Cytokines induce HIF-1 DNA binding and the expression of HIF-1-dependent genes in cultured rat enterocytes

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 284, Issue 3 47-3, 2003, Pages

  Scharte, Marion ^a,b   Han, Xiaonan ^b   Bertges, Daniel J ^b   Fink, Mitchell P ^b,c   Delude, Russell L ^b  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c 616 Scaife Hall ^*  (United States)

Author keywords

Aldolase A; Deoxyribonucleic acid; Enolase 1; Epithelium; Glycolysis; Hypoxia inducible factor 1; Intestinal; Nitric oxide; Vascular endothelial growth factor

Indexed keywords

CYTOKINE; ENOLASE; FRUCTOSE BISPHOSPHATE ALDOLASE; GAMMA INTERFERON; HYPOXIA INDUCIBLE FACTOR 1; INTERLEUKIN 1BETA; LYSINE DERIVATIVE; MESSENGER RNA; NITRIC OXIDE; TUMOR NECROSIS FACTOR; VASCULOTROPIN;

ADAPTATION; ANIMAL CELL; ARTICLE; CELL HYPOXIA; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION REGULATION; GLYCOLYSIS; INTESTINE CELL; INTESTINE EPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; RAT; REGULATORY MECHANISM; STEADY STATE;

EID: 0037372369     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00076.2002     Document Type: Article

References (52)

