Lipopolysaccharide induces the rapid tyrosine phosphorylation of the mitogen-activated protein kinases erk-1 and p38 in cultured human vascular endothelial cells requiring the presence of soluble CD14

Blood

Volumn 87, Issue 7, 1996, Pages 2805-2814

  Schumann, R R ^a   Pfeil, D ^b   Lamping, N ^b   Kirschning, C ^b   Scherzinger, G ^b   Schlag, P ^b   Karawajew, L ^b   Herrmann, F ^b  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CD14 ANTIGEN; GENISTEIN; LIPID A; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; PHOSPHORYL LIPID A; PHOSPHOTYROSINE; PROTEIN TYROSINE KINASE INHIBITOR; TYRPHOSTIN;

ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; VASCULAR ENDOTHELIUM;

EID: 0029881378     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.7.2805.bloodjournal8772805     Document Type: Article

References (50)

1. Raetz CRH, Ulevitch RJ, Wright SD, Sibley CH, Ding A, Nathan CF: Gram-negative endotoxin: An extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J 5:2652, 1991
2. Rietschel ET, Brade H: Bacterial Endotoxins. Sci Am 267:54, 1992
3. Nathan CF: Secretory products of macrophages. J Clin Invest 97:319, 1987
4. Schumann RR, Herrmann F: The macrophage, a tissue specific defense cell: Origin, tissue distribution and secretorx response. Focus on growth factors 3:1, 1994
5. Pugin J, Schurer MC, Leturcq D, Moriarty A, Ulevitch RJ, Tobias PS: Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc Natl Acad Sci USA 90:2744, 1993
6. Golenbock DT, Liu Y, Millham FH, Freeman MW, Zoeller RA: Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin. J Biol Chem 268:22055, 1993
7. Faruqi R, Delamotte C, Dicorleto PE: Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells. J Clin Invest 94:592, 1994
8. Bevilacqua MP, Pober JS, Wheeler ME, Cotran RS, Gimbrone MA Jr: Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes and related leukocyte cell lines. J Clin Invest 76:2003, 1985
9. Bevilacqua MP, Nelson RM, Mannori G, Cecconi O: Endothelial-leukocyte adhesion molecules in human disease. Annu Rev Med 45:361, 1994
10. Pettersen KS, Wiiger MT, Narahara N, Andoh K, Gaudernack G, Prydz H: Induction of tissue factor synthesis in human umbilical vein endothelial cells involves protein kinase C. Thromb Haemost 67:473, 1992
11. Schumann RR, van der Bosch J, Rüller S, Ernst M, Schlaak M: Monocyte long-term cultivation on microvascular endothelial cell monolayers: morphologic and phenotypic characterization and comparison with monocytes cultured on tissue culture plastic. Blood 73:818, 1989
12. Vane JR, Anggard EE, Botting RM: Regulatory functions of the vascular endothelium. N Engl J Med 323:27, 1990
13. Schumann RR, Rietschel ET, Loppnow H: The role of CD14 and Lipopoly-saccharide binding protein in the activation of different cell types by endotoxin. Med Microbiol Immunol 183:279, 1994
14. Tobias P, Soldau K, Ulevitch RJ: Isolation of a Lipopolysaccharide-Binding Acute Phase Reactant from rabbit serum. J Exp Med 164:777, 1986
15. Schumann RR, Leong SR, Flaggs GW, Gray PW, Wright SD, Mathison JC, Tobias PS, Ulevitch RJ: Structure and function of lipopolysaccharide binding protein. Science 249:1429, 1990
16. Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC: CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249:1431, 1990
17. Schutt C, Schumann RR: The endotoxin receptor CD14. Immun Infekt 21:36, 1993
18. Schumann RR: Function of lipopolysaccharide (LPS)-binding protein (LBP) and CD14, the receptor for LPS/LBP complexes: A short review. Res Immunol 143:11, 1992
19. Ulevitch RJ, Tobias PS: Recognition of endotoxin by cells leading to transmembrane signaling. Curr Opin Immunol 6:125, 1994
20. Weinstein SL, Gold MR, DeFranco AL: Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages. Proc Natl Acad Sci USA 88:4148, 1991
21. Han J, Lee JD, Bibbs L, Ulevitch RJ: A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265:808, 1994
22. Lee J, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, McNulty D, Blumenthal MJ, Heys JR, Landvatter SW, Strickler JE, McLaughlin MM, Siemens IR, Fisher SM, Livi GP, White JR, Adams JL, Young PR: A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372:739, 1994
