Selective αvβ3-receptor blockade reduces macrophage infiltration and restenosis after balloon angioplasty in the atherosclerotic rabbit

Circulation

Volumn 103, Issue 14, 2001, Pages 1906-1911

  Bishop, Gregory G ^a,b   McPherson, John A ^a,b   Sanders, John M ^a,b   Hesselbacher, Sean E ^a,b   Feldman, Michael J ^a,b   McNamara, Coleen A ^a,b   Gimple, Lawrence W ^a,b   Powers, Eric R ^a,b   Mousa, Shaker A ^a,b   Sarembock, Ian J ^a,b,c  

^a UNIVERSITY OF VIRGINIA   (United States)

^b DUPONT COMPANY   (United States)

^c UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Angioplasty; Drugs; Inflammation; Restenosis

Indexed keywords

3 [3 [3 (4,5 DIHYDROIMIDAZOL 2 YLAMINO)PROPYLOXYLISOXAZOL 5 YL]CARBONYLAMINO] 2 (PHENYLSULFONYLAMINO)PROPIONIC ACID; ADRENERGIC RECEPTOR BLOCKING AGENT; CELL ADHESION MOLECULE; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; XT 199;

ADRENERGIC RECEPTOR BLOCKING; ANGIOCARDIOGRAPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL WALL; CELL DENSITY; CELL MIGRATION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG MECHANISM; INFLAMMATION; INTIMA; MACROPHAGE ACTIVATION; MALE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; RECEPTOR UPREGULATION; RESTENOSIS; SMOOTH MUSCLE FIBER;

EID: 0035836579     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.103.14.1906     Document Type: Article

References (35)

1. 3 integrin with a small peptide antagonist Gpen-GRGDSPCA
2. β3-Integrins rather than β1-integrins dominate integrin-matrix interactions involved in postinjury smooth muscle cell migration
3. Function and regulation of the β3 integrins in hemostasis and vascular biology
4. 3 integrin in the transmigration of monocytes
5. β3-integrins are upregulated after vascular injury and modulate thrombospondin- and thrombin-induced proliferation of cultured smooth muscle cells
6. Heparin-binding vitronectin up-regulates latent TGF-β production by bovine aortic endothelial cells
7. 3), reduces neointimal hyperplasia and total vessel area after balloon injury in hypercholesterolemic rabbits
8. 3 antagonist
9. The molecular bases of restenosis
10. Sustained activation of vascular cells and leukocytes in the rabbit aorta after balloon injury
11. 3 integrin binding affinity and specificity of SM256 in various species
12. 3 and osteopontin expression during neointima formation
13. Effectiveness of recombinant desulphatohirudin in reducing restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbits
14. Local adenovirus-mediated delivery of hirudin in a rabbit arterial injury model
15. Molecular and functional aspects of PECAM-1/CD31
16. HMG-CoA reductase inhibition by atorvastatin reduces neointimal inflammation
17. Autocrine secretion of osteopontin by vascular smooth muscle cells regulates their adhesion to collagen gels
18. Characterization of vitronectins in atherosclerotic lesions
19. Trapidil inhibits monocyte chemoattractant protein-1 and macrophage accumulation after balloon arterial injury in rabbits
20. Angiotensin-converting enzyme inhibition prevents arterial nuclear factor-kappa B activation, monocyte chemoattractant protein-1 expression, and macrophage infiltration in a rabbit model of early accelerated atherosclerosis
21. 3 integrin expression in normal and atherosclerotic artery
22. Compensatory enlargement of human atherosclerotic coronary arteries
23. Macrophage infiltration predicts restenosis after coronary intervention in patients with unstable angina
24. Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases
25. Cytokines and growth factors in atherogenesis
26. CD31/PECAM-1 is a ligand for αvβ integrin involved in adhesion of leukocytes to endothelium
27. Evidence for a role of osteopontin in macrophage infiltration in response to pathologic stimuli in vivo
28. Transforming growth factor-beta (TGF-β) is chemotactic for human monocytes and induces their expression of angiogenic activity
29. Neovascularization in atherectomy specimens from patients with unstable angina: Implications for pathogenesis of unstable angina
30. Neointimal tissue response at sites of coronary stenting in humans: Macroscopic, histological, and immunohistochemical analyses
31. Angiogenesis in human coronary atherosclerotic plaques
32. Randomised placebo-controlled and balloon-angioplasty-controlled trial to assess safety of coronary stenting with use of platelet glycoprotein-IIb/IIIa blockade
33. 3 integrins
34. Significance of quiescent smooth muscle migration in the injured rat carotid artery
35. Preparation, characterization, and evaluation of a monoclonal antibody against the rabbit platelet glycoprotein IIb/IIIa in an experimental angioplasty model