Celecoxib antiinflammatory cyclooxygenase-2 inhibitor

Drugs of the Future

Volumn 22, Issue 7, 1997, Pages 711-714

  Graul, A ^a   Martel, A M ^a   Castaner J ^a  

^a PROUS SCIENCE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CELECOXIB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; UNCLASSIFIED DRUG;

ANALGESIA; ANTIINFLAMMATORY ACTIVITY; BLOOD LEVEL; DRUG EFFICACY; DRUG SAFETY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IN VITRO STUDY; NONHUMAN; ORAL DRUG ADMINISTRATION; OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; SHORT SURVEY;

EID: 0030798922     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1997.022.07.412128     Document Type: Short Survey

References (16)

1. Talley, J.J., Penning, T.D., Collins, R.W. et al. (G.D. Searle & Co.). Substd. pyrazolyl benzenesulfonamides for the treatment of inflammation. EP 731795, US 5521207, WO 9515316.
2. Zhi, B., Newaz, M., Talley, J.J., Bertenshaw, S. (G.D. Searle & Co.). Method of preparing 3-haloalkyl-1H-pyrazoles. WO 9637476.
3. Penning, T.D., Talley, J.J., Bertenshaw, S.R. et al. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: Identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide (SC-58635, celecoxib). J Med Chem 1997, 40: 1347-65.
4. 2: Key mediators of inflammation and pain. IBC 3rd Annu Conf Signal Transduct Ther. Novel Targets Ther Interv (Sept 16-17, San Diego) 1996.
5. Battistini, B., Botting, R., Bakhle, Y.S. COX-1 and COX-2: Toward the development of more selective NSAIDs. Drug News Perspect 1994, 7: 501-12.
6. Parnham, M.J. Inflammation: Mechanisms and therapeutics. Drug News Perspect 1996, 9: 631-9.
7. Lanza, F.L., Rack, M.F., Callison, D.A., Hubbard, R.C., Yu, S.S., Talwalker, S., Geis, G.S. A pilot endoscopic study of the gastroduodenal effects of SC-58635. a novel COX-2-selective inhibitor. Dig Dis Week (May 10-16, Washington DC) 1997, Abst 400.
8. Mehlisch, D.R., Hubbard, R.C., Isakson, P.C., Perkins, S., Weaver, M., Mills, S. A single-blind, placebo controlled comparison of the analgesic efficacy of a highly selective inhibitor of COX-2 (SC-58635) versus aspirin 650 mg in patients with post-surgical dental pain. 8th World Cong Pain (Aug 17-22, Vancouver) 1996, 288.
9. Mehlisch, D.R., Hubbard, R.C., Isakson, P., Karim, A., Weaver, M., Mills, S. Analgesic efficacy and plasma levels of a highly selective inhibitor of COX-2 (SC-58635; SC) in patients with post-surgical dental pain. Clin Pharmacol Ther 1997, 61(2): Abst PIII-2.
10. Hubbard, R.C., Mehlisch, D.R., Jasper, D.R., Nugent, M.J., Yu, S., Isakson, P.C. SC-58635, a highly selective inhibitor of COX-2, is an effective analgesic in an acute post-surgical pain model. J Invest Med 1996, 44(3): 293A.
11. Hubbard, R.C., Koepp, R.J., Yu, S., Talwalker, S., Geis, G.S., Wiesenhutter, C.W., Makarowski, W.S., Paulus, H.A. SC-58635 (celecoxib), a novel COX-2 selective inhibitor, is effective as a treatment for osteoarthritis (OA) in a short-term pilot study. Arthritis Rheum 1996, 39(9, Suppl.): Abst 1188.
12. Isakson, P.C., Anderson, G.D., Gregory, S.A. (G.D. Searle & Co.). Compsns. comprising a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor. WO 9641626.
13. 4 hydrolase inhibitor. WO 9641625.
14. 4 receptor antagonist for the treatment of inflammation. WO 9641645.
15. Searle announces agreement with Yamanouchi Pharmaceutical Co., Ltd., to co-develop and co-market novel anti-inflammatory drug. G.D. Searle & Co. Press Release 1996, April 18.
16. Yamanouchi Pharmaceutical Co., Ltd. Annual Report 1996.