23. Frey EA, Miller DS, Jahr TG, Sundan A, Bazil V, Espevik T, Finlay BB, Wright SD: Soluble CD14 participates in the response of cells to lipopolysaccharide. J Exp Med 176:1665, 1992
24. Jaffe EA, Nachman RL, Becker CG, Minick CR: Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 52:2745, 1973
25. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248, 1976
26. Sambrock J, Fritsch EF, Maniatis T: Molecular Cloning, New York, NY, Cold Spring Harbor Laboratory, 1989
27. Liu J, Mathias S, Yang Z, Kolesnick RN: Renaturation and tumor necrosis factor-α stimulation of a 97-kDa ceramide-activated protein kinase. J Biol Chem 269:3047, 1994
28. Astiz ME, Rackow EC, Kim YB, Weil MH: Hemodynamic effects of monophosphoryl lipid A compared to endotoxin. Circ Shock 27:193, 1989
29. Brandtzaeg P, Kierulf P, Gaustad P, Skulberg A, Bruun JN, Halvorsen S, Sorensen E: Plasma endotoxin as a preedictor of multiple organ failure and death in systemic meningococcal disease. J Inf Dis 159:195, 1989
30. Danner RL, Elin RJ, Hosseini JM, Wesley RA, Reilly JM, Parillo JE: Endotoxemia in human septic shock. Chest 99:169, 1991
31. Lee C-H, Reis Y, Jong J, Y-H K: Lipopolysaccharide-induced differential cell surface expression of intercellular adhesion molecule-1 in cultured human umbilical cord vein endothelial cells. Shock 3:96, 1995
32. Han J, Lee J-D, Tobias PS, Ulevitch RJ: Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14. J Biol Chem 268:25009, 1993
33. Stefanova I, Corcoran ML, Horak EM, Wahl LM, Bolen JB, Horak ID: Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn. J Biol Chem 268:20725, 1993
34. Liu MK, Herreravelit P, Brownsey RW, Reiner NE: CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide. J Immunol 153:2642, 1994
35. Weinstein SL, Sanghera JS, Lemke K, DeFranco AL, Pelech SL: Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages. J Biol Chem 267:14955, 1992
36. Dong Z, Qi X, Fidler I: Tyrosine phosphorylation of mitogen-activated protein kinases is necessary for activation of murine macrophages by natural and synthetic bacterial products. J Exp Med 177:1071, 1993
37. Haziot A, Rong GW, Silver J, Goyert SM: Recombinant soluble CD14 mediates the activation of endothelial cells by lipopolysaccharide. J Immunol 151:1500, 1993
38. Jaffe EA: Physiologic functions of normal endothelial cells. Ann NY Acad Sci 454:279, 1985
39. Li VW, Folkerth RD, Watanabe H, Yu C, Rupnick M, Barnes P, Scott RM, Black PM, Sallan SE, Folkman J: Microvessel count and cerebrospinal fluid basic fibroblast growth factor in children with brain tumours. Lancet 344:82, 1994
40. Osborn L: Leukocyte adhesion to endothelium in inflammation. Cell 62:3, 1990
41. Springer TA: Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell 76:301, 1994
42. Liotta LA, Steeg PS, Stetler SW: Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation. Cell 64:327, 1991
43. Ezekowitz RA, Mulliken JB, Folkman J: Interferon alfa-2a therapy for life-threatening hemangiomas of infancy. N Engl J Med 326:1456, 1992
44. Boeynaems J-M, Pirotton S: Regulation of the vascular endothelium: Signals and transduction mechanisms. Austin, TX, R. G. Landes Co, 1994
45. Schneeberger PM, Vanlangevelde P, Vankessel K, Vandenbrouckegrauls CMJE, Verhoef J: Lipopolysaccharide induces hyperadhesion of endothelial cells for neutrophils leading to damage. Shock 2:296, 1994
46. Lane TA, Lamkin GE, Wancewicz EV: Protein kinase C inhibitors block the enhanced expression of intercellular adhesion molecule-1 on endothelial cells activated by interleukin-1, lipopolysaccharide and tumor necrosis factor. Biochem Biophys Res Commun 172:1273, 1990
47. Sung CP, Arleth AJ, Nambi P: Evidence for involvement of protein kinase C in expression of intracellular adhesion molecule-1 (ICAM-1) by human vascular endothelial cells. Pharmacology 48:143, 1994
48. Yang ZG, Bochsler PN, Carroll RC, Carter CD, Khemlani LS, Breider MA: Signal transduction pathways of bacterial lipopolysaccharide-stimulated bovine vascular endothelial cells. Inflammation 18:221, 1994
49. Novogrodsky A, Vanichkin A, Patya M, Gazit A, Osherov N, Levitzki A: Prevention of Lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science 264:1319, 1994
50. Natanson C, Hoffman WD, Suffredini AF, Eichacker PQ, Danner RL: Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis. Ann Intern Med 120:771, 1994