Cleavage of CD14 on human gingival fibroblasts cocultured with activated neutrophils is mediated by human leukocyte elastase resulting in down-regulation of lipopolysaccharide-induced IL-8 production

Journal of Immunology

Volumn 165, Issue 10, 2000, Pages 5807-5813

  Nemoto, E ^a   Sugawara, S ^a   Tada, H ^a   Takada, H ^a   Shimauchi, H ^a   Horiuchi, H ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD59 ANTIGEN; DIPEPTIDYL PEPTIDASE IV; INTERLEUKIN 1ALPHA; INTERLEUKIN 8; LEUKOCYTE ELASTASE; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEINASE; PROTEINASE INHIBITOR;

ADOLESCENT; ADULT; ARTICLE; CHILD; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME PURIFICATION; FIBROBLAST; FLOW CYTOMETRY; GINGIVA; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE ACTIVATION; NEGATIVE FEEDBACK; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN DEGRADATION;

EID: 0034669918     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.10.5807     Document Type: Article

References (51)

1. Mechanisms of disease: Tissue destruction by neutrophils
2. A relationship between proteinase activity and clinical parameters in the treatment of periodontal disease
3. Increased release of elastase from in vitro activated peripheral neurophils in patients with adult periodontitis
4. Elastase and α-1-proteinase inhibitor in gingival crevicular fluid and gingival tissue in adult and juvenile periodontitis
5. Current concepts: Immunology: Neutrophils in human diseases
6. Tissue injury in inflammation: Oxidants, proteinases, and cationic proteins
7. Fibroblasts as sentinel cells: Synthesis of chemokines and regulation of inflammation
8. Heterogeneous expression and release of CD14 by human gingival fibroblasts: Characterization and CD14-mediated interleukin-8 secretion in response to lipopolysaccharide
9. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
10. CD14 is a pattern recognition receptor
11. CD14 and innate recognition of bacteria
12. Novel trends in neutrophil structure, function and development
13. The production of cytokines by polymorphonuclear neutrophils
14. Adhesive interactions between fibroblasts and polymorphonuclear neutrophils in vitro
15. Fibroblasts increase adhesion to neutrophils after stimulation with phorbol ester and cytokines
16. Tumor necrosis factor-α but not interleukin-1 induces polymorphonuclear leukocyte migration through fibroblast layers by a fibroblast-dependent mechanism
17. Cellular activation through the ligation of intercellular adhesion molecule-1
18. Circulating promyelocytes and low levels of CD16 expression on polymorphonuclear leukocytes accompany early-onset periodontitis
19. Increase of CD26/dipeptidyl peptidase IV expression on human gingival fibroblasts upon stimulation with cytokines and bacterial components
20. Cell surface-bound elastase and cathepsin G on human neutrophils: A novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases
21. IL-1β primes IL-8-activated human neutrophils for elastase release, phospholipase D activity, and calcium flux
22. Kinetic mechanism of the inhibition of cathepsin G by α1-antichymotrypsin and α1-proteinase inhibitor
23. In vitro killing of oral Capnocytophaga by granule fractions of human neutrophils is associated with cathepsin G activity
24. Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase: Structural and functional properties
25. The two soluble forms of the lipopolysaccharide receptor, CD14: Characterization and release by normal human monocytes
26. Metalloprotease and serine protease are involved in cleavage of CD43, CD44, and CD16 from stimulated human granulocytes: Induction of cleavage of L-selectin via CD16
27. Release of glycosylphosphatidylinositol-anchored ADP-ribosyltransferase from cytotoxic T cells upon activation
28. Mitogen-activated protein kinase involves neutrophil elastase-induced morphological changes in human bronchial epithelial cells
29. Neutrophil elastase enhances macrophage production of chemokines in receptor-mediated reaction
30. Cytokines regulate membrane-bound leukocyte elastase on neutrophils: A novel mechanism for effector activity
31. Quantum proteolysis resulting from release of single granules by human neutrophils: A novel, nonoxidative mechanism of extracellular proteolytic activity
32. Pericellular proteolysis by neutrophils in the presence of proteinase inhibitors: Effects of substrate opsonization
33. Human neutrophil elastase abolishes interleukin-8 chemotactic activity
34. Soluble intercellular adhesion molecule-1 provokes polymorphonuclear leukocyte elastase release by CD18
35. Soluble ICAM-1 (sICAM-1) provokes PMN elastase release
36. Proteolytic cleavage of ICAM-1 by human neutrophil elastase
37. Mice lacking neutrophil elastase reveal impaired host defense against Gram negative bacterial sepsis
38. Elastase: Catalytic and biological properties
39. Neutrophil proteinases and matrix degradation: The cell biology of pericellular proteolysis
40. Elastase release of basic fibroblast growth factor in pulmonary fibroblast cultures results in down-regulation of elastin gene transcription: A role for basic fibroblast growth factor in regulating lung repair
41. Elastase-mediated release of heparan sulfate proteoglycans from pulmonary fibroblast cultures: A mechanism for basic fibroblast growth factor (bFGF) release and attenuation of bfgf binding following elastase-induced injury
42. Human mast cell chymase and leukocyte elastase release latent transforming growth factor-β 1 from the extracellular matrix of cultured human epithelial and endothelial cells
43. Cleavage of lymphocyte surface antigens CD2, CD4, and CD8 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis
44. Specific sensitivity of CD43 to neutrophil elastase
45. Proteolysis of monocyte CD14 by human leukocyte elastase inhibits lipopolysaccharide-mediated cell activation
46. Soluble CD14 mediates lipopolysaccharide-induced intercellular adhesion molecule 1 expression in cultured human gingival fibroblasts
47. Enhancement of cathepsin G-induced platelet activation by leukocyte elastase: Consequence for the neutrophil-mediated platelet activation
48. Neutrophils and host defense
49. Early accumulation of neutrophils in acute inflammatory lesions
50. Kreshover lecture: Molecular factors influencing neutrophil defects in periodontal disease
51. Peripheral PMN cells in juvenile periodontitis: Increased release of elastase and of oxygen radicals after stimulation with opsonized bacteria