A novel simian virus 40 early-region domain mediates transactivation of the cyclin A promoter by small-t antigen and is required for transformation in small-t antigen-dependent assays

Journal of Virology

Volumn 70, Issue 10, 1996, Pages 6902-6908

  Porrás, Analía ^a   Bennett, John ^a   Howe, Alan ^a   Tokos, Karen ^a   Bouck, Noël ^a   Henglein, Berthold ^b   Sathyamangalam, Swaminathan ^a   Thimmapaya, Bayar ^a   Rundell, Kathleen ^a  

^a NORTHWESTERN UNIVERSITY MEDICAL CENTER   (United States)

^b INSTITUT CURIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; PHOSPHOPROTEIN PHOSPHATASE; VIRUS SMALL T ANTIGEN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HAMSTER; MONKEY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SIMIAN VIRUS 40; TRANSACTIVATION; VIRUS CELL TRANSFORMATION;

EID: 0029836495     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.10.6902-6908.1996     Document Type: Article

References (51)

1. Alberts, A. S., T. Deng, A. Lin, J. L. Meinkoth, A. Schonthal, M. C. Mumby, M. Karin, and J. R. Feramisco. 1993. Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements. Mol. Cell. Biol. 13:2104-2112.
2. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1990. Current protocols in molecular biology. John Wiley & Sons, New York.
3. Avantaggiati, M. L., M. Carbone, A. Graessmann, Y. Nakatani, B. Howard, and A. S. Levine. 1996. The simian virus 40 large T antigen and adenovirus E1a oncoproteins interact with distinct isoforms of the transcriptional coactivator, p300. EMBO J. 15:2236-2248.
4. Benton, B. K., O. Volpert, and N. P. Bouck. 1993. Influence of a hamster tumor suppressor gene on transformation by viral and cellular oncogenes. Carcinogenesis 14:1209-1214.
5. Bouck, N., N. Beales, T. Shenk, P. Berg, and G. di Mayorca. 1978. New region of the simian virus 40 genome required for efficient viral transformation. Proc. Natl. Acad. Sci. USA 75:2473-2477.
6. Campbell, K. S., K. R. Auger, B. A. Hemmings, T. M. Roberts, and D. C. Pallas. 1995. Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A. J. Virol. 69:3721-3728.
7. Chang, L. S., S. Pan, M. M. Pater, and G. Di Mayorca. 1985. Differential requirement for SV40 early genes in immortalization and transformation of primary rat and human embryonic cells. Virology 146:246-261.
8. Chang, L.-S., M. Pater, N. Hutchinson, and G. di Mayorca. 1984. Transformation by purified early genes of simian virus 40. Virology 133:341-353.
9. Cicala, C., M. L. Avantaggiati, A. Graessmann, K. Rundell, A. S. Levine, and M. Carbone. 1994. Simian virus 40 small-t antigen stimulates viral DNA replication in permissive monkey cells. J. Virol. 68:3138-3144.
10. De Ronde, A., C. J. A. Sol, A. van Strien, J. ter Schegget, and J. van der Noordaa. 1989. The SV40 small t antigen is essential for the morphological transformation of human fibroblasts. Virology 171:260-263.
11. Dickmanns, A., A. Zeitvogel, F. Simmersbach, R. Weber, A. K. Arthur, S. Dehde, A. G. Wildeman, and E. Fanning. 1994. The kinetics of simian virus 40-induced progression of quiescent cells into S phase depend on four independent functions of large T antigen. J. Virol. 68:5496-5508.
12. Girard, F., U. Strausfeld, A. Fernandez, and N. J. Lámb. 1991. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell 67:1169-1179.
13. Goswami, R., B. Turk, K. Enderle, A. Howe, and K. Rundell. 1992. Effect of zinc ions on the biochemical behavior of simian virus 40 small-t antigen expressed in bacteria. J. Virol. 66:1746-1751.
