Nonpeptide αvβ3 antagonists. Part 2: Constrained glycyl amides derived from the RGD tripeptide

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 1, 2002, Pages 25-29

  Meissner, Robert S ^a   Perkins, James J ^a   Duong, Le T ^a   Hartman, George D ^a   Hoffman, William F ^a   Huff, Joel R ^a   Ihle, Nathan C ^a   Leu, Chih Tai ^a   Nagy, Rose M ^a   Naylor Olsen, Adel ^a   Rodan, Gideon A ^a   Rodan, Sevgi B ^a   Whitman, David B ^a   Wesolowski, Gregg A ^a   Duggan, Mark E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; ARGINYLGLYCYLASPARTIC ACID; INTEGRIN RECEPTOR; NAPHTHYRIDINE DERIVATIVE; PROPIONIC ACID DERIVATIVE; RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMIDES; BINDING, COMPETITIVE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; OLIGOPEPTIDES; OSTEOPOROSIS; PLATELET AGGREGATION; RECEPTORS, VITRONECTIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 18244390513     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00687-4     Document Type: Article

References (31)