Cerebral ischemia and free radical

Brain and Nerve

Volumn 55, Issue 3, 2003, Pages 201-213

  Asano, Takao ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis necrosis continuum; Free radical (FR); Nitrous oxide (NO), cerebral ischemia; Reactive oxygen species (ROS)

Indexed keywords

ADENOSINE TRIPHOSPHATE; APOPTOSIS INDUCING FACTOR; CASPASE 3; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FREE RADICAL; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NITRIC OXIDE SYNTHASE; NITROUS OXIDE; PROTEIN S100B; REACTIVE OXYGEN METABOLITE; STAT PROTEIN; STRESS ACTIVATED PROTEIN KINASE; THIOREDOXIN;

APOPTOSIS; BRAIN ISCHEMIA; CYTOKINE PRODUCTION; GAP JUNCTION; NERVE CELL NECROSIS; ONCOGENE RAS; PATHOPHYSIOLOGY; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; ASTROCYTES; BRAIN INFARCTION; BRAIN ISCHEMIA; FREE RADICALS; HUMANS; MITOCHONDRIA; NECROSIS; NEUROGLIA; NITRIC OXIDE; OXIDATION-REDUCTION; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 0037363971     PISSN: 00068969     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (92)

1. Ahlemeyer B, Beier H, Semkova I, Schaper C, Krieglstein J: S-100 β protects cultured neurons against glutamate- and staurosporine-induced damage and is involved in the antiapoptotic action of the 5-HT 1 A-receptor agonist, Bay x 3702. Brain Res 858: 121-128, 1999
2. Alessandrini A, Namura S, Moskowitz M, Bonvenre JV: MEK 1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia. Proc Natl Acad Sci U S A 96: 12866-12869, 1999
3. Asano T, Tateishi N, Matsui T, Mori T, Kagamiishi Y, Sato S, Katsube N: Functional modulation of astrocytes by a novel agent ONO-2506 mitigates delayed infarct expansion with a wide therapeutic time window, inducing prompt neurological recovery through reduction of the extracellular level of glutamate. In: Molecular Mechanism and Epochal Therapeutics for Ischemic Stroke and Dementia, Abe K(ed), Excerpta Medica International Congress Series, in press
4. Asano T, Matsui T, Morikawa E, Tateishi N, Kagamiishi Y, Satoh S, Kondo K: The ameliorative effect of ONO-2506 on the delayed and prolonged expansion of the infarct volume following permanent middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 119 (Suppl 1): S64, 1999
5. Baird A, Benfield A, Schlaug G, Siewert B, Lovblad KO, Edelman RR, Warach S: Enlargement of human cerebral ischemic lesion volume measured by diffusion-weighted magnetic resonance imaging. Ann Neurol 41: 581-589, 1997
6. Barone F, Feuerstein G: Inflammatory mediators and stroke: New opportunities for novel therapeutics. J Cereb Blood Flow Metab 19: 819-834, 1999
7. Beaulieu C, de Crespigny A, Tong D, Moseley ME, Albers GW, Marks MP: Longitudinal magnetic resonance imaging study of perfusion and diffusion in stroke: evolution of lesion volume and correlation with linical outcome. Ann Neurol 46: 568-578, 1999
8. Boveris A, Cadenas E: Mitochondrial production of hydrogen peroxide regulation by nitric oxide and the role of ubisemiquinone. IUBMB Life 50: 245-250, 2000
9. Buttke T, Sandstrom P: Oxidative stress as a mediator of apoptosis. Immunol Today 15: 7-10, 1994
10. Cao X, Phillis J: Alpha-Phenyl-tert-butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia. Brain Res 644: 267-272, 1994
11. Chan P: Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 21: 2-14, 2001
