaction of simian virus 40 small tumor antigen with protein phosphatase 2A. J. Biol. Chem. 273, 35339-35346.
57. Matthews B.J., Levine A.S. and Dixon K. (1987). Deletion mutations in the small t antigen gene alter the tissue specificity of tumors induced by simian virus 40. J. Virol. 61, 1282-1285.
58. Montano X., Millikan R., Milhaven J.M., Newsom D.A., Ludlow J.W., Arthur A.K., Fanning E., Bikel I. and Livingston D.M. (1990). Simian virus 40 small tumor antigen and an amino-terminal domain of large tumor antigen share a common transforming function. Proc. Natl. Acad. Sci. USA 87, 7448-7452.
59. Mortimer E.A., Lepow M.L., Gold E., Robbins F.C., Burton G.J and Fraumeni J.F. (1981). Long-term follow-up of persons inadvertently inoculated with SV40 as neonates. New Engl. J. Med. 305, 1517-1518.
60. Mungre S., Enderle K., Turk B., Porras A., Wu Y.Q., Mumby M.C. and Rundell K. (1994). Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation. J. Virol. 68, 1675-1681.
61. Nachtigal M., Legrand A., Nagpal M.L., Nachtigal S.A. and Greenspan P. (1990). Transformation of rabbit vascular smooth muscle cells by transfection with the early region of SV40 DNA. Am. J. Pathol. 136, 297-306.
62. Newbold R.F. and Overell R.W. (1983). Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene. Nature 304, 648-651.
63. Pallas D.C., Shahrick L.K., Martin B.L., Jaspers S., Miller T.B., Brautigan D.L. and Robert T.M. (1990). Polyoma small and middle T antigen and SV40 small t antigen form stable complexes with protein phosphatase 2A. Cell 60, 167-176.
64. Peden K.W. and Pipas J.M. (1992). Simian virus 40 mutants with amino-acid substitutions near the amino terminus of large T antigen. Virus Genes 6, 107-118.
65. Pellecchia M., Szyperski T., Wall D., Georgopoulos C. and Wuthrick K. (1996). NMR structure of the J-domain and the Gly-Phe-rich region of the Escherichia coli DnaJ chaperone. J. Mol. Biol. 260, 236-250.
66. Pipas J.M. and Levine A.J. (2001). Role of T antigen interactions with p53 in tumorigenesis. Semin. Cancer Biol. 11, 23-30.
67. Porras A., Bennett J., Howe A., Tokos K., Bouck N., Henglein B., Sathyamangalam S., Thimmapaya B. and Rundell K. (1996). A novel simian virus 40 early-region domain mediates transactivation of the cyclin A promoter by small-t antigen and is required for transformation in small-t antigen-dependent assays. J. Virol. 70, 6902-6908.
68. Porras A., Gaillard S. and Rundell K. (1999). The simian virus 40 small-t and large-t antigens jointly regulate cell cycle reentry in human fibroblasts. J. Virol. 73, 3102-3107.
69. Prowse K.R. and Greider C.W. (1995). Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc. Natl. Acad. Sci. USA 92, 4818-4822.
70. Qian Y.Q., Patel D., Hartl F.U. and McColl D.J. (1996). Nuclear magnetic resonance solution structure of the human Hsp40 (HDJ-1) J-domain. J. Mol. Biol. 260, 224-235.
71. Rhim J.S., Webber M.M., Bello D., Lee M.S., Arnstein P., Chen L.S. and Jay G. (1994). Stepwise immortalization and transformation of adult human prostate epithelial cells by a combination of HPV-18 and v-Ki-ras. Proc. Natl. Acad. Sci. USA 91, 11874-11878.
72. Rubin H., Figge J., Bladon M.T., Chen L.B., Ellman M., Bikel I., Farrell M. and Livingston D.M. (1982). Role of small t antigen in the acute transforming activity of SV40. Cell 30, 469-480.
73. Ruediger R., Pham H.T. and Walter G. (2001a). Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the Aa subunit gene. Oncogene 20, 10-15.
