Innate immune recognition by stimulatory immunoreceptors

Current Opinion in Immunology

Volumn 15, Issue 1, 2003, Pages 37-44

  Diefenbach, Andreas ^a   Raulet, David H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MARKER; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NATURAL KILLER CELL RECEPTOR NKG2D; PROTEIN; PROTEIN LY49H; TRIGGERING RECEPTOR PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; IMMUNOGLOBULIN RECEPTOR; LECTIN; LY 49 ANTIGEN; LY ANTIGEN; LY-49 ANTIGEN; MEMBRANE PROTEIN; NATURAL KILLER CELL ACTIVATING RECEPTORS;

ANTIGEN RECOGNITION; BONE MARROW CELL; CELL SPECIFICITY; CYTOMEGALOVIRUS INFECTION; HUMAN; IMMUNE SYSTEM; INFECTION RESISTANCE; LYMPHOCYTE SUBPOPULATION; MACROPHAGE; MULTIGENE FAMILY; NATURAL KILLER CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; T LYMPHOCYTE; ANIMAL; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; VIRUS;

ANIMALS; ANTIGENS, LY; IMMUNITY, NATURAL; KILLER CELLS, NATURAL; LECTINS, C-TYPE; LYMPHOCYTE SUBSETS; MEMBRANE GLYCOPROTEINS; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; VIRUSES;

EID: 0037290762     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(02)00007-9     Document Type: Review

References (54)

