Abrogation of the cell death response to oxidative stress by the c-Abl tyrosine kinase inhibitor STI571

Molecular Pharmacology

Volumn 63, Issue 2, 2003, Pages 276-282

  Kumar, Shailendra ^a   Mishra, Neerad ^b   Raina, Deepak ^a   Saxena, Satya ^b   Kufe, Donald ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; BCR ABL PROTEIN; HYDROGEN PEROXIDE; IMATINIB; LIPOCORTIN 5; PROTEIN; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL FRACTIONATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA CONTENT; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; MEMBRANE POTENTIAL; MOUSE; MYELOID LEUKEMIA; NECROSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; ENZYME INHIBITORS; MEMBRANE POTENTIALS; MICE; MITOCHONDRIA; OXIDATIVE STRESS; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-ABL; PYRIMIDINES;

EID: 0037309894     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.63.2.276     Document Type: Article

References (34)

1. Agami R, Blandino G, Oren M, and Shaul Y (1999) Interaction of c-Abl and p73α and their collaboration to induce apoptosis. Nature (Lond) 399:809-813.
2. Berlett S and Stadtman E (1997) Protein oxidation in aging, disease and oxidative stress. J Biol Chem 272:20313-20316.
3. Carroll M, Ohno-Jones S, Tamura S, Buchdunger E, Zimmermann J, Lydon NB, Gilliland DG, and Druker BJ (1997) CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL and TEL-PDGFR fusion proteins. Blood 90:4947-4952.
4. Croteau D and Bohr V (1997) Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells. J Biol Chem 272:25409-25412.
5. Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM, Capdeville R, and Talpaz M (2001) Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 344:1038-1042.
6. Druker BJ, Tamura S, Buchdunger E, Ohno S, Segal GM, Fanning S, Zimmermann J, and Lydon NB (1996) Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 2:561-566.
7. Gong J, Costanzo A, Yang H, Melino G, Kaelin JRW, Levrero M, and Wang JYJ (1999) The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature (Lond) 399:806-809.
8. Gorre ME, Mohammed M, Ellwood K, Hsu N, Paquette R, Rao PN, and Sawyers CL (2001) Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science (Wash DC) 293:876-880.
9. Jacobson MD, Weil M, and Raff MC (1996) Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death. J Biol Chem 133:1041-1051.
10. Johnson T, Yu Z, Ferrans V, Lowenstein R, and Finkel T (1996) Reactive oxygen species are downstream mediators of p53-dependent apoptosis. Proc Natl Acad Sci USA 93:11848-11852.
11. Kagan VE, Kuzmenko AI, Tyurina YY, Shvedova AA, Matsura T, and Yalowich JC (2001) Pro-oxidant and antioxidant mechanisms of etoposide in HL-60 cells: role of myeloperoxidase. Cancer Res 61:7777-7784.
12. Khanna KK and Jackson SP (2001) DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 27:247-254.
13. Kharbanda S, Ren R, Pandey P, Shafman TD, Feller SM, Weichselbaum RR, and Kufe DW (1995) Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents. Nature (Lond) 376:785-788.
14. Kumar S, Bharti A, Mishra N, Kharbanda S, Saxena S, and Kufe D (2001) Targeting of the c-Abl tyrosine kinase to mitochondria in the necrotic cell death response to oxidative stress. J Biol Chem 276:17281-17285.
15. LeBel C, Ischiropoulos H, and Bondy S (1992) Evaluation of the probe 2′-dichlorofluorescein as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol 5:227-231.
16. Li T, Chen A, Yu C, Mao Y, Wang H, and Liu L (1999) Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress. Genes Dev 13:1553-1560.
17. Majumder P, Bharti A, Sun X, Saxena S, and Kufe D (2001) Targeting of protein kinase Cδ to mitochondria in the oxidative stress response. Cell Growth Diff 12:465-470.
18. Manna SK, Zhang HJ, Yan T, Oberley LW, and Aggarwal BB (1998) Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1. J Biol Chem 273:13245-54.
19. Martin SJ and Green DR (1995) Protease activation during apoptosis: death by a thousand cuts? Cell 82:349-352.
20. Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L, and Pelicci PG (1999) The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature (Lond) 402:309-313.
21. Monks C, Freiberg B, Kupfer H, Sciaky N, and Kupfer A (1998) Three-dimensional segregation of supermolecular activation clusters in T cells. Nature (Lond) 395:82-86.
22. Polyak K, Xia Y, Zweier JL, Kinzler KW, and Vogelstein B (1997) A model for p53-induced apoptosis. Nature (Lond) 389:300-305.
23. Roederer M, Staal FJ, Raju PA, Ela SW, and Herzenberg LA (1990) Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine. Proc Natl Acad Sci USA 87:4884-4888.
24. Schindler T, Bornmann W, Pellicena P, Miller WT, Clarkson B, and Kuriyan J (2000) Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase. Science (Wash DC) 289:1938-1942.
25. Shi X, Leonard SS, Wang S, and Ding M (2000) Antioxidant properties of pyrrolidine dithiocarbamate and its protection against Cr(VI)-induced DNA strand breakage. Ann Clin Lab Sci 30:209-216.
26. Skorski T (2002) Oncogenic tyrosine kinases and the DNA-damage response. Nat Rev Cancer 2:351-360.
27. Staal FJ, Roederer M, and Herzenberg LA (1990) Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus. Proc Natl Acad Sci USA 87:9943-9947.
28. Sun X, Majumder P, Shioya H, Wu F, Kumar S, Weichselbaum R, Kharbanda S, and Kufe D (2000a) Activation of the cytoplasmic c-Abl tyrosine kinase by reactive oxygen species. J Biol Chem 275:17237-40.
29. Sun X, Wu F, Datta R, Kharbanda S, and Kufe D (2000b) Interaction between protein kinase C δ and the c-Abl tyrosine kinase in the cellular response to oxidative stress. J Biol Chem 275:7470-7473.
30. Yin Y, Terauchi Y, Solomon G, Aizawa S, Rangarajan P, Yazaki Y, Kadowaki T, and Barrett J (1998) Involvement of p85 in p53-dependent apoptotic response to oxidative stress. Nature (Lond) 391:707-710.
31. Yuan ZM, Huang Y, Ishiko T, Kharbanda S, Weichselbaum R, and Kufe D (1997) Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase. Proc Natl Acad Sci USA 94:1437-1440.
32. Yuan ZM, Huang Y, Whang Y, Sawyers C, Weichselbaum R, Kharbanda S, and Kufe D (1996) Role for the c-Abl tyrosine kinase in the growth arrest response to DNA damage. Nature (Lond) 382:272-274.
33. Yuan ZM, Shioya H, Ishiko T, Sun X, Huang Y, Lu H, Kharbanda S, Weichselbaum R, and Kufe D (1999) p73 is regulated by the c-Abl tyrosine kinase in the apoptotic response to DNA damage. Nature (Lond) 399:814-817.
34. Zimmermann J, Buchdunger E, Mett H, Meyer T, and Lyndon N (1997) Potent and selective inhibitors of the Abl-kinase phenylamino-pyrimidine (PAP) derivatives. Bioorg Med Chem Lett 7:187-192.