12. Chandel N, Schumackeer P: Cellular oxygen sensing by mitochondria: old questions, new insight. J Appl Physiol 88: 1880-1889, 2000
13. Christman J, Blackwell T, Juurlink B: Redox regulation of nuclear factor kappa B: therapeutic potential for attenuating inflammatory responses. Brain Pathol 10: 153-162, 2000
14. Cotrina M, Kang J, Lin J-C, Bueno E, Hansen TW, He L, Liu Y, Nedergaard M: Astrocytic gap junctions remain open during ischemic conditions. J Neurosci 18: 2520-2537, 1998
15. Dalton T, Shertzer H, Puga A: Regulation of gene expression by reactive oxygen. Annu Rev Pharmacol Toxicol 39: 67-101, 1999
16. Dawson D, Masayasu H, Graham D, Macrae I: The neuroprotective efficacy of ebselen (a glutathione peroxidase mimic) on brain damage induced by transient focal cerebral ischaemia in the rat. Neurosci Lett 185: 65-69, 1995
17. Demopoulos H, Flamm E, Seligman M, Poser R, Pietronigro O, Ransohoff J: Molecular pathology of lipids in CNS membranes. In: Oxgen And Physiological Function (Joebsis FF. ed). Professional Information Library, Dallas, pp 491-508, 1977
18. Dirnagl U, Iadecola C, Moskowitz M: Pathobiology of ischaemic stroke: an integrated view. TINS 22: 391-397, 1999
19. Donato R: Functional roles of S 100 proteins, calcium-binding proteins of the EF-hand type. Biochim Biophys Acta 1450: 191-231, 1999
20. Du C, Hu R, Csernansky C, Liu X, Hsu C, Choi D: Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis? J Cereb Blood Flow Metab 16: 195-201, 1996
21. Eddeleston M, Mucke L: Molecular profile of reactive astrocytes - Implications for their role in neurological disease. Neuroscience 1: 15-36, 1993
22. Endres M, Wang Z, Namura S, Waeber C, Moskowitz MA: Ischemic injury is mediated by the activation of Poly (ADP-ribose) polymerase. J Cereb Blood Flow Metab 17: 1143-1151, 1997
23. Ferri K, Kroemer G: Organelle-specific initiation of cell death pathways. Nature Cell Biology 3: E255-E 263, 2001
24. Finkel T: Reactive oxygen species and signal transduction. IUBMB Life 52: 3-6, 2001
25. Fiskum G, Murphy A, Beal M: Mitochondria in neurodegeneration: acute ischemia and chronic neurodegenerative diseases. J Cereb Blood Flow Metab 19: 351-369, 1999
26. -. J Biol Chem 268: 22369-22376, 1993
27. Floyd R: Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development. Free Radic Biol Med 26(9-10): 1346-1355, 1999
28. Folbergrova J, Zhao Q, Katsura K, Siesjo BK: N-tert-butyl-alpha-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia, Proc Natl Acad Sci U S A 92: 5057-5061, 1995
29. Galis Z, Khatri J: Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circ Res 90: 251-262, 2001
30. Gladilin S, Bidmon H, Divanach A, Arteel GE, Witte OW, Zilles K, Sies H: Ebselen lowers plasma interleukin-6 levels and glial heme oxygenase-1 expression after focal photothrombotic brain ischemia. Arch Biochem Biophys 380: 237-242, 2000
31. Gonzalez-Flecha B, Demple B: Homeostatic regulation of intracellular hydrogen peroxide concentration in aerobically growing Escherichia coli. J Bacteriol 179: 382-388, 1997
32. Gonzalez-Flecha B, Demple B: Metabolic sources of H202 in aerobically growing E. coli. J Biol Chem 270: 13681-13687, 1995
33. Graham D: Hypoxia and vascular disorders. In: Greenfield's Neuropathology, Adams, JH, duchen, LW, eds. Oxford University Press, New York. pp 153-268, 1992
34. Griendling K, Ushio-Fukai M, Lassegue B, Alexander RW: Angiotensin II. Signaling in vascular smooth muscle. New concepts. Hypertension 29: 366-373, 1997
