Concentrations of nevirapine, lamivudine and stavudine in semen of HIV-1-infected men

AIDS

Volumn 14, Issue 13, 2000, Pages 1979-1984

  Taylor, Stephen ^a,b,d   Van Heeswijk, Rolf P G ^c   Hoetelmans, Richard M W ^c   Workman, Judith ^a   Drake, Susan M ^b   White, David J ^b   Pillay, Deenan ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b BIRMINGHAM HEARTLANDS HOSPITAL   (United Kingdom)

^c SLOTERVAART HOSPITAL   (Netherlands)

^d UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

Author keywords

HIV 1; Lamivudine; Nevirapine; Pharmacokinetics; Semen; Stavudine

Indexed keywords

LAMIVUDINE; NEVIRAPINE; STAVUDINE;

ADULT; ARTICLE; CLINICAL ARTICLE; DRUG BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; PRIORITY JOURNAL; SEMINAL PLASMA; SPERM; VIRUS LOAD;

ADULT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; HIV INFECTIONS; HIV-1; HUMANS; LAMIVUDINE; MALE; NEVIRAPINE; PROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE INHIBITORS; SEMEN; STAVUDINE;

EID: 0034622962     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200009080-00014     Document Type: Article

References (23)

1. High viral load in semen of human immunodeficiency virus type 1-infected men at all stages of disease and its reduction by therapy with protease and nonnucleoside reverse transcriptase inhibitors
2. Effect of antiviral treatment on the shedding of HIV-1 in semen
3. Poor reduction of HIV-1 RNA titres in nucleoside reverse transcriptase inhibitor experienced patients treated with indinavir combination therapy
4. Detection and quantification of HIV-1 in semen. Identification of a subpopulation of men at high potential risk of viral sexual transmission
5. Asymptomatic urethritis and detection of HIV-1 RNA in seminal plasma
6. Multidrug resistant HIV-1 in semen: Reduction by treatment of concurrent gonorrhoea
7. Detection of drug resistance mutations in the human immunodeficiency virus type 1 (HIV-1) pol gene: Differences in semen and blood HIV-1 RNA and proviral DNA
8. Analysis of human immunodeficiency virus in semen: Indications of a genetically distinct virus reservoir
9. Resistance of HIV-1 to antiretroviral agents in blood and seminal plasma: Implications for transmission
10. Genoypic differences between plasma and seminal fluid HIV RNA in reverse transcriptase inhibitor experienced patients
11. Antiretroviral-drug concentrations in semen. Implications for sexual transmission of human immunodeficiency virus type 1
12. High dose nevirapine. Safety, pharmacokinetics, and antiviral effect in patients with human immunodeficiency virus infection
13. High exposure to nevirapine is associated with a higher initial HIV-1 clearance rate, a higher likelihood to reach undetectability and prolonged suppression of HIV-1 replication
14. Rapid determination of nevirapine in human plasma by ion-pair reversed phase high-performance liquid chromatography with ultra-violet detection
15. Quantitative determination of (-)-2'-deoxy-3'-thiacytidine (lamivudine) in human plasma, saliva and cerebrospinal fluid by high-performance liquid chromatography with ultraviolet detection
16. Poor penetration of the male genital tract by HIV-1 protease inhibitors
17. Cerebrospinal-fluid HIV-1 RNA and drug concentrations after treatment with lamivudine plus zidovudine or stavudine
18. MRP4 A previously unidentified factor in resistance to nucleoside-based antiviral drugs
19. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV protease inhibitors
20. The effect of zidovudine dose on the formation of intracellular phosphorylated metabolites
21. Nucleoside analogues achieve high concentrations in seminal plasma: Relationship between drug concentration and virus burden
22. The pharmacokinetics of lamivudine phosphorylation in peripheral blood mononuclear cells from patients infected with HIV-1
23. Ritonavir (RTV)/ saquinavir (SQV) versus RTV/SQV/D4T in cerebrospinal fluid (CSF): Drug concentrations and the effect of these regimens on CSF HIV-RNA levels