UVB-induced Cyclobutane Pyrimidine Dimer Frequency Correlates with Skin Cancer Mutational Hotspots in p53

Photochemistry and Photobiology

Volumn 66, Issue 5, 1997, Pages 719-726

  Drouin, Régen ^a,b   Therrien, Jean Philippe ^a  

^a UNIVERSITÉ LAVAL   (Canada)

^b U de Rech en Genet Hum et Molec   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PYRIMIDINE DIMER;

ARTICLE; CELL CULTURE; CHEMISTRY; GENETICS; HUMAN; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; RADIATION EXPOSURE; RADIATION INJURY; SKIN TUMOR; TUMOR SUPPRESSOR GENE; ULTRAVIOLET RADIATION;

BASE SEQUENCE; CELLS, CULTURED; DNA; GENES, P53; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASMS, RADIATION-INDUCED; PYRIMIDINE DIMERS; SKIN NEOPLASMS; ULTRAVIOLET RAYS;

EID: 0031267083     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1751-1097.1997.tb03213.x     Document Type: Article

References (39)

1. Glass, A. G. and R. N. Hoover (1989) The emerging epidemic of melanoma and squamous cell skin cancer. J. Am. Med. Assoc. 262, 2097-2100.
2. Brash, D. E. (1988) UV mutagenic photoproducts in Escherichia coli and human cells: a molecular genetics perspective on human skin cancer. Photochem. Photobiol. 48, 59-66.
3. Urbach, F. (1989) Potential effects of altered solar ultraviolet radiation on human skin cancer. Photochem. Photobiol. 50, 507-513.
4. Cadet, J., C. Anselmino, T. Douki and L. Voituriez (1992) Photochemistry of nucleic acids in cells. J. Photochem. Photobiol. B Biol. 15, 277-298.
5. LeClerc, J. E., A. Borden and C. W. Lawrence (1991) The thymine-thymine pyrimidine-pyrimidone(6-4) ultraviolet light photoproduct is highly mutagenic and specifically induces 3′ thymine-to-cytosine transitions in Escherichia coli. Proc. Natl. Acad. Sci. USA 88, 9685-9689.
6. Protic-Sabljic, M., N. Tuteja, P. J. Munson, J. Hauser, K. H. Kraemer and K. Dixon (1986) UV light-induced cyclobutane pyrimidine dimers are mutagenic in mammalian cells. Mol. Cell. Biol. 6, 3349-3356.
7. Jiang, N. and J. S. Taylor (1993) In vivo evidence that UV-induced C → T mutations at dipyrimidine sites could result from the replicative bypass of cis-syn cyclobutane dimers or their deamination products. Biochemistry 32, 472-481.
8. Gibbs, P. E. M., A. Borden and C. W. Lawrence (1995) The T-T pyrimidine (6-4) pyrimidinone UV photoproduct is much less mutagenic in yeast than in Escherichia coli. Nucleic Acids Res. 23, 1919-1922.
9. Ziegler, A., A. S. Jonason, D. J. Leffell, J. A. Simon, H. W. Sharma, J. Kimmelman, L. Remington, T. Jacks and D. E. Brash (1994) Sunburn and p53 in the onset of skin cancer. Nature 372, 773-776.
10. Daya-Grosjean, L., N. Dumaz and A. Sarasin (1995) The specificity of p53 mutation spectra in sunlight induced human cancers. J. Photochem. Photobiol. B Biol. 28, 115-124.
11. Nataraj, A. J., J. C. Trent II and H. N. Ananthaswamy (1995) p53 gene mutations and photocarcinogenesis. Photochem. Photobiol. 62, 218-230.
12. Brash, D. E., J. A. Rudolph, J. A. Simon, A. Lin, G. J. McKenna, H. P. Baden, A. J. Halperin and J. Pontén (1991) A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc. Natl. Acad. Sci. USA 88, 10124-10128.
13. Ziegler, A., D. J. Leffell, S. Kunala, H. W. Sharma, M. Gailani, J. A. Simon, A. J. Halperin, H. P. Baden, P. E. Shapiro, A. E. Bale and D. E. Brash (1993) Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers. Proc. Natl. Acad. Sci. USA 90, 4216-4220.
14. Thilly, W. J. (1983) Analysis of chemically induced mutation in single cell populations. In Induced Mutagenesis, Molecular Mechanisms and Their Complications for Environmental Protection (Edited by C. W. Lawrence), pp. 337-378. Plenum Press, New York.
15. Tornaletti, S. and G. P. Pfeifer (1994) Slow repair of pyrimidine dimers at p53 mutation hotspots in skin cancer. Science 263, 1436-1438.
16. Tornaletti, S., D. Rozek and G. P. Pfeifer (1993) The distribution of UV photoproducts along the human p53 gene and its relation to mutations in skin cancer. Oncogene 8, 2051-2057.
17. Drobetsky, E. A., J. Turcotte and A. Châteauneuf (1995) A role for ultraviolet A in solar mutagenesis. Proc. Natl. Acad. Sci. USA 92, 2350-2354.
