-
1
-
-
0030782039
-
-
3, see: (a) Samanen, J.; Jonak, Z.; Rieman, D.; Yue, T.-L. Curr. Pharmaceut. Design 1997, 3, 545. (b) Haubner, R.; Finsinger, D.; Kessler, H. Angew. Chem. Int. Ed. Engl. 1997, 36, 1374. (c) Horton, M. A. Int. J. Biochem. Cell Biol. 1997, 29, 721.
-
(1997)
Curr. Pharmaceut. Design
, vol.3
, pp. 545
-
-
Samanen, J.1
Jonak, Z.2
Rieman, D.3
Yue, T.-L.4
-
2
-
-
0030768536
-
-
3, see: (a) Samanen, J.; Jonak, Z.; Rieman, D.; Yue, T.-L. Curr. Pharmaceut. Design 1997, 3, 545. (b) Haubner, R.; Finsinger, D.; Kessler, H. Angew. Chem. Int. Ed. Engl. 1997, 36, 1374. (c) Horton, M. A. Int. J. Biochem. Cell Biol. 1997, 29, 721.
-
(1997)
Angew. Chem. Int. Ed. Engl.
, vol.36
, pp. 1374
-
-
Haubner, R.1
Finsinger, D.2
Kessler, H.3
-
3
-
-
0030873859
-
-
3, see: (a) Samanen, J.; Jonak, Z.; Rieman, D.; Yue, T.-L. Curr. Pharmaceut. Design 1997, 3, 545. (b) Haubner, R.; Finsinger, D.; Kessler, H. Angew. Chem. Int. Ed. Engl. 1997, 36, 1374. (c) Horton, M. A. Int. J. Biochem. Cell Biol. 1997, 29, 721.
-
(1997)
Int. J. Biochem. Cell Biol.
, vol.29
, pp. 721
-
-
Horton, M.A.1
-
4
-
-
0030841977
-
-
2. Keenan, R. M.; Miller, W. H.; Kwon, C.; Ali, F. E.; Callahan, J. F.; Calvo, R. R.; Hwang, S.-M.; Kopple, K. D.; Peishoff, C. E.; Samanen, J. M.; Wong, A. S.; Yuan, C.-K.; Huffman, W. F. J. Med. Chem. 1997, 40, 2289.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 2289
-
-
Keenan, R.M.1
Miller, W.H.2
Kwon, C.3
Ali, F.E.4
Callahan, J.F.5
Calvo, R.R.6
Hwang, S.-M.7
Kopple, K.D.8
Peishoff, C.E.9
Samanen, J.M.10
Wong, A.S.11
Yuan, C.-K.12
Huffman, W.F.13
-
5
-
-
0032542046
-
-
3. Keenan, R. M.; Miller, W. H.; Lago, M. A.; Ali, F. E.; Bondinell, W. E.; Callahan, J. F.; Calvo, R. R.; Cousins, R. D.; Hwang, S.-M.; Jakas, D. R.; Ku, T. W.; Kwon, C.; Nguyen, T. T.; Reader, V. A.; Rieman, D. S.; Ross, S. T.; Takata, D. T.; Uzinskas, I. N.; Yuan, C. C. K.; Smith, B. R. Bioorg. Med. Chem. Lett. 1998, 8, 3165.
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 3165
-
-
Keenan, R.M.1
Miller, W.H.2
Lago, M.A.3
Ali, F.E.4
Bondinell, W.E.5
Callahan, J.F.6
Calvo, R.R.7
Cousins, R.D.8
Hwang, S.-M.9
Jakas, D.R.10
Ku, T.W.11
Kwon, C.12
Nguyen, T.T.13
Reader, V.A.14
Rieman, D.S.15
Ross, S.T.16
Takata, D.T.17
Uzinskas, I.N.18
Yuan, C.C.K.19
Smith, B.R.20
more..