1. Diefenbach A., Raulet D.H. Strategies for target cell recognition by natural killer cells. Immunol. Rev. 181:2001;170-184.
2. R locus is identical to the Ly49h gene. Blockade of Ly49H in MCMV resistant mice rendered them susceptible to infection.
3. ••].
4. ••].
5. ••], this paper demonstrates that Ly49H binds to the MCMV encoded protein m157. The authors provide evidence that m157 activates NK cells via Ly49H and that m157 is structurally related to class I MHC molecules.
6. ••].
7. Bouchon A., Facchetti F., Weigand M.A., Colonna M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature. 410:2001;1103-1107 The authors demonstrate that TREM-1 is upregulated on myeloid cells after stimulation with bacteria and fungi, and synergizes with LPS in the production of pro-inflammatory cytokines (TNF-α and IL-1β). Blocking of TREM-1 prevents sepsis in three experimental sepsis models.
8. Raulet D.H., Vance R.E., McMahon C.W. Regulation of the natural killer cell receptor repertoire. Annu. Rev. Immunol. 19:2001;291-330.
9. Ljunggren H.G., Karre K. In search of the 'missing self': MHC molecules and NK cell recognition. Immunol. Today. 11:1990;237-244.
10. Moretta L., Bottino C., Vitale M., Pende D., Cantoni C., Mingari M., Biassoni R., Moretta A. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 19:2001;197-223.
11. Diefenbach A., Jamieson A.M., Liu S.D., Shastri N., Raulet D.H. Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat. Immunol. 1:2000;119-126.
12. + T cells. The authors also demonstrate a role for NKG2D in NK killing of tumor target cells.
13. Bauer S., Groh V., Wu J., Steinle A., Phillips J.H., Lanier L.L., Spies T. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science. 285:1999;727-729.
14. Pende D., Cantoni C., Rivera P., Vitale M., Castriconi R., Marcenaro S., Nanni M., Biassoni R., Bottino C., Moretta A., Moretta L. Role of NKG2D in tumor cell lysis mediated by human NK cells: cooperation with natural cytotoxicity receptors and capability of recognizing tumors of nonepithelial origin. Eur. J. Immunol. 31:2001;1076-1086.
15. Roberts A.I., Lee L., Schwarz E., Groh V., Spies T., Ebert E.C., Jabri B. NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment. J. Immunol. 167:2001;5527-5530.
16. Diefenbach A., Raulet D.H. Natural killer cells: stress out, turn on, tune in. Curr. Biol. 9:1999;R851-R853.
17. Groh V., Steinle A., Bauer S., Spies T. Recognition of stress-induced MHC molecules by intestinal epithelial γδ T cells. Science. 279:1998;1737-1740.
18. Wu J., Groh V., Spies T. T cell antigen receptor engagement and specificity in the recognition of stress-inducible MHC class I-related chains by human epithelial γδ T cells. J. Immunol. 169:2002;1236-1240 Using a transfection system, the authors demonstrate that MICA binds to both the γδ receptor and NKG2D.
19. Groh V., Rhinehart R., Secrist H., Bauer S., Grabstein K.H., Spies T. Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB. Proc. Natl. Acad. Sci. U.S.A. 96:1999;6879-6884.
20. + T cells.
21. Tieng V., Le Bouguenec C., du Merle L., Bertheau P., Desreumaux P., Janin A., Charron D., Toubert A. Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA. Proc. Natl. Acad. Sci. U.S.A. 99:2002;2977-2982.
22. Groh V., Bahram S., Bauer S., Herman A., Beauchamp M., Spies T. Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc. Natl. Acad. Sci. U.S.A. 93:1996;12445-12450.
23. Bahram S., Bresnahan M., Geraghty D.E., Spies T. A second lineage of mammalian major histocompatibility complex class I genes. Proc. Natl. Acad. Sci. U.S.A. 91:1994;6259-6263.
24. Cerwenka A., Bakker A.B.H., McClanahan T., Wagner J., Wu J., Phillips J.H., Lanier L.L. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity. 12:2000;721-727.
25. Nomura M., Zou Z., Joh T., Takihara Y., Matsuda Y., Shimada K. Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain. J. Biochem. (Tokyo). 120:1996;987-995.
26. Zou Z., Nomura M., Takihara Y., Yasunaga T., Shimada K. Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: a novel cDNA family encodes cell surface proteins sharing partial homology with MHC class I molecules. J. Biochem. (Tokyo). 119:1996;319-328.
27. Girardi M., Oppenheim D.E., Steele C.R., Lewis J.M., Glusac E., Filler R., Hobby P., Sutton B., Tigelaar R.E., Hayday A.C. Regulation of cutaneous malignancy by γδ T cells. Science. 294:2001;605-609 This paper provides evidence that carcinogen-induced skin tumors upregulate ligands for NKG2D.
28. Carayannopoulos L.N., Naidenko O.V., Kinder J., Ho E.L., Fremont D.H., Yokoyama W.M. Ligands for murine NKG2D display heterogeneous binding behavior. Eur. J. Immunol. 32:2002;597-605.
29. Malarkannan S., Shih P.P., Eden P.A., Horng T., Zuberi A.R., Christianson G., Roopenian D., Shastri N. The molecular and functional characterization of a dominant minor H antigen, H60. J. Immunol. 161:1998;3501-3509.