35. Halliwell B, Gutteridge J: Free Radicals in Biology and Medicine. Oxford University Press, Oxford. 1985
36. Halliwell B, Gutteridge J: Free Radicals in Biology and Medicine. IIIrd Edition. Oxford University Press, Oxford, UK. 1999
37. Heizmann C, Cox J: New perspectives on S 100 proteins: a multi-functional Ca(2+)-, Zn(2+)-, and Cu (2+)-binding protein family. Biometals 11: 383-397, 1998
38. Hoehn-Berlage M, Norris D, Kohno K, Miles G, Leibfritz D, Hossman KA: Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances. J Cereb Blood Flow Metab 15: 1002-1011, 1995
39. Holmgren A: Antioxidant function of thioredoxin and glutaredoxin systems. Antioxidants & Redox signaling 2: 811-820, 2000
40. Hu J, Castets F, Guevara J, Van Eldik LJ: S 100 beta stimulates inducible nitric oxide synthase activity and mRNA levels in rat cortical astrocytes. J Biol Chem 271: 2543-2547, 1996a
41. Hu J, Van Eldik L: S 100 beta induces apoptotic cell death in cultured astrocytes via a nitric oxide-dependent pathway. Biochim Biophys Acta 1313: 239-245, 1996b
42. Iadecola C: Bright and dark sides of nitric oxide in ischemic brain injury. TINS 20: 132-139, 1997
43. Ichikawa S, Omura K, Katayama T, Okamura N, Ohtsuka T, Ishibashi S, Masayasu H: Inhibition of superoxide anion production in guinea pig polymophonuclear leukocytes by a seleno-organic compound, ebselen. J Pharmacobio-Dyn 10: 595-598, 1987
44. Imai H, Masayasu H, Dewar D, Graham DI, Macrae IM: Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia. Stroke 32: 2149-2154, 2001
45. Irani K: Oxidant signaling in vascular cell growth, death, and survival: a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling. Circ Res 87: 179-183, 2000
46. Irving E, Barone F, Reith A, Hadingham SJ, Parsons AA: Differential activation of MAPK/ERD and p 38/SAPK in neurones and glia following focal cerebral ischaemia in the rat. Mol Brain Res 77: 65-75, 2000
47. Kotake Y, Sang H, Miyajima T, Wallis GL: Inhibition of NF-kappaB, iNOS mRNA, COX 2 mRNA, and COX catalytic activity by phenyl-N-tert-butylnitrone (PBN). Biochim Biophys Acta 1448: 77-84, 1998
48. Kraig R, Lascola C, Caggiano A: Glial response to brain ischemia. In: Neuroglia, Kettermann H.; Ransom B.; eds, New York. Oxford University Press. pp 964-976, 1995
49. Legos J, Erhardt J, White R, Lenhard S, Chandra S, Parsons A, Tuma RF, Barone FC: SB 239063, a novel p 38 inhibitor, attenuates early neuronal injury following ischemia. Brain Res 892: 70-77, 2001
50. Li N, Karin M: Is NF-kappaB the sensor of oxidative stress? FASEB J 13: 1137-1143, 1999
51. Li P, He Q, Nakamura L, Csiszar K: Free radical spin trap alpha-phenyl-N-tert-butyl-nitron inhibits caspase-3 activation and reduces brain damage following a severe forebrain ischemic injury. Free Radic Biol Med 31: 1191-1197, 2001
52. Lipton P: Ischemic cell death in brain neurons. Physiol Rev 79: 1431-1568, 1999
53. Loihl A, Asensio V, Campbell I, Murphy S: Expression of nitric oxide synthase, NOS-2 following permanent focal ischemia ischeinia and the role of nitric oxide in infarct generation in male, female, and NOS-2 gene-deficient mice. Brain Res 830: 155-164, 1999
54. Lum H, Roebuck K: Oxidant stress and endothelial dysfunction. Am J Physiol Cell Physiol 280: C719-C 741, 2001
