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Volumn 9, Issue 13, 1999, Pages 1801-1806

Orally bioavailable nonpeptide vitronectin receptor antagonists containing 2-aminopyridine arginine mimetics

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR ANTAGONIST;

EID: 0033526909     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00282-6     Document Type: Article
Times cited : (33)

References (15)
  • 1
    • 0030782039 scopus 로고    scopus 로고
    • 3, see: (a) Samanen, J.; Jonak, Z.; Rieman, D.; Yue, T.-L. Curr. Pharmaceut. Design 1997, 3, 545. (b) Haubner, R.; Finsinger, D.; Kessler, H. Angew. Chem. Int. Ed. Engl. 1997, 36, 1374. (c) Horton, M. A. Int. J. Biochem. Cell Biol. 1997, 29, 721.
    • (1997) Curr. Pharmaceut. Design , vol.3 , pp. 545
    • Samanen, J.1    Jonak, Z.2    Rieman, D.3    Yue, T.-L.4
  • 2
    • 0030768536 scopus 로고    scopus 로고
    • 3, see: (a) Samanen, J.; Jonak, Z.; Rieman, D.; Yue, T.-L. Curr. Pharmaceut. Design 1997, 3, 545. (b) Haubner, R.; Finsinger, D.; Kessler, H. Angew. Chem. Int. Ed. Engl. 1997, 36, 1374. (c) Horton, M. A. Int. J. Biochem. Cell Biol. 1997, 29, 721.
    • (1997) Angew. Chem. Int. Ed. Engl. , vol.36 , pp. 1374
    • Haubner, R.1    Finsinger, D.2    Kessler, H.3
  • 3
    • 0030873859 scopus 로고    scopus 로고
    • 3, see: (a) Samanen, J.; Jonak, Z.; Rieman, D.; Yue, T.-L. Curr. Pharmaceut. Design 1997, 3, 545. (b) Haubner, R.; Finsinger, D.; Kessler, H. Angew. Chem. Int. Ed. Engl. 1997, 36, 1374. (c) Horton, M. A. Int. J. Biochem. Cell Biol. 1997, 29, 721.
    • (1997) Int. J. Biochem. Cell Biol. , vol.29 , pp. 721
    • Horton, M.A.1
  • 7
    • 0028029415 scopus 로고
    • 5. The 2-aminopyridine ring system has previously found utility as an arginine replacement in the discovery of novel thrombin inhibitors. See: (a) Misra, R. N.; Kelly, Y. F.; Brown, B. R.; Roberts, D. G. M.; Chong, S.; Seiler, S. M. Bioorg. Med. Chem. Lett. 1994, 4, 2165. (b) Feng, D.-M.; Gardell, S. J.; Lewis, S. D.; Bock, M. G.; Chem, Z.; Freidinger, R. M.; Naylor-Olsen, A. M.; Ramjit, H. G.; Woltmann, R.; Baskin, E. P.; Lynch, J. J.; Lucas, R.; Shafer, J. A.; Dancheck, K. B.; Chen, I-W.; Mao, S.-S.; Krueger, J. A.; Hare, T. R.; Mulichack, A. M.; Vacca, J. P. J. Med. Chem. 1997, 40, 3726.
    • (1994) Bioorg. Med. Chem. Lett. , vol.4 , pp. 2165
    • Misra, R.N.1    Kelly, Y.F.2    Brown, B.R.3    Roberts, D.G.M.4    Chong, S.5    Seiler, S.M.6
  • 15
    • 0001075697 scopus 로고
    • Absorption kinetics and bioavailability
    • Swarbrick, J., Ed.; Marcel Dekker: New York
    • 12. Pharmacokinetic parameters were determined using non-compartmental analysis of plasma concentration of test compound versus time data determined in two to three separate animals. Oral bioavailability was calculated from the dose-normalized i.v. and p.o. AUC values, where AUC is the area under the plasma concentration versus time curve. See: Gibaldi, M.; Perrier, D. Absorption kinetics and bioavailability. In Pharmacokinetics, 2nd ed.; Swarbrick, J., Ed.; Marcel Dekker: New York, 1982: Vol. 15, pp 145-198.
    • (1982) Pharmacokinetics, 2nd Ed. , vol.15 , pp. 145-198
    • Gibaldi, M.1    Perrier, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.