30. + T cells. Mice that had rejected ligand expressing tumor cells were immune to the rechallenge with the wild-type tumor, suggesting that this approach may be applicable as an anti-tumor vaccine.
31. Cosman D., Müllberg J., Sutherland C.L., Chin W., Armitage R., Fanslow W., Kubin M., Chalupny N.J. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity. 14:2001;123-133 The authors describe the identification of a second family of human ligands for the NKG2D receptor, which are related to mouse Rae1 and H60. Interestingly, these proteins also interact with UL16 encoded by HCMV, suggesting that this virus may have developed an immune evasion strategy to avoid recognition via NKG2D.
32. Onda H., Ohkubo S., Shintani Y., Ogi K., Kikuchi K., Tanaka H., Yamamoto K., Tsuji I., Ishibashi Y., Yamada T.et al. A novel secreted tumor antigen with a glycosylphosphatidylinositol-anchored structure ubiquitously expressed in human cancers. Biochem. Biophys. Res. Commun. 285:2001;235-243.
33. Radosavljevic M., Cuillerier B., Wilson M.J., Clement O., Wicker S., Gilfillan S., Beck S., Trowsdale J., Bahram S. A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. Genomics. 79:2002;114-123.
34. Kubin M., Cassiano L., Chalupny J., Chin W., Cosman D., Fanslow W., Mullberg J., Rousseau A.M., Ulrich D., Armitage R. ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells. Eur. J. Immunol. 31:2001;1428-1437.
35. Sutherland C.L., Chalupny N.J., Schooley K., VandenBos T., Kubin M., Cosman D. UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells. J. Immunol. 168:2002;671-679.
36. ••].
37. + T cells strictly depends on perforin but not IFN-γ.
38. Brennan J., Mager D., Jefferies W., Takei F. Expression of different members of the Ly-49 gene family defines distinct natural killer cell subsets and cell adhesion properties. J. Exp. Med. 180:1994;2287-2295.
39. Smith K.M., Wu J., Bakker A.B., Phillips J.H., Lanier L.L. Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors. J. Immunol. 161:1998;7-10.
40. Smith H.R.C., Chuang H.H., Wang L.L., Salcedo M., Heusel J.W., Yokoyama W.M. Nonstochastic coexpression of activation receptors on murine natural killer cells. J. Exp. Med. 191:2000;1341-1354.
41. Dokun A.O., Kim S., Smith H.R., Kang H.S., Chu D.T., Yokoyama W.M. Specific and nonspecific NK cell activation during virus infection. Nat. Immunol. 2:2001;951-956.
42. Lanier L.L., Bakker A.B. The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function. Immunol. Today. 21:2000;611-614.
43. Chung D.H., Seaman W.E., Daws M.R. Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17. Eur. J. Immunol. 32:2002;59-66.
44. Bouchon A., Dietrich J., Colonna M. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J. Immunol. 164:2000;4991-4995.
45. Bouchon A., Hernandez-Munain C., Cella M., Colonna M. A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells. J. Exp. Med. 194:2001;1111-1122.
46. Daws M.R., Lanier L.L., Seaman W.E., Ryan J.C. Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. Eur. J. Immunol. 31:2001;783-791.
47. Vitale M., Bottino C., Sivori S., Sanseverino L., Castraconi R., Marcenaro E., Augugliaro R., Moretta L., Moretta A. NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis. J. Exp. Med. 187:1998;2065-2072.
48. Cantoni C., Bottino C., Vitale M., Pessino A., Augugliaro R., Malaspina A., Parolini S., Moretta L., Moretta A., Biassoni R. NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily. J. Exp. Med. 189:1999;787-796.
49. Mandelboim O., Lieberman N., Lev M., Lada P., Arnon T.I., Bushkin Y., Davis D.M., Strominger J.L., Yewdell J.W., Porgador A. Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells. Nature. 409:2001;1055-1060.
50. Medzhitov R., Janeway C.A. Jr. Decoding the patterns of self and nonself by the innate immune system. Science. 296:2002;298-300.
51. Schnare M., Barton G.M., Holt A.C., Takeda K., Akira S., Medzhitov R. Toll-like receptors control activation of adaptive immune responses. Nat. Immunol. 2:2001;947-950 Using MyD88-deficient mice, the authors provide evidence that TLRs are involved in the priming of potent adaptive immune responses.
52. Diefenbach A, Tomasello E, Lucas M, Jamieson AM, Hsia JK, Vivier E, Raulet DH: Selective associations with signaling molecules determines stimulatory versus costimulatory activity of NKG2D. Nat Immunology 2002, 3: in press.
53. Gilfillan S, Ho EL, Cella M, Yokoyama WM, Colona M: NKG2D recruits two distinct adapters to trigger natural killer cell activation and costimulation. Nat Immunology 2002, 3: in press.
54. + T cells that have downregulated NKG2D are no longer co-stimulated by tumor cells expressing NKG2D ligands. These data provide the first evidence for a mechanism employed by tumor cells to evade immune recognition by the NKG2D receptor.