18. Drouin, R., S. Gao and G. P. Holmquist (1996) Agarose gel electrophoresis for DNA damage analysis. In Technologies for Detection of DNA Damage and Mutations (Edited by G. P. Pfeifer), pp. 37-43. Plenum Press, New York.
19. Drouin, R., H. Rodriguez, G. P. Holmquist and S. A. Akman (1996) Ligation-mediated PCR for analysis of oxidative DNA damage. In Technologies for Detection of DNA Damage and Mutations (Edited by G. P. Pfeifer), pp. 211-225. Plenum Press, New York.
20. Pfeifer, G. P., R. Drouin, A. D. Riggs and G. P. Holmquist (1992) Binding of transcription factors creates hot spots for UV photoproducts in vivo. Mol. Cell. Biol. 12, 1798-1804.
21. Tornaletti, S. and G. P. Pfeifer (1996) Ligation-mediated PCR for analysis of UV damage. In Technologies for Detection of DNA Damage and Mutations (Edited by G. P. Pfeifer), pp. 199-209. Plenum Press, New York.
22. Pfeifer, G. P. and A. D. Riggs (1993) Genomic footprinting by ligation mediated polymerase chain reaction. In PCR Protocols: Current Methods and Applications. Methods in Molecular Biology, Vol. 15 (Edited by B. White), pp. 153-168. Humana Press, Totowa, NJ.
23. Pfeifer, G. P. and A. D. Riggs (1993) Genomic sequencing. In DNA Sequencing Protocols. Methods in Molecular Biology, Vol. 23 (Edited by G. H. Griffin and A. M. Griffin), pp. 169-181. Humana Press, Totowa, NJ.
24. Maxam, A. M. and W. Gilbert (1980) Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol. 65, 499-560.
25. Iverson, B. L. and P. B. Dervan (1987) Adenine specific DNA chemical sequencing reaction. Nucleic Acids Res. 19, 7823-7830.
26. Mitchell, D. L., J. Jen and J. E. Cleaver (1992) Sequence specificity of cyclobutane pyrimidine dimers in DNA treated with solar (ultraviolet B) radiation. Nucleic Acids Res. 20, 225-229.
27. Gale, J. M., K. A. Nissen and M. J. Smerdon (1987) UV-induced formation of pyrimidine dimers in nucleosome core DNA is strongly modulated with a period of 10.3 bases. Proc. Natl. Acad. Sci. USA 84, 6644-6648.
28. Gale, J. M. and M. J. Smerdon (1990) UV induced (6-4) photoproducts are distributed differently than cyclobutane dimers in nucleosomes. Photochem. Photobiol. 51, 411-417.
29. Pfeifer, G. P., R. Drouin, A. D. Riggs and G. P. Holmquist (1991) In vivo mapping of a DNA adduct at nucleotide resolution: detection of pyrimidine (6-4) pyrimidone photoproducts by ligation-mediated polymerase chain reaction. Proc. Natl. Acad. Sci. USA 88, 1374-1378.
30. Tornaletti, S. and G. P. Pfeifer (1995) Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers Oncogene 10, 1493-1499.
31. Tornaletti, S. and G. P. Pfeifer (1995) UV light as a footprinting agent: modulation of UV-induced DNA damage by transcription factors bound at the promoters of three human genes. J. Mol. Biol. 249, 714-728.
32. Tornaletti, S., S. Bates and G. P. Pfeifer (1996) A high-resolution analysis of chromatin structure along p53 sequences. Mol. Carcinogenesis 17, 192-201.
33. Brown, D. W., L. J. Libertini, C. Suquet, E. W. Small and M. J. Smerdon (1993) Unfolding of nucleosome cores dramatically changes the distribution of ultraviolet photoproducts in DNA. Biochemistry 32, 10527-10531.
34. Suquet, C. and M. J. Smerdon (1993) UV damage to DNA strongly influences its rotational setting on the histone surface of reconstituted nucleosomes. J. Biol. Chem. 268, 23755-23757.
35. Schieferstein, U. and F. Thoma (1996) Modulation of cyclobutane pyrimidine dimer formation in a positioned nucleosome containing poly(dA.dT) tracts. Biochemistry 35, 7705-7714.
36. Tessman, I., M. A. Kennedy and S.-K. Liu (1994) Unusual kinetics of uracil formation in single and double-stranded DNA by deamination of cytosine in cyclobutane pyrimidine dimers. J. Mol. Biol. 235, 807-812.
37. Douki, T. and J. Cadet (1994) Formation of cyclobutane dimers and (6-4) photoproducts upon far-UV photolysis of 5-methylcytosine-containing dinucleoside monophosphates. Biochemistry 33, 11942-11950.
38. Tessman, I., S.-K. Liu and M. A. Kennedy (1992) Mechanism of SOS mutagenesis of UV-irradiated DNA: mostly error-free processing of deaminated cytosine. Proc: Natl. Acad. Sci. USA 89, 1159-1163.
39. Denissenko, M. F., J. X. Chen, M. Tang and G. P. Pfeifer (1997) Cytosine methylation determines hot spots of DNA damage in the human p53 gene. Proc. Natl. Acad. Sci. USA 94, 3893-3898.