55. MacManus J, Linnik M: Gene expression induced by cerebral ischemia: an apoptotic perspective. J Cereb Blood Flow Metab 17: 815-832, 1997
56. Martin L, Al-Abdulla N, Brambrink A, Kirsch J, Sieber F, Porterra-Cailliau C: Neurodegeneration in excito-toxidity, global cerebral ischemia, and target deprivation: a perspective on the contributions of apoptosis and necrosis. Brain Res Bull 46: 281-309, 1998
57. Martins-Ferreira H, Nedergaard M, Nicholson C: Perspectives on spreading depression. Brain Res Brain Res Rev 32: 215-234, 2000
58. Matsui T, Johsita H, Tanaka J, Asano T: Effect of a free radical scavenger, ebselen, on cerebral ischemia. In: Pharmacology of Cerebral Ischemia. Krieglstein J, Oberpichler H, eds, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart. pp. 363-368, 1990
59. Matsui T, Tateishi N, Kagamiishi Y, Satoh S, Katsube N, Mori T, Morikawa E, Morimoto T, Ikuta F, Asano T: Astrocytic activation and delayed infarct expansion following permanent focal ischemia in the rat. Part I: enhanced astrocytic synthesis of S-100 β in the periinfarct area precedes the occurrence of delayed infarct expansion. J Cereb Blood Flow Metab 22: 711-722, 2002
60. Moncada S, Palmer R, Higgs E: Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109-142, 1991
61. Murphy A, Fiskum G, Beal M: Mitochondria in neurodegeneration: bioenergetic function in cell life and death. J Cereb Blood Flow Metab 19: 231-245, 1999
62. Namura S, Nagata I, Takami S, Masayasu H, Kikuchi H: Ebselen reduces cytochrome c release from mitochondria and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Stroke 32: 1906-1911, 2001
63. Nedergaard M, Cooper A, Goldman S: Gap junctions are required for the propagation of spreading depression. J Neurobiol 28: 433-444, 1995
64. Nedergaard M, Hansen A: Spreading depression is not associated with neuronal injury in the normal brain. Brain Res 449: 395-398, 1988
65. Nordberg J, Arnèr E: Reactive oxyen species, antioxidants, and the mammalian thioredoxin system. Free Radic Biol Med 31: 1287-1312, 2001
66. Ogawa A, Yoshimoto T, Kikuchi H, Sano K, Abe H, Hashi K, Takakura K, Saito I, Yamaguchi T, Yasuhara H: Ebselen in acute middle cerebral artery occlusion: a placebo-controlled, double-blind clinical trial. Cerebrovas Dis. Cerebrovasc Dis 9: 112-118, 1999
67. Parnham M, Sies H: Ebselen: Prospective therapy for cerebral ischaemia. Exp Opin Invest Drugs 9: 607-619, 2000
68. Portera-Cailliau C, Price D, Martin D: Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum. J Comp Neurol 378: 70-87, 1997a
69. Portera-Cailliau C, Price D, Martin L: Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: further evidence for an apoptosis-necrosis contnuum. J Comp Neurol 378b: 88-104, 1997b
70. Rawanduzy A, Hansen A, Hansen T, Nedergaard M: Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke. J Neurosurg 87: 916-920, 1997
71. Sakowitz O, Wolfrum S, Sarrafzadeh A, Stover J, Dreier J, Dendorfer A, Benndorf G, Lanksch W, Unterberg A: Relation of cerebral energy metabolism and extracellular nitrite and nitrate concentrations in patients after aneurysmal subarachnoid hemorrhage. J Cereb Blood Flow Metab 21: 1067-1076, 2001
72. Schmidt K, Armstad P, Cerutti P, Baeuerle P: The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NFkB. Biol Chem 2:13-22, 1995
73. Schmidt-Kastner R, Szymas J, Hossmann K-A: Immunohistochemical study of glial reaction and serum-protein extravasation in relation to neuronal damage in rat hippocampus after ischemia. Neuroscience 38: 527-540, 1990
