CCL27/PESKY: A novel paradigm for chemokine function

Expert Opinion on Biological Therapy

Volumn 3, Issue 1, 2003, Pages 15-22

  Nibbs, Robert J B ^a   Graham, Gerard J ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

Chemokine; Inflammation; Migration; Nuclear targeting; T cell

Indexed keywords

ACTIN; BETA CHEMOKINE; CCL27 CHEMOKINE; CHEMOKINE RECEPTOR CCR1; UNCLASSIFIED DRUG;

CELL MOTILITY; CELL STRUCTURE; CYTOKINE RELEASE; CYTOSKELETON; INTERNALIZATION; LEUKOCYTE MIGRATION; MEMORY CELL; PROTEIN TARGETING; RECEPTOR BINDING; REVIEW; SKIN INFLAMMATION; STRESS FIBER; T LYMPHOCYTE SUBPOPULATION; TRANSCRIPTION REGULATION;

ALTERNATIVE SPLICING; ANIMALS; CHEMOKINES, CC; CHEMOTAXIS, LEUKOCYTE; HUMANS; NUCLEAR PROTEINS; PROTEIN ISOFORMS;

EID: 0037321305     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.3.1.15     Document Type: Review

References (47)

1. GERARD C, ROLLINS B: Chemokines and disease. Nat. Immunol (2001) 2:108-115.
2. MOSER B, LOETSCHER P: Lymphocyte traffic control by chemokines. Nat. Immunol. (2001) 2:123-128.
3. MACKAY C: Chemokines: immunology's high impact factors. Nat. Immunol. (2001) 2:95-101.
4. ROSSI D, ZLOTNIK A: The biology of chemokines and their receptors. Ann. Rev. Immunol. (2000) 18:217-242.
5. BERGER EA, MURPHY PM, FARBER JM: Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Ann. Rev. Immunol. (1999) 17:657-700.
6. GARZINO-DEMO A, DEVICO AL, CONANT KE, GALLO RC: The role of chemokines in human immunodeficiency virus infection. Immunol. Rev. (2000) 177:79-87.
7. O'BRIEN SJ, MOORE JP: The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS. Immunol. Rev. (2000) 177:99-111.
8. BARCELLOS LF, SCHITO AM, RIMMLER JB et al.: CC-chemokine receptor 5 polymorphism and age of onset in familial multiple sclerosis. Multiple Sclerosis Genetics Group. Immunogenetics (2000) 51:281-288.
9. GOMEZ-REINO JJ, PABLOS JL, CARREIRA PE et al.: Association of rheumatoid arthritis with a functional chemokine receptor, CCR5. Arthritis Rheum. (1999) 42:989-992.
10. HALL IP, WHEATLEY A, CHRISTIE G, MCDOUGALL C, HUBBARD R, HELMS PJ: Association of CCR5Δ32 with reduced risk of asthma. Lancet (1999) 354:1264-1265.
11. MOATTI D, FAURE S, FUMERON F et al.: Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease. Blood (2001) 97:1925-1928.
12. ONUFFER JJ, HORUK R. Chemokines, chemokine receptors and small-molecule antagonists: recent developments. TIPS (2002) 23:459-467.
13. LUTHER SA, CYSTER JG: Chemokines as regulators of T cell differentiation. Nat. Immunol. (2001) 2:102-107.
14. GRAHAM GJ, WRIGHT EG, HEWICK R et al: Identification and characterization of an inhibitor of haemopoietic stem cell proliferation. Nature (1990) 344:442-444.
15. TACHIBANA K, HIROTA S, IZASA H et al.: The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature (1998) 393:591-595.
16. ZOU Y-R, KOTTMANN AH, KURODA M, TANIUCHI I, LITTMAN DR: Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature (1998) 393:595-599.
17. STREITER RM, DIGIOVINE B, POLVERINI PJ et al.: CXC chemokines and lung cancer angiogenesis. In Chemokines and Cancer. Rollins BJ (Ed.), Humana Press, Totowa, NJ, USA (1999):143-167.
18. BEZZI P, DOMERCQ M, BRAMBILLA L et al.: CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity. Nat. Neurosci. (2001) 4:702-710.
19. MEUCCI O, FATATIS A, SIMEN AA, MILLER RJ: Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. Proc. Natl. Acad. Sci. USA (2000) 97:8075-8080.
20. ANSEL KM, NGO VN, HYMAN PL et al.: A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature (2000) 406:309-314.
21. MULLERA, HOMEY B, SOTO H et al.: Involvement of chemokine receptors in breast cancer metastasis. Nature (2001) 410:50-56. Characterisation of chemokine receptor expression on breast cancer cells, and the demonstration that blocking one of these receptors, CXCR4, with neutralising antibodies, can reduce metastatic homing of these cells in nude mice.
22. YOUN BS, KIM YJ, MANTEL C, YU KY, BROXMEYER HE: Blocking of c-FLIP(L)-independent cycloheximide-induced apoptosis or Fas-mediated apoptosis by the CC chemokine receptor 9/TECK interaction. Blood (2001) 98:925-933.
23. BAIRD JW, NIBBS RJ, KOMAIKOMA M et al.: ESkine, a novel betachemokine, is differentially spliced to produce secretable and nuclear targeted isoforms. J. Biol. Chem. (1999) 274:33496-33503. One of the first reports of CCL27, and the first demonstration that nuclear-targeted chemokine variants (PESKY) can be generated by alternative splicing.
