SB 239063, a novel p38 inhibitor, attenuates early neuronal injury following ischemia

Brain Research

Volumn 892, Issue 1, 2001, Pages 70-77

  Legos, Jeffrey J ^a,b   Erhardt, Joseph A ^a   White, Raymond F ^a   Lenhard, Stephen C ^a   Chandra, Sudeep ^a   Parsons, Andrew A ^a   Tuma, Ronald F ^b   Barone, Frank C ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Focal ischemia; Neuronal Injury; Neuroprotection; p38 MAPK; Stroke

Indexed keywords

4 [4 (4 FLUOROPHENYL) 5 (2 METHOXY 4 PYRIMIDINYL) 1 IMIDAZOLYL]CYCLOHEXANOL; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE INHIBITOR; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN ISCHEMIA; BRAIN SIZE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE RESPONSE; DOSE TIME EFFECT RELATION; IMMUNOBLOTTING; INFLAMMATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; CELL DEATH; CEREBRAL INFARCTION; ENZYME INHIBITORS; IMIDAZOLES; ISCHEMIC ATTACK, TRANSIENT; MALE; MIDDLE CEREBRAL ARTERY; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIMIDINES; RATS; RATS, INBRED SHR;

EID: 0035895803     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)03228-5     Document Type: Article

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