74. Ruediger R., Pham H.T. and Walter G. (2001b). Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene. Oncogene 20, 1892-1899.
75. Rundell K. and Parakati R. (2001). The role of the SV40 ST antigen in cell growth promotion and transformation. Semin. Cancer Biol. 11, 5-13.
76. Ryan Q.C., Goonewardene I.M. and Murasko D.M. (1992). Extension of lifespan of human T lymphocytes by transfection with SV40 large T antigen. Exp. Cell Res. 199, 387-391.
77. Saenz-Robles M.T., Symonds H., Chen J. and Van Dyke T. (1994). Induction versus progression of brain tumor development: Differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen. Mol. Cell Biol. 14, 2686-2698.
78. Saenz-Robles M.T., Sullivan C.S. and Pipas J.M. (2001). Transforming functions of Simian Virus 40. Oncogene 20, 7899-7907.
79. Sashiyama H., Shino Y., Kawamata Y., Tomita Y., Ogawa N., Shimada H., Kobayashi S., Asano T., Ochiai T. and Shirasawa H. (2001). Immortalization of human esophageal keratinocytes by E6 and E7 of human papillomavirus type 16. Int. J. Oncol. 19, 97-103.
80. Shay J.W., Wright W.E. and Werbin H. (1991). Defining the molecular mechanisms of human cell immortalization. Biochim. Biophys. Acta 1072, 1-7.
81. Shenk T., Carbon J. and Berg P. (1976). Construction and analysis of viable deletion mutants of simian virus 40. J. Virol. 18, 664-671.
82. Sherr C.J. (1998). Tumor surveillance via the ARF-p53 pathway. Genes Dev. 12, 2984-2991.
83. Sherr C.J. (2001). The INK4a/ARF network in tumour suppression. Nat. Rev. Mol. Cell Biol. 2, 731-737.
84. Sleigh M.J., Topp W.C., Hanich R. and Sambrook J.F. (1978). Mutants of SV40 with an altered small t protein are reduced in their ability to transform cells. Cell 14, 79-88.
85. Smits P.H., De Ronde A., Smits H.L., Minnaar R.P., Van Der Noordaa J. and Ter Schegget J. (1992). Modulation of the human papillomavirus type 16 induced transformation and transcription by deletion of loci on the short arm of human chromosome 11 can be mimicked by SV40 small t. Virology 190, 40-44.
86. Sompayrac L.M. and Danna K.J. (1982). Isolation and characterization of simian virus 40 early region deletion mutants. J. Virol. 43, 328-331.
87. Sompayrac L.M. and Danna K.J. (1991). The amino-terminal 147 amino acids of SV40 large T antigen transform secondary rat embryo fibroblasts. Virology 181, 412-415.
88. Sontag E., Fedorov S., Kamibayashi C., Robbins D., Cobb M. and Mumby M. (1993). The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the Map kinase pathway and induces cell proliferation. Cell 75, 887-897.
89. Sontag E., Sontag J.M. and Garcia A. (1997). Protein phosphatase 2A is a critical regulator of protein kinase C zeta signal targeted by SV40 small t to promote cell growth and NF-kappaB activation. EMBO J. 16, 5662-5671.
90. Srinivasan A., Peden K.W. and Pipas J.M. (1989a). Mutants with changes within or near a hydrophobic region of simian virus 40 large tumor antigen are defective for binding cellular protein p53. Virology 168, 13-21.
91. Srinivasan A., Peden K.W. and Pipas J.M. (1989b). The large tumor antigen of simian virus 40 encodes at least two distinct transforming function. J. Virol. 63, 5459-5463.
92. Srinivasan A., McClellan A.J., Vartikar J., Marks I., Cantalupo P., Li Y., Whyte P., Rundell K., Brodsky J.L. and Pipas J.M. (1997). The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain. Mol. Cell. Biol. 17, 4761-4773.
93. Stubdal H., Zalvide J. and DeCaprio J.A. (1996). Simian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107. J. Virol. 70, 2781-2788.
94. Stubdal H., Zalvide J., Campbell K.S., Schweitzer C., Robert T.M. and DeCaprio J.A. (1997). Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol. Cell Biol. 17, 4947-4990.