24. MORALES J, HOMEY B, VICARI AP et al.: CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc. Natl. Acad. Sci. USA (1999) 96:14470-14475.
25. HROMAS R, BROXMEYER HE, KIM C, CHRISTOPHERSON II K, HOU Y-H: Isolation of ALP, a novel divergent murine CC chemokine with a unique carboxy terminus. Biochem. Biophys. Res. Comm. (1999) 258:737-740.
26. ISHIKAWA-MOCHIZUKI I, KITAURA M, BABA M et al.: Molecular cloning of a novel CC chemokine, interleukin-11 receptor α-locus (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus. FEBS Lett. (1999) 460:544-548.
27. NO AUTHORS LISTED: Chemokine/Chemokine Receptor Nomenclature. J. Leukoc. Biol. (2001) 70:465-466.
28. HOMEY B, WANG W, SOTO H et al.: Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/1LC). J. Immunol. (2000) 164:3465-3470. Identification of the CCL27 receptor.
29. JARMIN DI, RITS M, BOTA D et al.: Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. J. Immunol. (2000) 164:3460-3464. Identification of the CCL27 receptor.
30. PAN J, KUNKEL EJ, GOSSLAR U et al.: A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. J. Immunol. (2000) 165:2943-2949.
31. WANG W, SOTO H, OLDHAM ER et al.: Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J. Biol. Chem. (2000) 275:22313-22323.
32. HOMEY B, ALENIUS H, MULLER A et al.: CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nat. Med. (2002) 8:157-165. This paper elegantly demonstrated where CCL27 and CCR10 were expressed in inflamed skin, showed bioactivity of CCL27 in animal models, and, along with [33], provided evidence that CCL27 was required for T cell homing to the skin during ongoing cutaneous inflammation.
33. REISS Y, PROUDFOOT AE, POWER CA, CAMPBELL JJ, BUTCHER EC: CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin. J. Exp. Med. (2001) 194:1541-1547. Using CCR4 null mice and anti-CCL27 neutralising neutrulising antibodies, this publication showed that CCR4 and CCR10 expression by CLA+ skin-homing T cells is used to direct these cells to the skin during inflammation.
34. HUDAK S, HAGEN M, LIU Y et al.: Immune surveillance and effector functions of CCR10+ skin homing T cells. J. Immunol. (2002) 169:1189-1196.
35. SOLER D, HUMPHREYS TL, SPINOLA SM, CAMPBELL JJ: CCR4 versus CCR10 in human cutaneous Th lymphocyte trafficking. Blood (2002) In press (online DOI 10.1182)
36. CAMPBELL JJ, HARALDSEN G, PAN J et al.: The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature (1999) 400:776-780.
37. SALLUSTO F, LENIG D, FORSTER R, LIPP M, LANZAVECCHIA A: Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature (1999) 401:708-712.
38. KUNKEL EJ, BUTCHER EC: Chemokines and the tissue-specific migration of lymphocytes. Immunity (2002) 16:1-4. Recent up-to-date review of chemokine receptors involved in tissue-specific migration.
39. GORTZ A, NIBBS RJ, MCLEAN P et al.: The chemokine ESkine/CCL27 displays novel modes of intracrine and paracrine function. J. Immunol. (2002) 169:1387-1394. This report localised the PESKY nuclear localisation signal to the carboxy terminus, also found in CCL27, and for the first time showed nuclear accumulation of chemokine after receptor-mediated internalisation from outside the cell. It also demonstrated that PESKY alters cell morphology and motility, possibly via transcriptional regulation.
40. DELRIEU I: The high molecular weight isoforms of basic fibroblast growth factor (FGF-2): an insight into an intracrine mechanism. FEBS Lett. (2000) 468:6-10.
41. NAKANO H, GUNN MD: Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation. J. Immunol. (2001) 166:361-369.
42. WALZ A, SCHMUTZ P, MUELLER C, SCHNYDER-CANDRIAN S: Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease J. Leukoc. Biol. (1997) 62:604-611.
43. NILSSON CL, MURPHY CM, EKMAN R: Isolation and characterization of proteins from human lymphocyte nuclei using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and post-source decay analysis. Rapid Commun. Mass Spectrom. (1997) 11:610-612.
44. JANS DA, HASSAN G: Nuclear targeting by growth factors, cytokines, and their receptors: a role in signaling? Bioessays (1998) 20:400-411.
45. CONSTANTIN G, MAJEED M, GIAGULLI C et al.: Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow. Immunity (2000) 13:759-769.
46. CINAMON G, SHINDER V, ALON R: Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines. Nat. Immunol. (2001) 2:515-522.
47. WILEY HE, GONZALEZ EB, MAKI W, WU MT, HWANG ST: Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma. J. Natl. Cancer Inst. (2001) 93:1638-1643.