COMPARE: A web accessible tool for investigating mechanisms of cell growth inhibition

Journal of Molecular Graphics and Modelling

Volumn 20, Issue 4, 2002, Pages 297-303

  Zaharevitz, Daniel W ^a   Holbeck, Susan L ^a   Bowerman, Christopher ^a   Svetlik, Penny A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Antitumor drugs; Cell based screening; COMPARE; Correlation analysis; Drug discovery

Indexed keywords

ALGORITHMS; CELL CULTURE; TUMORS;

DEVELOPMENTAL THERUPATIC PROGRAM (DTP);

MOLECULAR GRAPHICS;

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 5,6 DIHYDRO 2,3 DIMETHOXY 6 METHYL 8,9 METHYLENEDIOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; ANTINEOPLASTIC AGENT; AZATOXIN; BREQUINAR; CAMPTOTHECIN; FLAVOPIRIDOL; KENPAULLONE; NSC 665564; NSC 678519; NSC 679828; OLOMOUCINE; REDOXAL; S 649890; UNCLASSIFIED DRUG;

ALGORITHM; ANALYTIC METHOD; ANTINEOPLASTIC ACTIVITY; CANCER CENTER; CANCER INHIBITION; CELL GROWTH; COMPUTER PROGRAM; CONFERENCE PAPER; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; INFORMATION PROCESSING; PRIORITY JOURNAL; TUMOR CELL LINE;

ALGORITHMS; ANTINEOPLASTIC AGENTS; DATA INTERPRETATION, STATISTICAL; DATABASES, FACTUAL; DRUG EVALUATION, PRECLINICAL; GROWTH INHIBITORS; HUMANS; INTERNET; LINEAR MODELS; SOFTWARE; TUMOR CELLS, CULTURED;

EID: 0036136167     PISSN: 10933263     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1093-3263(01)00126-7     Document Type: Article

References (30)

1. New colorimetric cytotoxicity assay for anticancer-drug screening
2. Feasibility of a high-flux anticancer drug screen utilizing a diverse panel of human tumor cell lines in culture
3. Data display and analysis strategies for the NCI disease-oriented in vitro antitumor drug screen
4. Display and analysis of patterns of differential activity of drugs against human tumor cell lines: Development of mean graph and COMPARE algorithm
5. The prediction of biochemical mechanism of action from the in vitro antitumor screen of the National Cancer Institute
6. A gene expression database for the molecular pharmacology of cancer
7. Systematic variation in gene expression patterns in human cancer cell lines
8. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor
9. A synthetic inhibitor of the mitogen-activated protein kinase cascade
10. Rational design and molecular effects of a new topoisomerase II inhibitor, azatoxin
11. Dual inhibition of topoisomerase II and tubulin polymerization by azatoxin: A novel cytotoxic agent
12. Azatoxin derivatives with potent and selective action on topoisomerase II
13. Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data
14. Cytotoxicity and characterization of an active metabolite of benzamide riboside: A novel inhibitor of IMP dehydrogenase
15. Site of action of two novel pyrimidine biosynthesis inhibitors accurately predicted by the COMPARE program
16. Identification of a novel inhibitor (NSC 665564) of dihydroorotate dehydrogenase with a potency equivalent to brequinar
17. Protein-linked DNA strand breaks induced by NSC 314622: A novel non-camptothecin topoisomerase I poison
18. Discovery and initial characterization of the paullones: A novel class of small-molecule inhibitors of cyclin-dependent kinases
19. Identification of epidermal growth factor receptor and c-erbB2 pathway inhibitors by correlation with gene expression patterns
20. Rhodamine efflux patterns predict P-glycoprotein substrates in the National Cancer Institute drug screen
21. Generation of a drug resistance profile by quantitation of MDR-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen
22. Identification of compounds with preferential inhibitory activity against low Nm23 expressing human breast carcinoma and melanoma cell lines