A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog

Diabetes

Volumn 45, Issue 11, 1996, Pages 1594-1604

  Sindelar, Dana K ^a   Balcom, James H ^a   Chu, Chang A ^a   Neal, Doss W ^a   Cherrington, Alan D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; FATTY ACID; GLUCAGON; GLUCOSE; GLYCEROL; INSULIN; LACTIC ACID; SOMATOSTATIN; TRACER;

ALGORITHM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; FEMALE; GLUCONEOGENESIS; GLUCOSE INFUSION; GLYCOGENOLYSIS; INSULIN INFUSION; ISOTOPE LABELING; LIVER METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL;

EID: 0029969117     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.45.11.1594     Document Type: Article

References (27)

1. Cherrington AD: The acute regulation of hepatic glucose output. In The Role of the Liver in Maintaining Glucose Homeostasis. Cherrington AD, Davis SN, Pagliassotti MJ, Eds. Austin, TX, R.G. Landes, 1994, p. 19-37
2. Prager R, Wallace P, Olefsky JM: Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects. Diabetes 36:607-611, 1987
3. Ader M, Bergman RN: Peripheral effects of insulin dominate suppression of fasting hyperglycemia. Am J Physiol 258:E1029-E1032, 1990
4. Giacca A, Fisher S, Shi ZQ, Gupta R, Lavina H, Lickley A, Vranic M: Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs. J Clin Invest 90:1769-1777, 1992
5. Fisher S, Shi ZQ, Lekas M, Vranic M, Giacca A: Inhibition of glucagon secretion represents a dominant mechanism of insulin's indirect suppression of hepatic glucose production (Abstract). Diabetes 42 (Suppl. 1):40A, 1993
6. Myers SR, Diamond MP, Adkins-Marshall BA, Williams PE, Stinsen R, Cherrington AD: Effects of small changes in glucagon on glucose production during a euglycemic, hyperinsulinemic clamp. Metabolism 40:66-71, 1991
7. Adkins BA, Myers SR, Hendrick GK, Stevenson RW, Williams PE, Cherrington AD: Importance of the route of intravenous glucose delivery on hepatic glucose balance in the conscious dog. J Clin Invest 79:557-565, 1987
8. Dobbins R, Davis S, Neal D, Cobelli C, Jaspan J, Cherrington A: Compartmental modeling of glucagon kinetics in the conscious dog. Metabolism 44:452-459, 1995
9. Myers SR, McGuiness OP, Neal DW, Cherrington AD: Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration. J Clin Invest 87:930-939, 1991
10. Goresky CA, Bach CG, Nadeau BE: Red cell carriage of label: its limiting effect on the exchange of materials in the liver. Cir Res 36:328-351, 1975
11. Lloyd B, Burrin J, Smythe P, Alberti KGMM: Enzymatic fluorometric continuous-flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-hydroxybutyrate. Clin Chem 24:1724-1729, 1978
12. Wasserman DH, Geer RJ, Williams PE, Lacy DB, Abumard NN: Interaction of gut and liver in nitrogen metabolism during exercise. Metabolism 40:307-314, 1991
13. Morgan CR, Lazarow AL: Immunoassay of insulin: two antibody system: plasma insulin of normal, subdiabetic, and diabetic rats. Am J Med Sci 257:415-419, 1963
14. Venkatakrishnan A, Abel MJ, Campbell RA, Donahue EP, Uselton TC, Flakoll PJ: Whole blood analysis of gluconeogenic amino acids of de novo gluconeogenesis using pre-column o-phthalaldehyde derivatization and high performance liquid chromatography. J Chromatography B: Biomed Appl 676:1-6, 1996
15. Leevy CM, Mendenhall CL, Lesko W, Howard MM: Estimation of hepatic blood flow with indocyanine green. J Clin Invest 41:1169-1179, 1962
16. Price CP, Lloyd B, Alberti KG: A kinetic spectrophotometric assay for rapid determination of acetoacetate in blood. Clin Chem 23:1893-1897, 1977
17. Finegood DT, Bergman RN, Vranic M: Modelling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps. Diabetes 37:1025-1034, 1988
18. Mari A: Estimation of the rate of appearance in the non-steady state with a two-compartment model. Am J Phys 263:E400-E415, 1992
19. Dobbins R, Davis S, Neal DW, Cobelli C, Cherrington AD: Pulsatility does not alter the response to a physiological increment in glucagon in the conscious dog. Am J Physiol 266:E467-E478, 1994
20. Moore MC, Cherrington AD, Cline G, Jones EM, Neal DW, Badet C, Shulman GI: Sources of carbon for hepatic glycogen synthesis in the conscious dog. J Clin Invest 88:578-587, 1991
21. Cherrington AD, Lacy WW, Chiasson JL: Effect of glucagon on glucose production during insulin deficiency in the dog. J Clin Invest 62:664-677, 1978
22. Connolly CC, Steiner KE, Stevenson RW, Neal DW, Williams PE, Alberti KGMM, Cherrington AD: Regulation of glucose metabolism by norepinephrine in conscious dogs. Am J Physiol 261:E764-E772, 1991
23. Buchanan KD, Mawhinney WAA: Glucagon release from isolated pancreas in streptozocin-treated rats. Diabetes 22:797-800, 1973
24. Samols E, Harrison J: Intraislet negative insulin-glucagon feedback. Metabolism 15:1443-1447, 1976
25. Honey RN, Fallon MB, Weir GG: Effects of exogenous insulin, glucagon, and somatostatin on islet hormone secretion in the perfused chicken pancreas. Metabolism 29:1242-1246, 1980
26. Ostenson CG: Regulation of glucagon release: effects of insulin on the pancreatic β-cell of the guinea pig. Diabetologia 17:325-330, 1979
27. Asplin CM, Paquette TL, Palmer JP: In vivo inhibition of glucagon secretion by paracrine beta cell activity in man. J Clin Invest 68:314-318, 1981