RPE CD14 immunohistochemical, genetic, and functional expression

Experimental Eye Research

Volumn 76, Issue 3, 2003, Pages 321-331

  Elner, Victor M ^a,b   Elner, Susan G ^a   Bian, Zong Mei ^a   Kindezelskii, Andrei L ^a   Yoshida, Ayako ^a   Petty, Howard R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

CD14; Cell signalling; Interleukin 8; Lipopolysaccharide; Resonance energy transfer; Retinal pigment epithelium

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CD14 ANTIGEN; ENZYME INHIBITOR; GAMMA INTERFERON; INOSITOL PHOSPHATE; INTERLEUKIN 8; LIGAND; LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY; PHOSPHOLIPASE C; PROTEIN KINASE C INHIBITOR; PROTEIN P13 KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EYE; GENE; GENE EXPRESSION; HRPE GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; PIGMENT EPITHELIUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

EID: 0037374190     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4835(02)00310-X     Document Type: Article

References (85)

1. Akashi S., Shimazu R., Ogata H., Nagi Y., Takeda K., Kimoto M., Miyake K. Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages. J. Immunol. 164:2000;3471-3475.
2. Anderson D.H., Johnson L.V., Hageman G.S. Vitronectin receptor expression and distribution at the photoreceptor-retinal pigment epithelial interface. J. Comp. Neurol. 360:1995;1-16.
3. Ansel J.C. The expression of functional LPS receptor proteins CD14 and toll-like receptor 4 in human corneal cells. Invest. Ophthalmol. Vis. Sci. 42:2001;2867-2877.
4. Antal-Szalmas P. Evaluation of CD14 in host defence. Eur. J. Clin. Invest. 30:2000;167-179.
5. Antal-Szalmas P., Poppelier M.J.J.G., Broekhuizen R., Verhoef J., van Strijp J.A.G., van Kessel K.P.M. Diverging pathways for lipopolysaccharide and CD14 in human monocytes. Cytometry. 41:2000;279-288.
6. Bazil V., Strominger J.L. Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes. J. Immunol. 147:1991;1567-1574.
7. Beekhuizen H., Blokland I., Corsel-van Tilburg A., Koning F., van Furth R. CD14 contributes to the adherence of human monocytes to cytokine-stimulated endothelial cells. J. Immunol. 147:1991;3761-3767.
8. Bian Z.M., Elner S.G., Strieter R.M., Glass M.B., Lukacs N.W., Kunkel S.L., Elner V.M. Glycated serum albumin induces chemokine gene expression in human retinal pigment epithelial cells. J. Leukoc. Biol. 60:1996;405-414.
9. Bian Z.M., Elner V.M., Yoshida A., Kunkel S.L., Elner S.G. Signaling pathways for glycated human serum albumin-induced IL-8 and MCP-1 secretion in human RPE cells. Invest. Ophthalmol. Vis. Sci. 42:2001;1660-1668.
10. Bian Z.M., Elner S.G., Yoshida A., Kunkel S.L., Su J., Elner V.M. Activation of p38, ERK1/2 and NIK Pathways is required for IL-1β and TNF-α-induced chemokine expression in human retinal pigment epithelial cells. Exp. Eye. Res. 73:2001;111-121.
11. Bliss C.M., Golenbock D.T., Keates S., Linevsky J.K., Kelly C.P. Helicobacter pylori lipopolysaccharide binds to CD14 and stimulates release of interleukin-8, epithelial neutrophil-activating peptide 78, and monocyte chemotactic protein 1 by human monocytes. Infect. Immun. 66:1998;5357-5363.
12. Bohuslav J., Horejsi V., Hansmann C., Stockl J., Weidle U.H., Majdic O., Bartke I., Knapp W., Stockinger H. Urokinase plasminogen activator receptor, β2-integrins, and src-kinases within a single receptor complex of human monocytes. J. Exp. Med. 181:1995;1381-1390.
13. Bufler P., Stiegler G., Schuchmann M., Hess S., Kruger C., Stelter F., Eckerskorn C., Schutt C., Engelmann H. Soluble lipopolysaccharide receptor (CD14) is released via two different mechanisms from human monocytes and CD14 transfectants. Eur. J. Immunol. 25:1995;604-610.
14. Campochiaro P.A., Jerdon J.A., Glaser B.M. The extracellular matrix of human retinal pigment epithelial cells in vivo and its synthesis in vitro. Invest. Ophthalmol. Vis. Sci. 27:1986;1615-1621.