74. Selinfreund R, Barger S, Pledger W, Van Eldik L: Neurotrophic protein S 100 b stimulates glial cell proliferation. Proc Natl Acad Sci U S A 88: 3554-3558, 1991
75. Sen C: Redox signaling and the emerging therapeutic potential of thiol antioxidants. Biochem Pharmacol 55: 1747-1758, 1998
76. Sen C, Packer L: Antioxidant and redox regulation of gene transcription. FASEB J 10: 709-720, 1996
77. Sies H, Arteel G: Interaction of peroxynitrite with selenoproteins and glutathione peroxidase mimics. Free Radic Biol Med 28: 1451-1455, 2000
78. Siesjö BK: Cell damage in the brain: A speculative synthesis. J Cereb Blood Flow Metab 1: 155-185, 1981
79. Stamler J, Singel D, Loscalzo J: Biochemistry of nitric oxide and its redox-activated forms. Science 258: 1898-1902, 1992
80. Tamura A, Graham D, McCulloch J, Teasdale G: Focal cerebral ischemia in the rat. 2. Regional cerebral blood flow determined by (14 C) iodoantipyrine autoradiography following middle cerebral artery occlusion. J Cereb Blood Flow Metab 1: 61-69, 1981
81. Tateishi N, Mori T, Kagamiishi Y, Satoh S, Katsube N, Morikawa E, Morimoto T, Matsui T, Asano T: Astrocytic activation and delayed infarct expansion following permanent focal ischemia in rats. Part II: suppression of astrocytic activation by a novel agent (R)-(-)-2 propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early improvement of neurological deficits. J Cereb Blood Flow Metab 22: 723-734, 2002
82. Tsuji M, Inanami O, Kuwabara M: Neuroprotective effect of alpha-phenyl-N-tert-butylnitrone in gerbil hippocampus is mediated by the mitogen-activated protein kinase pathway and heat shock proteins. Neurosci Lett 282: 41-44, 2000
83. van Dorsten F, Hata R, Maeda K, Franke C, Eis M, Hossman KA, Hoehn M: Diffusion- and perfusion-weighted MR imaging of transient focal cerebral ischaemia in mice. NMR Biomed 12: 525-534, 1999
84. Van Eldik L, Griffin W: S 100 beta expression in Alzheimer's disease: relation to neuropathology in brain regions. Biochim Biophy Acta 1223: 398-403, 1994
85. Warach S, Gaa J, Siewert B, Wielopolski P, Edelman R: Acute human stroke studied by whole brain echo planar diffusion-weighted magnetic resonance imaging. Ann Neurol 37: 231-241, 1995
86. White B, Sullivan J, DeGracia D, O'Neil BJ, Neumar RW, Grossman LL, Rafols JA, Krause GS: Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J Neurol Sci 179: 1-33, 2000
87. Yamaguchi T, Sano K, Takakura K, Saito I, Shinohara Y, Asano T, Yasuhara H: Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Stroke 29: 12-17, 1998
88. Yue T-L, Gu J-L, Lysko P, Cheng H-Y, Barone FC, Feurstein G: Neuroprotective effect of phenyl-t-butyl nitrone in gerbil global brain ischemia and in cultured rat cerebellar neurons. Brain Res 574: 193-197, 1992
89. Zhao Q, Pahlmark K, Smith M, Siesjo B: Delayed treatment with the spin trap alpha-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats. Acta Physiol Scand 152: 349-350, 1994
90. Zhao R, Holmgren A: A novel antioxidant mechanism of ebselen involving ebselen diselenide, a substrate of mammalian thioredoxin and thioredoxin reductase. J Biol Chem 277: 39456-39462, 2002a
91. Zhao R, Masayasu H, Holmgren A: Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant. Proc Natl Acad Sci U S A 99: 8579-8584, 2002b