Helicobacter pylori infection and gastric cancer

Current Opinion in Gastroenterology

Volumn 17, Issue SUPPL. 1, 2001, Pages

  El Omar, Emad M ^a   Malfertheiner, Peter ^b  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 4243277197     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

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2. Forman D. Lessons from on-going intervention studies. In: Helicobacter pylori: basic mechanisms to clinical cure 1998. Hunt RH, Tytgat GNJ (editors). Dordrecht: Kluwer; 1998. pp. 354-361.
3. Huang JQ, Sridhar S, Chen Y, Hunt RH. Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology 1998; 114:1169-1179.
4. You WC, Zhang L, Gail MH, et al. Gastric dysplasia and gastric cancer: Helicobacter pylori, serum vitamin C, and other risk factors. J Natl Cancer Inst 2000; 92:1607-1612. This paper provides insight into the largest and most eagerly awaited intervention trial from China.
5. Chen MJ, Chiou YY, Wu DC, Wu SL. Lifestyle habits and gastric cancer in a hospital-based case-control study in Taiwan. Am J Gastroenterol 2000; 95:3242-3249.
6. Siman JH, Forsgren A, Berglund G, Floren CH. Tobacco smoking increases the risk for gastric adenocarcinoma among Helicobacter pylori-infected individuals. Scand J Gastroenterol 2001; 36:208-213.
7. Russo A, Maconi G, Spinelli P, et al. Effect of lifestyle, smoking, and diet on development of intestinal metaplasia in H. pylori-positive subjects. Am J Gastroenterol 2001; 96:1402-1408.
8. Komoto K, Haruma K, Kamada T, et al. Helicobacter pylori infection and gastric neoplasia: correlations with histological gastritis and tumor histology. Am J Gastroenterol 1998;93:1271-1276.
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10. Karlson BM, Ekbom A, Wacholder S, et al. Cancer of the upper gastrointestinal tract among patients with pernicious anemia: a case-cohort study. Scand J Gastroenterol 2000; 35:847-851.
11. Yamagata H, Kiyohara Y, Aoyagi K, et al. Impact of Helicobacter pylori infection on gastric cancer incidence in a general Japanese population: the Hisayama study. Arch Intern Med 2000; 160:1962-1968.
12. Haruma K, Komoto K, Kamada T, et al. Helicobacter pylori infection is a major risk factor for gastric carcinoma in young patients. Scand J Gastroenterol 2000; 35:255-259. An important study on the role of H. pylori in gastric cancer of young adults is presented.
13. Miehlke S, Kirsch C, Agha-Amiri K, et al. The Helicobacter pylori vacA s1, m1 genotype and cagA is associated with gastric carcinoma in Germany, Int J Cancer 2000; 87:322-327.
14. Figueiredo C, Van Doorn LJ, Nogueira C, et al. Helicobacter pylori geno types are associated with clinical outcome in Portuguese patients and show a high prevalence of infections with multiple strains. Scand J Gastroenterol 2001; 36:128-135. This paper provides important insights into the molecular epidemiology of H. pylori infection.
15. El-Omar EM, Oien K, Murray LS, et al. Increased prevalence of precancerous changes in relatives of gastric cancer patients: critical role of H. pylori. Gastroenterology 2000; 118:22-30. This important study addresses physiological and morphological abnormalities in first-degree relatives of gastric cancer patients and the role of H. pylori in these.
16. Brenner H, Bode G, Boeing H. Helicobacter pylori infection among offspring-of patients with stomach cancer. Gastroenterology 2000; 118:31-35. This impressive study highlights the role of familial clustering of H. pylori as a potential explanation for familial clustering of gastric cancer.
17. ••] is presented, which puts things into perspective.
18. Saito K, Arai K, Mori M, et al. Effect of Helicobacter pylori eradication on malignant transformation of gastric adenoma. Gastrointest Endosc 2000; 52:27-32. Although dealing with small numbers, this work highlights the value of H. pylori eradication in advanced lesions as a means of preventing gastric cancer.
19. Uemura N, Mukai T, Okamoto S, et al. Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer. Cancer Epidemiol Biomarkers Prev 1997; 6:639-642.
20. Uemura N, Okamoto S. Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer in Japan. Gastroenterol Clin North Am 2000; 29:819-827. This is a very useful review on this subject and is complementary to these authors' original paper [19].
21. El-Omar EM, Carrington M, Chow WH, et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 2000; 404: 398-402. This paper provides the first demonstration of how host genetic factors could influence clinical outcome of H. pylori infection.
22. Xia HH, Talley NJ. Apoptosis in gastric epithelium induced by Helicobacter pylori infection: implications in gastric carcinogenesis. Am J Gastroenterol 2001; 96:16-26. This is an excellent review of the literature on the subject of apoptosis, H. pylori infection and carcinogenesis.
23. Parente F, Caselli M, Bianchi PG. Gastric apoptosis and Helicobacter pylori infection: an intricate matter. Scand J Gastroenterol 2001; 36:113-115.
24. Vorobjova T, Maaroos HI, Sipponen P, et al. Apoptosis in different compartments of antrum and corpus mucosa in chronic Helicobacter pylori gastritis. An 18-year follow-up study. Scand J Gastroenterol 2001; 36: 136-143. This important study provides considerable insight into the interplay between apoptotic index, gastritis, atrophy and H. pylori infection.
25. Obst B, Wagner S, Sewing KF, Beil W. Helicobacter pylori causes DNA damage in gastric epithelial cells. Carcinogenesis 2000; 21:1111-1115.
26. Fujioka T, Honda S, Tokieda M. Helicobacter pylori infection and gastric carcinoma in animal models. J Gastroenterol Hepatol 2000; 15(suppl): D55-D59. A useful review of animal models of H. pylori and gastric cancer is presented.
27. Osawa H, Sugano K, Iwamori M, et al. Comparative analysis of colonization of Helicobacter pylori and glycolipids receptor density in Mongolian gerbils and mice. Dig Dis Sci 2001; 46:69-74. If this study is confirmed, it will prove to be an important step in our understanding of the differential effects of H. pylori on different animal species, and perhaps humans.
28. Ogura K, Maeda S, Nakao M, et al. Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil. J Exp Med 2000; 192: 1601-1610. This very elegant study demonstrates the importance of H. pylori bacterial virulence factors in the pathogenesis of gastric lesions in Mongolian gerbils.