Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: Effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring

European Journal of Medicinal Chemistry

Volumn 38, Issue 2, 2003, Pages 157-168

  Balsamo, Aldo ^a   Coletta, Isabella ^b   Guglielmotti, Angelo ^b   Landolfi, Carla ^b   Mancini, Francesca ^b   Martinelli, Adriano ^a   Milanese, Claudio ^b   Minutolo, Filippo ^a   Nencetti, Susanna ^a   Orlandini, Elisabetta ^a   Pinza, Mario ^b   Rapposelli, Simona ^a   Rossello, Armando ^a  

^a UNIVERSITY OF PISA   (Italy)

^b Università Politecnica delle Marche ACRAF Gruppo Angelini   (Italy)

Author keywords

Antiinflammatory drug; Aryl substituted methyleneaminoxymethyl moiety; COX 2 inhibitor; Heteroaromatic COX 2 inhibitor

Indexed keywords

1 (4 AMINOSULFONYLPHENYL); 1 (4 METHYLSULFONYLPHENYL)PYRAZOLE; 3 (4 METHYLSULFONYLPHENYL); ALICYCLIC COMPOUND; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; FUNCTIONAL GROUP; HETEROCYCLIC COMPOUND; ISOENZYME; ISOXAZOLE DERIVATIVE; METHYL GROUP; OXIME DERIVATIVE; PYRAZOLE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ARYLATION; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; METHYLATION; PHARMACOPHORE; POLYMERIZATION; SUBSTITUTION REACTION;

EID: 0037293083     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(02)01448-4     Document Type: Article

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