Structure-based design of novel anti-cancer agents targeting Aurora kinases

Current Medicinal Chemistry - Anti-Cancer Agents

Volumn 3, Issue 1, 2003, Pages 25-34

  Mahadevan, Daruka ^a   Bearss, David J ^a   Vankayalapati, Hariprasad ^a,b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; ADENOSINE TRIPHOSPHATE DERIVATIVE; ANTINEOPLASTIC AGENT; AURORA KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN DEPENDENT KINASE; DYNEIN ADENOSINE TRIPHOSPHATASE; HISTONE; KINESIN; MALEIMIDE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 1; N (2 METHYLAMINOETHYL) 5 ISOQUINOLINESULFONAMIDE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; QUINAZOLINE DERIVATIVE; SERINE; STAUROSPORINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; BINDING AFFINITY; BREAST CANCER; CHROMOSOME SEGREGATION; COLORECTAL CANCER; CYTOKINESIS; DRUG DESIGN; DRUG SPECIFICITY; DRUG TARGETING; ENZYME ASSAY; GENE OVEREXPRESSION; HUMAN; IN VITRO STUDY; NONHUMAN; ONCOGENE; OVARY CANCER; PANCREAS TUMOR; PROSTATE CANCER; PROTEIN FAMILY; PROTEIN FUNCTION; REVIEW; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037242478     PISSN: 15680118     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568011033353524     Document Type: Review

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