Cutting edge: IL-10-producing CD4+ T cells mediate tumor rejection

Journal of Immunology

Volumn 168, Issue 1, 2002, Pages 1-4

  Segal, B M ^a   Glass, D D ^a   Shevach, E M ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; INTERLEUKIN 10;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CELLULAR IMMUNITY; CONTROLLED STUDY; GLIOMA; IMMUNOMODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TUMOR CELL CULTURE; TUMOR REJECTION; VACCINATION;

EID: 0036134856     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.1.1     Document Type: Article

References (32)

1. + T-helper and a T-killer cell
2. Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors
3. Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases
4. An HLA-A2 polyepitope vaccine for melanoma immunotherapy
5. In vivo priming of two distinct antitumor effector populations: The role of MHC class I expression
6. + T cells in the antitumor immune response
7. Therapy of malignant astrocytoma
8. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
9. Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoabsorbant assay
10. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease
11. High level IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10
12. IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function
13. Interleukin-10 and the interleukin-10 receptor
14. + T cells and accompanied by overproduction of IL-12, IFN-γ and TNF-α
15. Interleukin-10-deficient mice develop chronic enterocolitis
16. Altered immune responses in interleukin 10 transgenic mice
17. Tumor-induced interleukin-10 inhibits type I immune responses directed at a tumor antigen as well as a non-tumor antigen present at the tumor site
18. Inhibition of interleukin-10 (IL-10) production from MOPC 315 tumor cells by IL-10 antisense oligodeoxynucleotides enhances cell-mediated immune responses
19. Staining of interleukin-10 predicts clinical outcome in patients with nasopharyngeal carcinoma
20. Selective expression of interleukin-10 gene within glioblastoma multiforme
21. Systemic administration of cellular IL-10 induces an effective, specific, and long-lived immune response against established tumors in mice
22. Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory
23. Interleukin-10 inhibits tumor metastasis, downregulates MHC class I, and enhances NK lysis
24. Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism
25. IL-10 gene transfer to intracranial 9L glioma: Tumor inhibition and cooperation with IL-2
26. A transgenic model to analyze the immunoregulatory role of IL-10 secreted by APCs
27. Interleukin-10 enhances the therapeutic effectiveness of a recombinant poxvirus-based vaccine in an experimental murine tumor model
28. Simultaneous exposure to interleukin-18 and interleukin-10 in vitro synergistically augments murine spleen natural killer cell activity
29. IL-10 enhances NK cell proliferation, cytotoxicity and production of IFN-γ when combined with IL-18
30. Interleukin 10 induces apoptotic cell death of B-chronic lymphocytic leukemia cells
31. Regulation of tumor growth and metastasis by interleukin-10: The melanoma experience
32. Expression of the chemokines IP-10 and Mig in IL-10 transduced tumors