Design and synthesis of 1,5- and 2,5-substituted tetrahydrobenzazepinones as novel potent and selective integrin αVβ3 antagonists

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 7, 2003, Pages 1319-1341

  Kling, Andreas ^a   Backfisch, Gisela ^a   Delzer, Jürgen ^a   Geneste, Hervé ^a   Graef, Claudia ^b   Hornberger, Wilfried ^a   Lange, Udo E W ^b   Lauterbach, Arnulf ^b   Seitz, Werner ^b   Subkowski, Thomas ^b  

^a ABBOTT GMBH AND CO KG   (Germany)

^b BASF SE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DERIVATIVE; GUANIDINE DERIVATIVE; INTEGRIN; RECEPTOR BLOCKING AGENT; TETRAHYDROBENZAZEPINONE; UNCLASSIFIED DRUG;

ARTICLE; BINDING ASSAY; CELL ASSAY; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; ENANTIOMER; HUMAN; HUMAN CELL; IN VITRO STUDY;

EID: 0037375648     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00616-8     Document Type: Article

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