15. Carrillo E.H., Gordon L.B.A., Goode E.B.S., Davis E.M.S., Polk H.C. Jr. Early elevation of soluble CD 14 may help identify trauma patients at high risk for infection. J. Trauma. 50:2001;810-816.
16. Dana N., Styrt B., Griffin J.D., Todd R.T., Klempner M.S., Arnaout M.A. Two functional domains in the phagocyte membrane glycoprotein Mo1 identified with monoclonal antibodies. J. Immunol. 137:1986;3259-3263.
17. Delpedro A.D., Barjavel M.J., Mamdouh Z., Faure S., Bakouche O. Signal transduction in LPS-activated aged and young monocytes. J. Interferon Cytokine Res. 18:1998;429-437.
18. Detrick B., Newsome D.A., Percopo C.M., Hooks J.J. Class II antigen expression and gamma interferon modulation of monocytes and retinal pigment epithelial cells from patients with retinitis pigmentosa. Clin. Immunol. Immunopathol. 36:1985;201-211.
19. Diamond G., Legarda D., Ryan L.K. The innate immune response of the respiratory epithelium. Immunol. Rev. 173:2000;27-38.
20. Elner V.M., Burnstine M.A., Strieter R.M., Kunkel S.L., Elner S.G. Cell-associated human retinal pigment epithelium interleukin-8 and monocyte chemotactic protein-1: immunochemical and in-situ hybridization analyses. Exp. Eye. Res. 65:1997;781-789.
21. Elner S.G., Davis H.R., Elner V.M. Acetoacetylated lipoprotein uptake by retinal pigment epithelium (RPE) cells (Abstract). Invest. Ophthalmol. Vis. Sci. 25:1984;S248.
22. Elner S.G., Elner V.M., Bian Z.M., Petty H.R., Yoshida A., Lukacs N.W., Kunkel S.L. RPE cell-monocyte binding induced chemokine production is mediated by CD14 (Abstract). Invest. Ophthalmol. Vis. Sci. 42:2001;S761. Abstract 4076.
23. Elner V.M., Elner S.G., Cornicelli J.A. Human and monkey RPE cells express native and acetylated low density lipoprotein receptors in vitro and in vitro (Abstract). Invest. Ophthalmol. Vis. Sci. 31:(suppl.):1990;370. Abstract 1820.
24. Elner V.M., Hass A., Klusken L., Yomantas S., Archer S., Stahl P. Immunofluorescent detection of surface receptors for glycoproteins on retinal pigment epithelium (RPE) cells (Abstract). Invest. Ophthalmol. Vis. Sci. 22:1982;S173.
25. Elner V.M., Nielsen J.C., Elner S.G., Franklin W.A. Immunophenothypic modulation of cultured human retinal pigment epithelial cells by gamma-interferon and phytohemagglutinin-stimulated human T-lymphocytes. Invest. Ophthalmol. Vis. Sci. 30:1989;233.
26. Elner V.M., Schaffner T., Taylor K., Glagov S. Immunophagocytic properties of retinal pigment epithelium cells. Science. 211:1981;74-76.
27. Elner S.G., Strieter R.M., Elner V.M., Rollins B.J., Del Monte M.A., Kunkel S.L. Monocyte chemotactic protein gene expression by cytokine-treated human retinal pigment epithelial cells. Lab. Invest. 64:1991;819-825.
28. Elner S.G., Elner V.M., Nielsen J.C., Torczynski E., Yu R., Franklin W.A. CD68 antigen expression by human retinal pigment epithelial cells. Exp. Eye. Res. 55:1992;21-28.
29. Ferlito M., Squadrito F., Halushka P.V., Cook J.A. Signal transduction events in Chinese hamster ovary cells expressing human CD14; effect of endotoxin desensitization. Shock. 15:2001;291-296.
30. Francis J.W., Todd R.F., Boxer L.A., Petty H.R. Histamine inhibits cell spreading and C3bi receptor clustering and diminishes hydrogen peroxide production by adherent human neutrophils. J. Cell Physiol. 147:1991;128-137.
31. Frey E.A., Miller D.S., Jahr T.G., Sundan A., Bazil V., Espevik T., Finlay B.B., Wright S.D. Soluble CD14 participates in the response of cells to lipopolysaccharide. J. Exp. Med. 176:1992;1665-1671.