14. Guadagno, T. M., M. Ohtsubo, J. M. Roberts, and R. K. Assoian. 1993. A link between cyclin A expression and adhesion-dependent cell cycle progression. Science 262:1572-1575.
15. Henglein, B., X. Chenivesse, J. Wang, D. Eick, and C. Brechot. 1994. Structure and cell cycle-regulated transcription of the human cyclin A gene. Proc. Natl. Acad. Sci. USA 91:5490-5494.
16. Hiscott, J. B., and V. Defendi. 1981. Simian virus 40 gene A regulation of cellular DNA synthesis. II. In nonpermissive cells. J. Virol. 37:802-812.
17. Howe, A., and K. Rundell. Unpublished data.
18. Jog, P., B. Joshi, V. Dhamankar, M. J. Imperiale, J. Rutila, and K. Rundell. 1990. Mutational analysis of simian virus 40 small t antigen. J. Virol. 64: 2895-2900.
19. Kamibayashi, C., R. Estes, R. L. Lickleig, S. I. Yang, C. Craft, and M. C. Mumby. 1994. Comparison of heterotrimeric protein phosphatase 2A containing different B subunits. J. Biol. Chem. 269:20139-20148.
20. Kelley, W. L., and S. J. Landry. 1994. Chaperone power in a virus? Trends Biochcm. Sci. 19:2767-2768.
21. Locken, M. R. 1992. Simian virus 40 small-t antigen transactivates the adenovirus E2A promoter by using mechanisms distinct from those used by adenovirus E1A. J. Virol. 66:2551-2555.
22. Loeken, M. R. 1993. Multiple, distinct trans-activation functions are encoded by the simian virus 40 large T and small t antigens, only some of which require the 82-residue amino-terminal common domain. J. Virol. 67:7684-7689.
23. Marsilio, E., S. H. Cheng, B. Schaffhausen, E. Paucha, and D. M. Livingston. 1991. The T/t common region of simian virus 40 large T antigen contains a distinct transformation-governing sequence. J. Virol. 65:5647-5652.
24. Martin, R., V. Setlow, C. Edwards, and D. Vembu. 1979. The roles of the simian virus 40 tumor antigens in transformation of Chinese hamster lung cells. Cell 17:635-643.
25. Mungre, S., K. Enderle, B. Turk, A. Porras, Y.-Q. Wu, M. C. Mumby, and K. Rundell. 1994. Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation. J. Virol. 68:1675-1681.
26. Pallas, D. C., L. K. Shahrik, B. L. Martin, S. Jaspers, T. B. Miller, D. L. Brauligan, and T. M. Roberts. 1990. Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. Cell 60:167-176.
27. Pallas, D. C., W. Weller, S. Jaspers, T. B. Miller, W. S. Lane, and T. M. Roberts. 1992. The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton protein which is apparently substituted for by T antigens in complexes with the 36- and 63-kilodalton PP2A subunits, bears little resemblance to T antigens. J. Virol. 66:886-893.
28. Peden, K. W. C., and J. M. Pipas. 1992. Simian virus 40 mutants with amino-acid substitutions near the amino terminus of large T antigen. Virus Genes 6:107-118.
29. Phillips, B., and K. Rundell. 1988. Failure of simian virus 40 small t antigen to disorganize actin cables in nonpermissive cell lines. J. Virol. 62:768-775.
30. Pines, J., and T. Hunter. 1992. Cyclins A and B1 in the human cell cycle. Ciba Found. Symp. 170:187-196.
31. Porras, A., B. Henglein, and K. Rundell. Unpublished data.
32. Radna, R. L., Y. Caton, K. K. Jha, P. Kaplan, G. Li, F. Traganos, and H. L. Ozer. 1989. Growth of immortal simian virus 40 tsA-transformed human fibroblasts is temperature dependent. Mol. Cell. Biol. 9:3093-3096.
33. Rajan, P., V. Dhamankar, K. Rundell, and B. Thimmapaya. 1991. Simian virus 40 small-t does not transactivate RNA polymerase II promoters in virus infections. J. Virol. 65:6553-6561.