-
6
-
-
0032542076
-
-
4. Keenan, R. M.; Lago, M. A.; Miller, W. H.; Ali, F. E.; Cousins, R. D.; Hall, L. B.; Hwang, S.-M.; Jakas, D. R.; Kwon, C.; Louden, C.; Nguyen, T.; Ohlstein, E.; Rieman, D. S.; Ross, S. T.; Samanen, J. M.; Smith, B. R.; Stadel, J. M.; Takata, D. T.; Vickery, L.; Yuan, C. C. K.; Yue, T.-L. Bioorg. Med. Chem. Lett. 1998, 8, 3171.
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 3171
-
-
Keenan, R.M.1
Lago, M.A.2
Miller, W.H.3
Ali, F.E.4
Cousins, R.D.5
Hall, L.B.6
Hwang, S.-M.7
Jakas, D.R.8
Kwon, C.9
Louden, C.10
Nguyen, T.11
Ohlstein, E.12
Rieman, D.S.13
Ross, S.T.14
Samanen, J.M.15
Smith, B.R.16
Stadel, J.M.17
Takata, D.T.18
Vickery, L.19
Yuan, C.C.K.20
Yue, T.-L.21
more..
-
7
-
-
0028029415
-
-
5. The 2-aminopyridine ring system has previously found utility as an arginine replacement in the discovery of novel thrombin inhibitors. See: (a) Misra, R. N.; Kelly, Y. F.; Brown, B. R.; Roberts, D. G. M.; Chong, S.; Seiler, S. M. Bioorg. Med. Chem. Lett. 1994, 4, 2165. (b) Feng, D.-M.; Gardell, S. J.; Lewis, S. D.; Bock, M. G.; Chem, Z.; Freidinger, R. M.; Naylor-Olsen, A. M.; Ramjit, H. G.; Woltmann, R.; Baskin, E. P.; Lynch, J. J.; Lucas, R.; Shafer, J. A.; Dancheck, K. B.; Chen, I-W.; Mao, S.-S.; Krueger, J. A.; Hare, T. R.; Mulichack, A. M.; Vacca, J. P. J. Med. Chem. 1997, 40, 3726.
-
(1994)
Bioorg. Med. Chem. Lett.
, vol.4
, pp. 2165
-
-
Misra, R.N.1
Kelly, Y.F.2
Brown, B.R.3
Roberts, D.G.M.4
Chong, S.5
Seiler, S.M.6
-
8
-
-
9844234264
-
-
5. The 2-aminopyridine ring system has previously found utility as an arginine replacement in the discovery of novel thrombin inhibitors. See: (a) Misra, R. N.; Kelly, Y. F.; Brown, B. R.; Roberts, D. G. M.; Chong, S.; Seiler, S. M. Bioorg. Med. Chem. Lett. 1994, 4, 2165. (b) Feng, D.-M.; Gardell, S. J.; Lewis, S. D.; Bock, M. G.; Chem, Z.; Freidinger, R. M.; Naylor-Olsen, A. M.; Ramjit, H. G.; Woltmann, R.; Baskin, E. P.; Lynch, J. J.; Lucas, R.; Shafer, J. A.; Dancheck, K. B.; Chen, I-W.; Mao, S.-S.; Krueger, J. A.; Hare, T. R.; Mulichack, A. M.; Vacca, J. P. J. Med. Chem. 1997, 40, 3726.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 3726
-
-
Feng, D.-M.1
Gardell, S.J.2
Lewis, S.D.3
Bock, M.G.4
Chem, Z.5
Freidinger, R.M.6
Naylor-Olsen, A.M.7
Ramjit, H.G.8
Woltmann, R.9
Baskin, E.P.10
Lynch, J.J.11
Lucas, R.12
Shafer, J.A.13
Dancheck, K.B.14
Chen, I.-W.15
Mao, S.-S.16
Krueger, J.A.17
Hare, T.R.18
Mulichack, A.M.19
Vacca, J.P.20
more..
-
9
-
-
0002095396
-
-
Katritzky, A. R., Ed.; Academic: NY
-
6. See Albert, A. in Physical Methods in Heterocyclic Chemistry; Katritzky, A. R., Ed.; Academic: NY, 1963, Vol. 1, pp 2-103.