32. Gregory C.D. Non-inflammatory/anti-inflammatory CD14 responses: CD14 in apoptosis. Jack R.S. Chem. Immunol. Chem. Immunol. 74:2000;122-140 Karger, Basel.
33. Grunwald U., Kruger C., Westermann J., Lukowsky A., Ehlers M., Schutt C. An enzyme-linked immunosorbent assay for the quantification of solubilised CD14 in biological fluids. J. Immunol. Methods. 155:1992;225-232.
34. Guha M., Mackman N. LPS induction of gene expression in human monocytes. Cellular Signaling. 13:2001;85-94.
35. Hailman E., Lichenstein H.S., Wurfel M.M., Miller D.S., Johnson D.A., Kelley M., Busse L.A., Zukowski M.M., Wright S.D. Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14. J. Exp. Med. 179:1994;269-277.
36. Hayashi J., Masaka T., Ishikawa I. Increased levels of soluble CD14 in sera of periodontitis patients. Infect. Immun. 67:1999;417-420.
37. Hayes K.C., Lindsey S., Stephan Z.F., Brecker D. Retinal pigment epithelium possesses both LDL and scavenger receptor activity. Invest. Ophthalmol. Vis. Sci. 30:1989;225-232.
38. Haziot A., Chen S., Ferrero E., Low M.G., Silber R., Goyert S.M. The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage. J. Immunol. 141:1988;547-552.
39. Ingalls R.R., Heine H., Lien E., Yoshimura A., Golenbock D. Bacterial sepsis and septic shock. Lipopolysaccharide recognition, CD14, and lipopolysaccharide receptors. Infect. Dis. Clin. North Am. 13:1999;341-353.
40. Jersmann H.P.A., Hii C.S.T., Hodge G.L., Ferrante A. Synthesis and surface expression of CD14 by human endothelial cells. Infect. Immun. 69:2001;479-485.
41. Jiang W., Akashi S., Miyake K., Petty H.R. Cutting edge: lipopolysaccharide induces physical proximity between CD14 and toll-like receptor 4 (TLR4) prior to nuclear translocation of NF-κB. J. Immunol. 165:2000;3541-3544.
42. Kol A., Lichtman A.H., Finberg R.W., Libby P., Kurt-Jones E.A. Cutting edge: heat shock protein (HSP) 50 activates the innate immune response: CD14 is an essential receptor for HPS60 activation of mononuclear cells. J. Immunol. 164:2000;13-17.
43. Kurt-Jones E.A., Popova L., Kwinn L., Haynes L.M., Jones L.P., Tripp R.A., Walsh E.E., Freeman M.W., Golenbock D.T., Anderson L.J., Finberg R.W. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat. Immunol. 1:2000;398-401.
44. Lauener R.P., Geha R.S., Vercelli D. Engagement of the monocyte surface antigen CD14 induces lymphocyte function-associated antigen-1/intercellular adhesion molecule-1-dependent homotypic adhesion. J. Immunol. 145:1990;1390-1394.
45. Lien E., Aukrust P., Sundan A., Muller F., Froland S.S., Espevik T. Elevated levels of serum-soluble CD14 in human immunodeficiency virus type 1 (HIV-1) infection: correlation to disease progression and clinical events. Blood. 92:1998;2084-2092.
46. Lue K.H., Lauener R.P., Winchester R.J., Geha R.S., Vercelli D. Engagement of CD14 on human monocytes terminates T cell proliferation by delivering a negative signal to T cells. J. Immunol. 147:1991;1134-1138.
47. Lynn W.A., Raetz C.R., Qureshi N., Golenbock D.T. Lipopolysaccharide-induced stimulation of CD11b/CD18 expression on neutrophils. Evidence of specific receptor-based response and inhibition by lipid A-based antagonists. J. Immunol. 147:1991;3072-3079.
48. Mathison J.C., Tobias P.S., Wolfson E., Ulevitch R.J. Plasma lipopolysaccharide (LPS)-binding protein. A key component in macrophage recognition of gram-negative LPS. J. Immunol. 149:1992;200-206.
49. McLaughlin B.J., Tarnowski B.I., Shepherd V.L. Identification of mannose 6-phosphate and mannose receptors in dystrophic and normal retinal pigment epithelium. Prog. Clin. Biol. Res. 1987;247-257.