34. Rundell, K., and B. Phillips. Unpublished data.
35. Sambrook, J., E. F. Frilsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
36. Sawai, E. T., G. Rasmussen, and J. S. Butel. 1994. Construction of SV40 deletion mutants and delineation of the binding domain for heat shock protein to the amino terminus of large T-antigen. Virus Res. 31:367-378.
37. Schulze, A., K. Zerfass, D. Spitkovsky, S. Middendorp, J. Berges, K. Helin, P. Jansen-Durr, and B. Henglein. 1995. Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site. Proc. Natl. Acad. Sci. USA 92:11264-11268.
38. Smits, P. H. M., H. L. Smits, R. P. Minnaar, B. A. Hemmings, R. E. Mayer-Jaekel, R. Schuurman, J. van der Noordaa, and J. ter Schegget. 1992. The 55 kDa regulatory subunit of protein phosphatase 2A plays a role in the activation of the HPV16 long control region in human cells with a deletion in the short arm of chromosome 11. EMBO J. 12:4601-4606.
39. Sontag, E., S. Fedorov, C. Kamibayashi, D. Robbins, M. Cobb, and M. Mumby. 1993. The interaction of SV40 small t antigen with protein 'phosphatase 2A stimulates the Map kinase pathway and induces cell proliferation. Cell 75:887-897.
40. Swaminathan, S., and B. Thimmapaya. 1996. Transactivation of adenovirus E2-early promoter by E1 A and E4 6/7 in the context of viral chromosome. J. Mol. Biol. 258:736-746.
41. Symonds, H. S., S. A. McCarthy, J. Chen, J. M. Pipas, and T. Van Dyke. 1993. Use of transgenic mice reveals cell-specific transformation by a simian virus 40 T-antigen amino-terminal mutant. Mol. Cell. Biol. 13:3255-3265.
42. Thimmapaya, B., and T. Shenk. 1979. Nucleotide sequence analysis of viable deletion mutants lacking sequences of the simian virus 40 genome coding for small t antigen. J. Virol. 30:668-673.
43. Tooze, J. 1981. Molecular biology of the tumor viruses., 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
44. Turk, B., A. Porras, M. C. Mumby, and K. Rundell. 1993. Simian virus 40 small-t antigen binds two zinc ions. J. Virol. 67:3671-3673.
45. Walter, G., A. Carbone, and W. J. Welch. 1987. Medium tumor antigen of polyomavirus transformation-defective mutant NG59 is associated with 73-kilodalton heat shock protein. J. Virol. 61:405-410.
46. Walter, G., R. Ruediger, C. Slaughter, and M. C. Mumby. 1990. Association of protein phosphatase 2A with polyoma virus medium T antigen. Proc. Natl. Acad. Sci. USA 87:2521-2525.
47. Wang, W.-B., I. Bikel, E. Marsilio, D. Newsome, and D. M. Livingston. 1994. Transrepression of RNA polymerase II promoters by the simian virus 40 small t antigen. J. Virol. 68:6180-6187.
48. Yaciuk, P., M. C. Carter, J. M. Pipas, and E. Moran. 1991. Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene products. Mol. Cell. Biol. 11:2116-2124.
49. Yang, S.-I., R. L. Lickteig, R. Estes, K. Rundell, G. Walter, and M. C. Mumby. 1991. Control of protein phosphatase 2A by simian virus 40 small t antigen. Mol. Cell. Biol. 11:1988-1995.
50. Yoshizumi, M., C.-M. Hsieh, F. Zhou, J.-C. Tsai, C. Patterson, M. A. Perrella, and M.-E. Lee. 1995. The ATF site mediates downregulation of the cyclin A gene during contact inhibition in vascular endothelial cells. Mol. Cell. Biol. 15:3266-3272.
51. Zhu, J., P. W. Rice, L. Gorsch, M. Abate, and C. N. Cole. 1992. Transformation of a continuous rat embryo fibroblast cell lines requires three separate domains of simian virus 40 large T antigen. J. Virol. 66:2780-2791.