CD14 is a component of multiple recognition systems used by macrophages to phagocytose apoptotic lymphocytes

Cell Death and Differentiation

Volumn 6, Issue 6, 1999, Pages 583-592

  Schlegel, Robert A ^a   Krahling, Stephen ^a   Callahan, Melissa K ^a   Williamson, Patrick ^b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b AMHERST COLLEGE   (United States)

Author keywords

Apoptosis; Monocytes macrophages; Phagocytosis; T lymphocytes

Indexed keywords

CD14 ANTIGEN; GLYCOSYLPHOSPHATIDYLINOSITOL; PHOSPHOLIPASE C;

APOPTOSIS; ARTICLE; ERYTHROCYTE; LYMPHOCYTE; MACROPHAGE; MACROPHAGE ACTIVATION; PHAGOCYTOSIS; PRIORITY JOURNAL; THYMOCYTE;

EID: 0032968923     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400529     Document Type: Article

References (20)

1. Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton JL and Henson PM (1992) Exposure of phosphatidylserine on the surface of apoptolic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol. 148: 2207-2216
2. Fadok VA, Savill JS, Haslett C, Bratton DL, Doherty DE, Campbell PA and Henson PM (1992) Different populations of macrophages use either the vitronectin receptor or the phophatidylserine receptor to recognize and remove apoptotic cells. J. Immunol. 149: 4029-4035
3. Fadok VA, Laszlo DJ, Noble PW, Weinstein L, Riches DWH and Henson PM (1993) Particle digestibility is required for induction of phosphatidylserine recognition mechanism used by murine macrophages to phagocytose apoptotic cells. J. Immunol. 151: 4274-4284
4. Pradhan D, Krahling S, Williamson P and Schlegel RA (1997) Multiple systems for recognition of apoptotic lymphocytes by macrophages. Mol. Biol. Cell 8: 767-778
5. Williamson P and Schlegel RA (1994) Back and forth: the regulation and function of transbilayer phospholipid movement in eukaryotic cells (Review). Mol. Memb. Biol. 11: 199-216
6. Tang X, Halleck MS, Schlegel RA and Williamson P (1996) A subfamily of P-type ATPases with aminophospholipid transporting activity. Science 272: 1495-1497
7. Verhoven B, Schlegel RA and Williamson P (1995) Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes. J. Exp. Med. 82: 1597-1601
8. Krahling S, Callahan MK, Williamson P and Schlegel RA (1999) Exposure of phosphatidylserine is a general feature in the phagocytosis of apoptotic lymphocytes by macrophages. Cell Death Differ. 6: 183-189
9. Ugolini V, Nunez G, Smith RG, Stastny P and Capra JD (1980) Initial characterization of monoclonal antibodies against human monocytes. Proc. Natl. Acad. Sci. USA 77: 6764-6768
10. Flora PK and Gregory CD (1994) Recognition of apoptotic cells by human macrophages: inhibition by a monocyte/macrophage-specific monoclonal antibody. Eur. J. Immunol. 24: 2625-2632
11. Devitt A, Raykundalia C. Moffatt OD, Capra JD, Simmons DL and Gregory CD (1998) Human CD14 mediates recognition and phagocytosis of cells undergoing apoptosis. Nature 392: 505-507
12. Ulevitch RJ and Tobias PS (1995) Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin (Review). Annu. Rev. Immunol. 13: 437-457
13. Pradhan D, Williamson P and Schlegel RA (1994) Phosphatidylserine vesicles inhibit phagocytosis of erythrocytes with a symmetric transbilayer distribution of phospholipids. Mol. Memb. Biol. 11: 181-188
14. McEvoy L, Williamson P and Schlegel RA (1986) Membrane phospholipid asymmetry as a determinant of erythrocyte recognition by macrophages. Proc. Natl. Acad. Sci. USA 83: 3311-3315
15. Haziot A, Chen S, Ferrera E, Low MG, Silber R and Goyert SM (1988) The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage. J. Immunol. 141: 547-552
16. Hara-Kuge S, Amano F, Nishijima M and Akamatsu Y (1990) Isolation of a lipopolysaccharide (LPS)-resistant mutant with defective LPS binding, of a cultured macrophage-like cell. J. Biol. Chem. 265: 6606-6610
17. Nishijima M, Hara-Kuge S, Takasuka N, Akagawa K, Setouchi M, Matsuura K, Yamamoto S and Akamatsu Y (1994) Identification of a biochemical lesion, and characteristic response to LPS of a cultured macrophage-like cell mutant with defective LPS-binding. J. Biochem. 116: 1082-1087
18. Schlegel RA, Reed J, McEvoy L, Algarin L and Williamson P (1987) Phospholipid asymmetry of loaded red cells. Meths. Enzymol. 149: 281-293
19. Fadok VA, Warner ML, Bratton DL and Henson PM (1998) CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3). J. Immunol. 161: 6250-6257
20. Wang P, Kitchen RL and Munford RS (1998) Phosphatidylinositides bind to plasma membrane CD14 and can prevent monocyte activation by bacterial lipopolysaccharide. J. Biol. Chem. 273: 24309-24313