50. Min H.W., Semnani R., Mizukami I.F., Watt K., Todd R.F. III, Liu D.Y. cDNA for Mo3, a monocyte activation antigen, encodes the human receptor for urokinase plasminogen activator. J. Immunol. 148:1992;3636-3642.
51. Monick M.M., Carter A.B., Gudmundsson G., Mallampalli R., Powers L.S., Hunninghake G.W. A phosphatidylcholine-specific phospholipase C regulates activation of p42/p44 mitogen-activated protein kinases in lipopolysaccharide-stimulated human alveolar macrophages. J. Immunol. 162:1999;3005-3012.
52. Murray P.Q., Clay C.D., Mappin C., Salmon M. Molecular analysis of resolving immune responses in uveitis. Clin. Exp. Immunol. 117:1999;455-461.
53. Nanbo W., Nishimura H., Muta T., Nagasawa S. Lipopolysaccharide stimulates HepG2 human hepatoma cells in the presence of lipopolysaccharide-binding protein via CD14. Eur. J. Biochem. 260:1999;183-191.
54. Nemoto E., Sugawara S., Tada H., Takada H., Shimauchi H., Horiuchi H. Cleavage of CD14 on human gingival fibroblasts cocultured with activated neutrophils is mediated by human leukocyte elastase resulting in down-regulation of lipopolysaccharide-induced IL-8 production. J. Immunol. 165:2000;5807-5813.
55. Nick J.A., Avdi N.J., Young S.K., Lehman L.A., McDonald P.P., Frasch S.C., Billstrom M.A., Henson P.M., Johnson G.L., Worthen G.C. Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils. J. Clin. Invest. 103:1999;851-858.
56. Nockher W.A., Bergmann L., Scherberich J.E. Increased soluble CD14 serum levels and altered CD14 expression of peripheral blood monocytes in HIV-infected patients. Clin. Exp. Immunol. 98:1994;369-374.
57. Nockher W.A., Wick M., Pfister H.-W. Cerebrospinal fluid levels of soluble CD14 in inflammatory and non-inflammatory diseases of the CNS: upregulation during bacterial infections and viral meningitis. J. Nueroimmunol. 101:1999;161-169.
58. Nockher W.A., Wigand R., Schoeppe W., Scherberich J.E. Elevated levels of soluble CD14 in serum of patients with systemic lupus erythematosus. Clin. Exp. Immunol. 96:1994;15-19.
59. Petty H.R., Kindzelskii A.L. Dissipative metabolic patterns respond during neutrophils transmembrane signaling. Proc. Natl. Acad. Sci., USA. 98:2001;3145-3149.
60. Petty H.R., Francis J.W., Todd R.F., Petrequin P., Boxer L.A. Neutrophil C3bi receptors: formation of membrane clusters during cell triggering requires intracellular granules. J. Cell. Physiol. 133:1987;235-242.
61. Pforte A., Schiessler A., Gais P., Beer B., Ehlers M., Schutt C., Ziegler-Heitbrock H.W.L. Expression of CD14 correlates with lung function impairment in pulmonary sarcoidosis. Chest. 105:1994;349-354.
62. Pugin J., Schurer-Maly C.C., Leturcq D., Moriarty A., Ulevitch R.J., Tobias P.S. Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc. Nat. Acad. Sci. USA. 90:1993;2744-2748.
63. Rao K.M.K. MAP kinase activation in macrophages. J. Leukoc. Biol. 69:2001;3-10.
64. Ryeom S.W., Silverstein R.L., Scotto A., Sparrow J.R. Binding of anionic phospholipids to retinal pigment epithelium may be mediated by the scavenger receptor CD36. J. Biol. Chem. 271:1996;20536-20539.
65. Sato T.T., Kovacich C., Boyke E.M., Haddix T.L., Weintraub A., Pohlman T.H. CD14-dependent activation of human endothelial cells by bacteroides fragilis outer membrane. J. Surg. Res. 74:1998;103-111.
66. Schlegel R.A., Krahling S., Callahan M.K., Williamson P. CD14 is a component of multiple recognition systems used by macrophages to phagocytose apoptotic lymphocytes. Cell Death Differ. 6:1999;583-592.
67. Schopf R.E., Dobmeyer J., Dobmeyer T., Morsches B. Soluble CD14 monocyte antigen in suction blister fluid and serum of patients with psoriasis. Dermatology. 186:1993;45-49.
