Oncogenes in leukemia: Historical background and therapeutic prospect;Oncogènes et leucémies: Historique et perspectives

Medecine/Sciences

Volumn 19, Issue 2, 2003, Pages 201-210

  Gisselbrecht, Sylvie ^a  

^a INSTITUT COCHIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; CYCLIN DEPENDENT KINASE 1; GENE PRODUCT; HYBRID PROTEIN; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR GATA 1; TYROSINE KINASE RECEPTOR;

APOPTOSIS; BURKITT LYMPHOMA; CANCER RESEARCH; CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; DISEASE COURSE; GENOME; HUMAN; LEUKEMIA; MOLECULAR BIOLOGY; MOLECULAR CLONING; NONHUMAN; ONCOGENE; ONCOGENE MYC; PATHOGENESIS; POINT MUTATION; REVIEW;

ANIMALIA;

EID: 0037321863     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.1051/medsci/2003192201     Document Type: Review

References (45)

1. Jonkers J, Berns A. Retroviral insertional mutagenesis as a strategy to identify cancer genes. Biochim Biophys Acta 1996; 1287: 29-57.
2. Mikkers H, Allen J, Knipscher P, et al. High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nat Genet 2002; 32: 153-9.
3. Lund AH, Turner G, Trubetskoy A, et al. Genome-wide retroviral tagging of genes involved in cancer in Cdkn2a-deficient mice. Nat Genet 2002; 32: 160-5.
4. Suszuki T, Shen H, Akagi K, et al. New genes involved in cancer identified by retrovirus tagging. Nat Genet 2002; 32: 166-74.
5. Look AT. Oncogenic transcription factors in the human acute leukemias. Science 1997; 278: 1059-64
6. Dalla-Favera R, Bregni M, Erikson J, et al. Human c-myc oncogene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci USA 1982; 79: 7824-7.
7. Taub R, Kirsch I, Morton C, et al. Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plastocytoma cell. Proc Natl Acad Sci USA 1982; 79: 7837-41.
8. Heisterkamp N, Stephenson JR, Groffen J, et al. Localization of the c-abl oncogene adjacent to a translocation breakpoint in chronic myelocytic leukemia. Nature 1983; 306: 239-42.
9. Rabbitts TH. Chromosomal translocations in human cancer. Nature 1994; 372: 143-9.
10. Rabbitts TH. Chromosomal translocation master genes, mouse models and experimental therapeutics. Oncogene 2001; 20: 5763-77.
11. Scandura JM, Boccuni P, Cammenga J, Nimer SD. Transcription factor fusions in acute leukemia. Oncogene 2002; 21: 3422-44.
12. Scheijen B, Griffin JD. Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease. Oncogene 2002; 21: 3314-33.
13. Zhu J, Emerson SG. Hematopoietic cytokines, transcription factors and lineage commitment. Oncogene 2002; 21: 3295-313
14. Künstle G, Laine J, Pierron G, et al. Identification of Akt association and oligomerisation domains of the Akt kinase coactivator TCL1. Mol Cell Biol 2002; 22: 1513-25.
15. Levy ER, Parganas E, Morishita K, et al. DNA rearrangements proximal to the EVI1 locus associated with the 3q21q26 syndrome. Blood 1994; 83: 1348-53.
16. Lallemand-Breitenbach V, Zhu J, de Thé H. La leucémie aiguë promyélocytaire: un paradigme des traitements ciblés sur l'oncogène? Med Sci 2001; 17: 14-22.
17. Poirel H, Bernard O. Implication des gènes du CBF dans la leucémogenèse. Hématologie 2000; 6: 30-6.
18. Golub TR, Barker GF, Lovett N, Gilliland DG. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 1994; 77: 307-16.
19. Morris SW, Kirstein MN, Valentine MB, et al. Fusion of a kinase gene, ALK, to a nuclear protein gene, NPM in non-Hodgkin's lymphoma. Science 1994; 263: 1281-4.
20. Popovici C, Adélaïde J, Ollendorff V, et al. Fibroblast growth factor receptor 1 is fused to FIN in stem cell myeloproliferative disorder with t(8;13) (p12;q12). Proc Natl Acad Sci USA 1998; 95: 5712-7.
21. Guasch G, Mack GJ, Popovici C, et al. FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9) (p12;q33). Blood 2000; 95: 1788-96.
22. Lacronique V, Boureux A, Valle VD, et al. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 1997; 278: 1309-12.
23. Kuno Y, Abe A, Emi N, et al. Constitutive activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12) (q22;p12). Blood 2001; 97: 1050-5.
24. Wiemels JL, Cazzaniga G, Daniotti M, et al. Prenatal origin of acute lymphoblastic leukemia in children. Lancet 1999; 354: 1499-503.
25. Mori H, Colman SM, Xiao Z, et al. Chromosome translocations and covert leukemic clones are generated during normal fetal development. Proc Natl Acad Sci USA 2002; 99: 8242-7.
26. Liu Y, Hernandez AM, Shibata D, Cortopassi GA. Bcl2 translocation frequency rises with age in humans. Proc Natl Acad Sci USA 1994; 91: 8910-4.
27. Biernaux C, Loos M, Sels A, Huez G, Stryckmans P. Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals. Blood 1995; 86: 3118-22.
28. Pabst T, Meuller BU, Zhang P, et al. Dominant-negative mutations of mutations of C/EBPα, encoding CCAAT/enhancer binding protein alpha, in acute myeloid leukemia. Nat Genet 2001; 27: 263-70.
29. Gombart AF, Hofmann WK, Kawana S, et al. Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias. Blood 2002; 99: 1332-40.
30. Mercher T, Coniat MB, Monni R, et al. Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. Proc Natl Acad Sci USA 2001; 98: 5776-9.
31. Ma Z, Morris SW, Valentine V, et al. RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 2001; 28: 220-1.
32. Shivadsani RA, Fujiwara Y, McDevitt MA, Orkin SH. A lineage-selective selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J 1997; 16: 3965-73.
33. Wechsler J, Greene M, McDevitt MA, et al. Acquired mutations in GATA 1 in the megakaryoblastic leukemia of Down syndrome. Nat Genet 2002; 32: 148-52.
34. Song WJ, Sullivan MG, Legare RD, et al. Haploinsuffiency of CBFA2 (AML1) causes familial thrombocytopenia with propensity to develop acute myelogenous leukemia (FPD/AML). Nat Genet 1999; 23: 166-75.
35. Brown L, Cheng JT, Chen Q, et al. Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia. EMBO J 1990; 9: 3343-51.
36. Cayuela JM, Madani A, Sanhes L, Stern MH, Sigaux F. Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia. Blood 1996; 87: 2180-6.
37. Neshat MS, Mellinghoff IK, Tran C, et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci USA 2001; 98: 10314-9.
38. +/- mice. Proc Natl Acad Sci USA 2001; 98: 10320-5.
39. Hideshima T, Richardson P, Chouhan D, et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 2001; 61: 3071-6.
40. Huettner CS, Zhang P, Van Etten RA, Tenen D. Reversibility of acute B-cell leukaemia induced by BCR-ABL1. Nat Genet 2000; 24: 57-60.
41. Felsher DW, Bishop M. Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell 1999; 4: 199-207.
42. Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR/ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001; 344: 1031-7.
43. Weisberg E, Boulton C, Kelly LM, et al. Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412. Cancer Cell 2002; 5: 433-43.
44. Liao AT, Chien MB, Shenoy N, et al. Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. Blood 2002; 100: 585-93.
45. Lallemand-Breitenbach V, Guillemin MC, Janin A, et al. Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia. J Exp Med 1999; 189: 1043-52.