95. Sugano S., Yamaguchi N. and Shimojo H. (1982). Small t protein of simian virus 40 is required for dense focus formation in a rat cell line. J. Virol. 41, 1073-1075.
96. Sullivan C.S., Cantalupo P. and Pipas J.M. (2000). The molecular chaperone activity of simian virus 40 large T antigen is required to disrupt Rb-E2F family complexes by an ATP-dependent mechanism. Mol. Cell Biol. 20, 6233-6243.
97. Syed H.A. and DeCaprio J.A. (2001). Cellular transformation by SV40 large T antigen: Interaction with host proteins. Semin. Cancer Biol. 11, 15-22.
98. Tsai J. and Douglas M.G. (1996). A conserved HPD sequence of the J-domain is necessary for YDJ1 stimulation of Hsp70 ATPase activity at a site distinct from substrate binding. J. Biol. Chem. 271, 9347-9354.
99. Turk B., Porras A., Mumby M.C. and Rundell K. (1993). Simian virus 40 small-t antigen binds two zinc ions. J. Virol. 57, 3671-3673.
100. Ugi S., Imamura T., Ricketts W. and Olefsky J.M. (2002). Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling. Mol. Cell Biol. 22, 2375-2387.
101. Wang W.B., Bikel I., Marsilio E., Newsome D. and Livingston D.M. (1994). Transrepression of RNA polymerase II promoters by the simian virus 40 small t antigen. J. Virol. 68, 6180-6187.
102. Wang S.S., Esplin E.D., Li J.L., Huang L., Gazdar A., Minna J. and Evans G.A. (1998). Alterations of the PPP2R1B gene in human lung and colon cancer. Science 282, 284-286.
103. Watanabe G., Howe A., Lee R.J., Albanese C., Shu I.W., Karnezis A.N., Zon L., Kyriakis J., Rundell K. and Pestell R.G. (1996). Induction of cyclin D1 by simian virus 40 small tumor antigen. Proc. Natl. Acad. Sci. USA 93, 12861-12886.
104. Wheat W.H., Roesler W.J. and Klemm D.J. (1994). Simian virus 40 small tumor antigen inhibits dephosphorylation of protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation. Mol. Cell Biol. 14, 5881-5890.
105. Wright W.E. and Shay J.W. (2000). Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology. Nat. Med. 6, 849-851.
106. Yang S.I., Lickteig R.L., Estes R., Rundell K., Walter G. and Mumby M.C. (1991). Control of protein phosphatase 2A by simian virus 40 small-t antigen. Mol. Cell Biol. 11, 1988-1995.
107. Yu J., Boyapati A. and Rundell K. (2001). Critical role for SV40 small-t antigen in human cell transformation. Virology 290, 192-198.
108. Zalvide J. and DeCaprio J.A. (1995). Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation. Mol. Cell Biol. 15, 5800-5810.
109. Zerrahn J., Knippschild U., Winkler T. and Deppert W. (1993). Independent expression of the transforming amino-terminal domain of SV40 large T antigen from an alternatively spliced third SV40 early mRNA. EMBO J. 12, 4739-4746.
110. Zhu J.Y., Abate M., Rice P.W. and Cole C.N. (1991). The ability of simian virus 40 large T antigen to immortalize primary mouse embryo fibroblasts cosegregates with its ability to bind to p53. J. Virol. 65, 6872-6880.
111. Zhu J., Rice P.W., Gorsch L., Abate M. and Cole C.N. (1992). Transformation of a continuous rat embryo fibroblasts cell line requires three separate domains of simian virus 40 large T antigen. J. Virol. 66, 2780-2791.
112. Zhu J., Wang H., Bishop J.M. and Blackburn E.H. (1999). Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc. Natl. Acad. Sci. USA 96, 3723-3728.
113. Zijlmans J.M., Martens U.M., Poon S.S., Raap A.K., Tanke H.J., Ward R.K. and Lansdorp P.M. (1997). Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc. Natl. Acad. Sci. USA 94, 7423-7428.