68. Schumann R.R., Pfeil D., Lamping N., Kirschning C., Scherzinger G., Schlag P., Karawajew L., Hermann F. Lipopolysaccharide induces the rapid tyrosine phosphorylation of the mitogen-activated protein kinases erk-1 and p38 in cultured human vascular endothelial cells requiring the presence of soluble CD14. Blood. 87:1996;2805-2814.
69. Sehmi R., Wardlaw A., Cromwell O., Kay A.B. Effect of the related cytokines and interleukin-8 (IL-8) on eosinophil locomotion. FASEB J. 6:1992;A1435.
70. Shepherd V.L., Tarnowski B.I., McLaughlin B.J. Isolation and characterization of a mannose receptor from human pigment epithelium. Invest. Ophthalmol. Vis. Sci. 32:1991;1779-1784.
71. Shimazu R., Akashi S., Ogaga H., Nagai Y., Fukudome K., Miyake K., Kimoto M. MD-2, a molecule that confers lipopolysaccharide responsiveness on toll-like receptor 4. J. Exp. Med. 189:1999;1777-1782.
72. Song P.I., Abraham T.A., Park Y., Zivony A.S., Harten B., Edelhauser H.F., Ward S.L., Armstrong C.A., Ansel J.C. The expression of functional LPS receptor proteins CD14 and toll-like receptor 4 in human corneal cells. Invest. Ophthalmol. Vis. Sci. 42:2001;2867-2877.
73. Stetler F. Structure/Function relationships of CD14. Jack R.S. Chemical Immunology. Chemical Immunology. 4:2000;25-41 Karger, Basel.
74. Stetler F., Bernheiden M., Menzel R., Jack R.S., Witt S., Fan W., Pfister M., Schutt C. Mutation of amino acids 39 44 of human CD14 abrogates binding of lipopolysaccharide and Escherichia coli. Eur. J. Biochem. 243:1997;100.
75. Su G.L., Dorko K., Strom S.C., Nussler A.K., Want S.C. CD14 expression and production by human hepatocytes. J. Hepatol. 31:1999;435-442.
76. Sweet M.J., Hume D.A. Endotoxin signal transduction in macrophages. J. Leukoc. Biol. 60:1996;8-26.
77. Tapping R.I., Tobias P.S. Soluble CD14-mediated cellular responses to lipopolysaccharide. Jack R.S. Chemical Immunology. Chemical Immunology. 74:2000;108-121 Karger, Basel.
78. Todd R.F., Nadler L.M., Schlossman S.F. Antigens on human monocytes identified by monoclonal antibodies. J. Immunol. 126:1981;1435-1442.
79. Todd R.F., Roach J.A., Arnaout M.A. The modulated expression of Mo5, a human myelomonocyte plasma membrane antigen. Blood. 65:1985;964-973.
80. Uster P.S., Pagano R.E. Resonance energy transfer microscopy: observations of membrane-bound fluorescent probes in model membranes and in living cells. J. Cell Biol. 103:1986;1221-1234.
81. Wang P.-L., Sato K., Oido M., Fujii T., Kowashi Y., Shinohara M., Ohura K., Tani H., Kuboki Y. Involvement of CD14 on human gingival fibroblasts in Porphyromonas gingivalis lipopolysaccharide-mediated interleukin-5 secretion. Arch. Oral Biol. 43:1998;687-694.
82. Wessendorf M.W., Appel N.M., Elde R. Simultaneous observation of fluorescent retrogradely labeled neurons and the immunofluorescently labeled fibers apposing them using fluoro-gold and antisera labeled with the blue fluorochrome7-amino-4-methylcoumarin-3-acetic acid (AMCA). Neurosci. Lett. 82:1987;121-126.
83. Wright S.D., Ramos R.A., Tobias P.S., Ulevitch R.J., Mathison J.C. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science. 249:1990;1431-1433.
84. Zhou M.J., Todd R.F., Petty H.R. Detection of transmembrane linkages between immunoglobulin or complement receptors and the neutrophil's cortical microfilaments by resonance energy transfer microscopy. J. Mol. Biol. 218:1991;263-268.
85. Zhou M.J., Todd R.F., van de Winkel J.G., Petty R.R. Cocapping of the leukoadhesion molecules complement receptor type 3 and lymphocyte function-associated antigen-1 with Fcγ receptor III on human neutrophils: possible role of lectin-like interactions. J. Immunol. 150:1993;3030-3041.