Limited penetration of lopinavir into seminal plasma of HIV-1-infected men [5]

AIDS

Volumn 16, Issue 12, 2002, Pages 1698-1700

  Sankatsing, Sanjay U C ^a,b   Droste, Jackie ^c   Burger, David ^c   Van Praag, Rieneke M E ^a,b   Jurriaans, Suzanne ^a   Lange, Joep M A ^a,b   Prins, Jan M ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b International Antiviral Therapy Evaluation Center (IATEC)   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; AMPRENAVIR; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; EFAVIRENZ; INDINAVIR; LAMIVUDINE; LOPINAVIR; NELFINAVIR; NEVIRAPINE; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR; STAVUDINE; ZIDOVUDINE;

CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; DRUG BLOOD LEVEL; DRUG INDICATION; DRUG PENETRATION; FOLLOW UP; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LETTER; MALE; PRIORITY JOURNAL; SEMEN ANALYSIS; SEMINAL PLASMA; SIDE EFFECT; STRAIN DIFFERENCE; TREATMENT OUTCOME;

HIV INFECTIONS; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; MALE; PYRIMIDINONES; SEMEN;

EID: 0037119029     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200208160-00023     Document Type: Letter

References (14)

1. Potent antiretroviral treatment of HIV-infection results in suppression of the seminal shedding of HIV. The Swiss HIV Cohort Study
2. Resistance of HIV-1 to antiretroviral agents in blood and seminal plasma: Implications for transmission
3. The effects of protease inhibitor therapy on human immunodeficiency virus type 1 levels in semen (AIDS clinical trials group protocol 850)
4. Antiretroviral-drug concentrations in semen: Implications for sexual transmission of human immunodeficiency virus type 1
5. Poor penetration of the male genital tract by HIV-1 protease inhibitors
6. Pharmacokinetic profiles of nevirapine and indinavir in various fractions of seminal plasma
7. Penetration of efavirenz into the male genital tract: Drug concentrations and antiviral activity in semen and blood of HIV-1-infected men
8. Penetration of the nucleoside analogue abacavir into the genital tract of men infected with human immunodeficiency virus type 1
9. Concurrent zidovudine levels in semen and serum determined by radioimmunoassay in patients with AIDS or AIDS-related complex
10. Nucleoside analogues achieve high concentrations in seminal plasma: Relationship between drug concentration and virus burden
11. Concentrations of nevirapine, lamivudine and stavudine in semen of HIV-1-infected men
12. Enhanced penetration of indinavir in cerebrospinal fluid and semen after the addition of low-dose ritonavir
13. Simultaneous determination of the HIV-protease inhibitors indinavir, nelfinavir, saquinavir and ritonavir in human plasma by reversed-phase high-performance liquid chromatography
14. Multiple drug resistance mutations in human immunodeficiency virus in semen but not blood of a man on antiretroviral therapy