1. Akman HO, Zhang H, Siddiqui MA, Solomon W, Smith EL, and Batuman OA. Response to hypoxia involves transforming growth factor-beta2 and Smad proteins in human endothelial cells. Blood 98: 3324-3331, 2001.
2. Albina JE and Mastrofancesco B. Modulation of glucose metabolism in macrophages by products of nitric oxide synthase. Am J Physiol Cell Physiol 264: C1594-C1599, 1993.
3. Albina JE, Mastrofrancesco B, Vessella JA, Louis CA, Henry WL Jr, and Reichner JS. HIF-1 expression in healing wounds: HIF-1α induction in primary inflammatory cells by TNF-α. Am J Physiol Cell Physiol 281: C1971-C1977, 2001.
4. Bagby GJ, Lang CH, Giaimo ME, and Spitzer JJ. Increased glucose metabolism by epitrochlearis muscle removed from endotoxin-treated rats. Circ Shock 20: 171-179, 1986.
5. Ben-Av P, Crofford LJ, Wilder RL, and Hla T. Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1: a potential mechanism for inflammatory angiogenesis. FEBS Lett 372: 83-87, 1995.
6. Benigni F, Atsumi T, Calandra T, Metz C, Echtenacher B, Peng T, and Bucala R. The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle. J Clin Invest 106: 1291-1300, 2000.
7. Bertges DJ, Fink MP, and Delude RL. Hypoxia inducible factor-1 DNA binding is induced by cytokines. Surg Forum 50: 273-275, 1999.
8. Caniggia I, Mostachi H, Winter J, Gassmann M, Lye SJ, Kuliszewski M, and Post M. Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). J Clin Invest 105: 577-587, 2000.
9. Chavez A, Menconi MJ, Hodin RA, and Fink MP. Cytokine-induced epithelial hyperpermeability: role of nitric oxide. Crit Care Med 27: 2246-2251, 1999.
10. Cohen T, Nahari D, Cerem LW, Neufeld G, and Levi BZ. Interleukin 6 induces the expression of vascular endothelial growth factor. J Biol Chem 271: 736-741, 1996.
11. Dignam JD, Lebovitz RM, and Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11: 1475-1489, 1983.
12. El Awad BB, Kreft BB, Wolber EM, Hellwig-Burgel T, Metzen E, Fandrey J, and Jelkmann W. Hypoxia and interleukin-1β stimulate vascular endothelial growth factor production in human proximal tubular cells. Kidney Int 58: 43-50, 2000.
13. Frank S, Hubner G, Breier G, Longaker MT, and Greenhalgh GT. Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing. J Biol Chem 270: 12607-12613, 1995.
14. Haddad JJ, and Land SC. A non-hypoxic, ROS-sensitive pathway mediates TNF-alpha-dependent regulation of HIF-1α. FEBS Lett 505: 269-274, 2001.
15. Hellwig-Burgel T, Rutkowski E, Metzen E, Fandrey J, and Jelkmann W. Interleukin-1β and tumor necrosis factor-α stimulate DNA binding of hypoxia-inducible factor-1. Blood 94: 1561-1567, 1999.
16. Hong Y, Suzuki S, Yatoh S, Mizutani M, Nakajima T, Bannai S, Sato H, Soma M, Okuda Y, and Yamada N. Effect of hypoxia on nitric oxide production and its synthase gene expression in rat smooth muscle cells. Biochem Biophys Res Commun 268: 329-332, 2000.
17. Huang LE, Willmore WG, Gu J, Goldberg MA, and Bunn HF. Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling. J Biol Chem 274: 9038-9044, 1999.
18. 2 sensing. Science 292: 464-468, 2001.
19. 2 homeostasis by hypoxia-inducible factor 1α. Genes Dev 12: 149-162, 1998.
20. 2-regulated prolyl hydroxylation. Science 292: 468-472, 2002.
21. Jackson JR, Minton JAL, Ho ML, Wie N, and Winkler JD. Expression of vascular endothelial growth factor in synovial fibroblasts is induced by hypoxia and interleukin 1beta. J Rheumatol 24: 1253-1259, 1997.
22. Kallio PJ, Wilson WJ, O'Brien S, Makino Y, and Poellinger L. Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway. J Biol Chem 274: 6519-6525, 1999.
23. 2 consumption by immunostimulated Caco-2 cells. Am J Physiol Lung Cell Mol Physiol 282: L1082-L1091, 2002.
24. Kimura H, Weisz A, Kurashima Y, Hashimoto K, Ogura T, D'Acquisto F, Addeo R, Makuuchi M, and Esumi H. Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide. Blood 95: 189-197, 2000.
25. Kimura H, Weisz A, Ogura T, Hitomi Y, Kurashima Y, Hashimoto K, D'Acquisto F, Makuuchi M, and Esumi H. Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide. J Biol Chem 276: 2292-2298, 2001.
26. L'Her E and Sebert P. A global approach to energy metabolism in an experimental model of sepsis. Am J Respir Crit Care Med 164:1444-1447, 2001.
27. Li J, Perrella MA, Tsai JC, Yet SF, Hsieh CM, Yoshizuma M, Patterson C, Endege WO, Zhou F, and Lee ME. Induction of vascular endothelial growth factor gene expression by interleukin-1 beta in rat aortic smooth muscle cells. J Biol Chem 270: 308-312, 2002.
28. Liu Y, Christou H, Morita T, Laughner E, Semenza GL, and Kourembanas S. Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5′ enhancer. J Biol Chem 273: 15257-15262, 1998.
29. Mateo RB, Reichner JS, Mastrofancesco B, Kraft-Stolar D, and Albina JE. Impact of nitric oxide on macrophage glucose metabolism and glyceraldehyde-3-phosphate dehydrogenase activity. Am J Physiol Cell Physiol 268: C669-C675, 1995.
30. Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, and Ratcliffe PJ. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271-275, 1999.
31. McCormick CC, Li WP, and Calero M. Oxygen tension limits nitric oxide synthesis by activated macrophages. Biochem J 350: 709-716, 2000.
32. Moore WM, Webber RK, Jerome GM, Tjong FS, Misko TP, and Currie MG. L-N6-(1-iminoethyl)lysine: A selective inhibitor of inducible nitric oxide synthase. J Med Chem 37: 3886-3888, 1994.
33. Palmer LA, Gaston B, and Johns RA. Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: redox-dependent effect of nitrogen oxides. Mol Pharmacol 58: 1197-1203, 2001.
34. Peng JL, Zhang L, Drysdale L, and Fong GH. The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling. Proc Natl Acad Sci USA 97: 8386-8391, 2000.
35. Potoka DA, Nadler EP, Zhou X, Zhang XR, Upperman JS, and Ford HR. Inhibition of NF-kappaB by IkappaB prevents cytokine-induced NO production and promotes enterocyte apoptosis in vitro. Shock 14: 366-373, 2000.
36. Salceda S and Caro J. Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272: 22642-22647, 2002.
37. Sandau KB, Fandrey J, and Brune B. Accumulation of HIF-1α under the influence of nitric oxide. Blood 97: 1009-1015, 2001.
38. Sandau KB, Faus HG, and Brune B. Induction of hypoxiainducible-factor 1 by nitric oxide is mediated via the P13K pathway. Biochem Biophys Res Commun 278: 263-267, 2000.
39. Sandau KB, Zhou J, Kietzmann T, and Brune B. Regulation of the hypoxia-inducible factor 1α by the inflammatory mediators nitric oxide and tumor necrosis factor-α in contrast to desferroxamine and phenylarsine oxide. J Biol Chem 276: 39805-39811, 2001.
40. 2 hemostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 15: 551-578, 1999.
41. Semenza GL, Jiang BH, Leung SW, Passantino R, Conordet JP, Maire P, and Giallongo A. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 271: 32529-32537, 1996.
42. Semenza GL, Roth PH, Fang HM, and Wang GL. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 269: 23757-23763, 1994.
43. Semenza GL and Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12: 5447-5454, 1992.
44. Sogawa K, Numayama T, Ema M, Abe M, and FujiiKuriyama Y. Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia. Proc Natl Acad Sci USA 95: 7368-7373, 1998.
45. Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, and Harris AL. The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 157: 411-421, 2000.
46. Thornton RD, Lane P, Borghaei RC, Pease EA, Caro J, and Mochan E. Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts. Biochem J 350: 307-312, 2001.
47. Unno N and Fink MP. Intestinal epithelial hyperpermeability. Mechanisms and relevance to disease. Gastroenterol Clin North Am 27: 289-307, 1998.
48. Unno N, Menconi MJ, Smith M, and Fink MP. Nitric oxide mediates interferon-gamma-induced hyperpermeability in cultured human intestinal epithelial monolayers. Crit Care Med 23: 1170-1176, 1995.
49. 2 tension. Proc Natl Acad Sci USA 92: 5510-5514, 1995.
50. Wang GL and Semenza GL. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA 90: 4304-4308, 1993.
51. Yin JH, Yang DI, Ku G, and Hsu CY. iNOS expression inhibits hypoxia-inducible factor-1 activity. Biochem Biophys Res Commun 279: 30-34, 2000.
52. Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, and Simons JW. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res 59: 5830-5835, 1999.