Involvement of CBF genes in leucemogenesis;Implication des genes du CBF dans la leucemogenese

Hematologie

Volumn 6, Issue 1, 2000, Pages 30-36

  Poirel, Hélène ^a   Bernard, Olivier ^a  

^a FONDATION JEAN DAUSSET CEPH   (France)

Author keywords

CBF; Chromosomal translocation; Leukemia; Transcription factors

Indexed keywords

TRANSCRIPTION FACTOR;

CHROMOSOME TRANSLOCATION; GENE ACTIVATION; GENE ISOLATION; GENE STRUCTURE; HUMAN; LEUKEMOGENESIS; NONHUMAN; PROTEIN DNA INTERACTION; PROTEIN PROTEIN INTERACTION; REVIEW; TRANSCRIPTION REGULATION;

EID: 0034019641     PISSN: 12647527     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (30)

1. Meyers S, Hiebert SW. Indirect and direct disruption of transcriptional regulation in cancer E2F and AML-1 Crit Rev Eukaryot Gene Expr 1995 ; 5 365-83
2. Speck NA, Terryl S A new transcription factor family associated with human leukemias Crit Rev Eukaryot Gene Expr 1995 , 5 337-64
3. Speck NA, Stacy T, Wang Q, North T, Gu TL, Miller J, Binder M, Marin-Padilla M. Core-binding factor : a central player in hematopoiesis and leukemia Cancer Res 1999 ; 59 S1789-93
4. Daga A, Karlovich CA, Dumstrei K, Banerjee U. Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1. Genes Dev 1996 , 10 1194-205
5. Golling G, Li L, Pepling M, Stebbins M, Gergen JP Drosophila homologs of the proto-oncogene product PEBP2/CBF beta regulate the DNA-binding properties of Runt Mol Cell Biol 1996 , 16 932-42
6. Miyoshi H, Ohira M, Shimizu K, Mitani K, Hirai H, Imai T, Yokoyama K, Soeda E, Ohki M Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia. Nucleic Acids Res 1995 , 23 : 2762-9
7. Tanaka T, Kurokawa M, Ueki K, Tanaka K, Imai Y, Mitani K, Okazaki K, Sagata N, Yazaki Y, Shibata Y, Kadowaki T, Hirai H. The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability Mol Cell Biol 1996 ; 16 3967-9
8. Uchida H, Zhang J, Nimer SD AML1A and AML1B can transactivate the human IL-3 promoter J Immunol 1997 , 158 2251-8.
9. Levanon D, Goldstein RE, Bernstein Y, Tang H, Goldenberg D, Stifani S, Paroush Z, Groner Y Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. Proc Natl Acad Sci USA 1998 , 95 11590-5
10. Lutterbach B, Sun D, Schuetz J, Hiebert SW. The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein. Mol Cell Biol 1998 , 18 : 3604-11.
11. Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis Cell 1996 , 84 : 321-30
12. Wang Q, Stacy T, Binder M, Marin-Padilla M, Sharpe AH, Speck NA Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis Proc Natl Acad Sci USA 1996 ; 93 : 3444-9
13. Wang Q, Stacy T, Miller JD, Lewis AF, Gu TL, Huang X, Bushweller JH, Bories JC, Alt JW, Ryan G, Liu PP, Wynshaw Boris A, Binder M, Marin-Padilla M, Sharpe AH, Speck N The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell 1996 , 87 697-708
14. Nucifora G, Rowley JD. AML1 and the 8;21 and 3,21 translocations in acute and chronic myeloid leukemia. Blood 1995 ; 86 : 1-14.
15. Rubnitz JE, Pui CH, Downing JR. The role of TEL fusion genes in pediatric leukemias Leukemia 1999 , 13 : 6-13
16. Gamou T, Kitamura E, Hosoda F, Shimizu K, Shinohara K, Hayashi Y, Nagase T, Yokoyama Y, Ohki M The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family. Blood 1998 , 91 . 4028-37
17. Roulston D, Espinosa R 3rd, Nucifora G, Larson RA, Le Beau MM, Rowley JD CBFA2(AML1) translocations with novel partner chromosomes in myeloid leukemias association with prior therapy Blood 1998 , 92 . 2879-85
18. Osato M, Asou N, Abdalla E, Hoshino K, Yamasaki H, Okubo T, Suzushima H, Takatsuki K, Kanno T, Shigesada K, Ito Y Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias. Blood 1999 , 93 1817-24.
19. Lutterbach B, Westendorf JJ, Linggi B, Patten A, Moniwa M, Davie JR, Huynh KD, Bardwell VJ, Lavinsky RM, Rosenfeld RG, Glass C, Seto E, Hiebert SW. ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors Mol Cell Biol 1998 ; 18 7176-84.
20. Westendorf JJ, Yamamoto CM, Lenny N, Downing JR, Selsted ME, Hiebert SW The t(8,21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation. Mol Cell Biol 1998 , 18 : 322-33
21. Yergeau DA, Hetherington CJ, Wang Q, Zhang P, Sharpe AH, Binder M, Marin-Padilla M, Tenen DG, Speck DA, DE. Zhang Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nat Genet 1997 , 15 : 303-6
22. Okuda T, Cai Z, Yang S, Lenny N, Lyu CJ, van Deursen JM, Harada H, Downing JR Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors Blood 1998 ; 91 3134-43
23. Hiebert SW, Sun W, Davis JN, Golub J, Shurtleff S, Buijs A, Downing JR, Grosveld G, Roussell MF, Gilliland DG, Lenny N, Meyers S The t(12,21) translocation converts AML-1B from an activator to a repressor of transcription Mol Cell Biol 1996 ; 16 1349-55.
24. Nucifora G The EVI1 gene in myeloid leukemia Leukemia 1997 , 11 2022-31
25. Liu P, Tarle SA, Hajra A, Claxton DF, Mariton P, Freedman M, Siciliano MJ, Collins FS. Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Science 1993 , 261 1041-4.
26. Adya N, Stacy T, Speck NA, Liu PP. The leukemic protein core binding factor beta (CBF-beta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates Mol Cell Biol 1998 , 18 : 7432-43.
27. Castilla LH, Wijmenga C, Wang Q, Stacy T, Speck NA, Eckhaus M, Marin-Padilla M, Collins FS, Wynshaw-Boris A, Liu PP Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11 Cell 1996 , 87 : 687-96
28. Kogan SC, Lagasse E, Atwater S, Bae SC, Weissman I, Ito Y, Bishop JM. The PEBP2beta-MYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia Proc Natl Acad Sci USA 1998 ; 95 : 11863-18
29. Song WJ, Sullivan MG, Legare RD, Mutchings S, Tan X, Kufrin D, Ratajczak J, Resende IC, Haworth C, Hock R, Loh M, Felix C, Roy DC, Busque L, Kurnit D, Willman C, Gewirtz AM, Speck NA, Bushweller JH, Li FP, Gardiner K, Poncz M, Maris JM, Gilliland DG Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia Nat Genet 1999 , 23 : 166-75
30. Fero ML, Randel E, Gurley KE, Roberts JM, Kemp CJ. The murine gene p27Kip1 is haplo-insufficient for tumour suppression Nature 1998 , 396 177-80