-
(1963)
Physical Methods in Heterocyclic Chemistry
, vol.1
, pp. 2-103
-
-
Albert, A.1
-
10
-
-
9544258252
-
-
i values represent the means of values determined in two to three separate experiments. Typical assay variability was ±10%. See Wong, A.; Hwang, S. M.; McDevitt, P.; McNulty, D.; Stadel, J. M.; Johanson, K. Mol. Pharm. 1996, 50, 529-537.
-
(1996)
Mol. Pharm.
, vol.50
, pp. 529-537
-
-
Wong, A.1
Hwang, S.M.2
McDevitt, P.3
McNulty, D.4
Stadel, J.M.5
Johanson, K.6
-
11
-
-
0028345163
-
-
i values represent the means of values determined in two to three separate experiments. Typical assay variability was ±10%. See Ali, F. E.; Bennett, D. B.; Calvo, R. R.; Elliott, J. D.; Hwang, S.-M.; Ku, T. W.; Lago, M. A.; Nichols, A. J.; Romoff, T. T.; Shah, D. H.; Vasko, J. A.; Wong, A. S.; Yellin, T. O.; Yuan, C.-K.; Samanen, J. M. J. Med. Chem. 1994, 37, 769.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 769
-
-
Ali, F.E.1
Bennett, D.B.2
Calvo, R.R.3
Elliott, J.D.4
Hwang, S.-M.5
Ku, T.W.6
Lago, M.A.7
Nichols, A.J.8
Romoff, T.T.9
Shah, D.H.10
Vasko, J.A.11
Wong, A.S.12
Yellin, T.O.13
Yuan, C.-K.14
Samanen, J.M.15
-
12
-
-
0013609761
-
-
March 29-April 2, MEDI-088
-
3 antagonists has been reported. See Wityak, J.; Pitts, W. J.; Tobin, A. E.; Estrella, M. J.; Harlow, P. P.; Corjay, M. H.; Mousa, S. A.; Wexler, R. R.; Jadhay, P. K. Book of Abstracts, 215th ACS National Meeting, March 29-April 2, 1998, MEDI-088.
-
(1998)
Book of Abstracts, 215th ACS National Meeting
-
-
Wityak, J.1
Pitts, W.J.2
Tobin, A.E.3
Estrella, M.J.4
Harlow, P.P.5
Corjay, M.H.6
Mousa, S.A.7
Wexler, R.R.8
Jadhay, P.K.9
-
14
-
-
0031031113
-
-
11. Samanen, J. M.; Lee, C.-P.; Smith, P. L.; Bondinell, W. E.; Calvo, R. R.; Jakas, D. R.; Newlander, K. A.; Parker, M.; Uzinskas, I.; Yellin, T. O.; Nichols, A. J. Advanced Drug Delivery Rev. 1996, 23, 133.
-
(1996)
Advanced Drug Delivery Rev.
, vol.23
, pp. 133
-
-
Samanen, J.M.1
Lee, C.-P.2
Smith, P.L.3
Bondinell, W.E.4
Calvo, R.R.5
Jakas, D.R.6
Newlander, K.A.7
Parker, M.8
Uzinskas, I.9
Yellin, T.O.10
Nichols, A.J.11
-
15
-
-
0001075697
-
Absorption kinetics and bioavailability
-
Swarbrick, J., Ed.; Marcel Dekker: New York
-
12. Pharmacokinetic parameters were determined using non-compartmental analysis of plasma concentration of test compound versus time data determined in two to three separate animals. Oral bioavailability was calculated from the dose-normalized i.v. and p.o. AUC values, where AUC is the area under the plasma concentration versus time curve. See: Gibaldi, M.; Perrier, D. Absorption kinetics and bioavailability. In Pharmacokinetics, 2nd ed.; Swarbrick, J., Ed.; Marcel Dekker: New York, 1982: Vol. 15, pp 145-198.
-
(1982)
Pharmacokinetics, 2nd Ed.
, vol.15
, pp. 145-198
-
-
Gibaldi, M.1
Perrier, D.2
|