Chemistry and pharmacokinetics of diarylthiophenes and terphenyls as selective COX-2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 24, 1996, Pages 2907-2912

  Pinto, Donald J P ^a   Copeland, Robert A ^a   Covington, Maryanne B ^a   Pitts, William J ^a   Batt, Douglas G ^a   Orwat, Michael J ^a   Lam, Gilbert N ^a   Joshi, Amita ^a   Chan, Yuk Charn ^a   Wang, Shuaige ^a   Trzaskos, James M ^a   Magolda, Ronald L ^a   Kornhauser, David M ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR; TERPHENYL DERIVATIVE; THIOPHENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DOG; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INTRAVENOUS DRUG ADMINISTRATION; MONKEY; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SHEEP; SPECIES DIFFERENCE;

EID: 0030591849     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(96)00513-6     Document Type: Article

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