Neuropeptides as autocrine growth factors in cancer cells

Current Pharmaceutical Design

Volumn 9, Issue 6, 2003, Pages 495-509

  Moody, Terry W ^a   Chan, Daniel ^b   Fahrenkurg, Jan ^c   Jensen, Robert T ^d  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF COLORADO CANCER CENTER   (United States)

^c BISPEBJERG HOSPITAL   (Denmark)

^d NONE

Author keywords

Bombesin; Lung cancer; Neurotensin; Somatostatin; Vasoactive intestinal peptide

Indexed keywords

2 [[1 (7 CHLORO 4 QUINOLINYL) 5 (2,6 DIMETHOXYPHENYL) 3 PYRAZOLYL]CARBONYLAMINO] 2 ADAMANTANECARBOXYLIC ACID; ANTINEOPLASTIC AGENT; BOMBESIN; BOMBESIN ANTAGONIST; BOMBESIN DERIVATIVE; BOMBESIN RECEPTOR; BOMBESIN[4 TYROSINE]; CANCER GROWTH FACTOR; CYCLIC AMP; GASTRIN RELEASING PEPTIDE; HYBRID PROTEIN; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE 27; MITOGEN ACTIVATED PROTEIN KINASE; NEUROMEDIN B; NEUROPEPTIDE; NEUROPEPTIDE RECEPTOR; NEUROTENSIN; NEUROTENSIN RECEPTOR ANTAGONIST; OCTREOTIDE; RC 3095; SECRETIN; SOMATOSTATIN; SOMATOSTATIN DERIVATIVE; SUBSTANCE P; SUBSTANCE P [1 DEXTRO ARGININE 2 DEXTRO PROLINE 7,9 DEXTRO TRYPTOPHAN 11 LEUCINE]; SUBSTANCE P ANTAGONIST; UNINDEXED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE ANTAGONIST; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR;

ANTINEOPLASTIC ACTIVITY; AUTOCRINE EFFECT; BREAST CANCER; CANCER GROWTH; CELL SURFACE; COLON CANCER; DRUG CYTOTOXICITY; DRUG METABOLISM; ENZYME ACTIVATION; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; IMMUNOREACTIVITY; ISOTOPE LABELING; LUNG SMALL CELL CANCER; MOUSE; NEUROENDOCRINE TUMOR; NONHUMAN; ONCOGENE; PANCREAS CANCER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BINDING; PROTEIN FUNCTION; RAT; RECEPTOR DENSITY; REVIEW;

AUTOCRINE COMMUNICATION; CARCINOMA, NEUROENDOCRINE; CARCINOMA, SMALL CELL; GROWTH SUBSTANCES; HUMANS; LUNG NEOPLASMS; NEUROPEPTIDES; RECEPTORS, NEUROPEPTIDE; TUMOR CELLS, CULTURED;

EID: 0037239215     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/1381612033391621     Document Type: Review

References (189)

1. Crawley, J.N. Trends Pharmacol. Sci. 1991, 12, 232.
2. Moody, T.W., Pert, C.B., Gazdar, A.F., Carney, D.N. and Minna, J.D. Science 1981, 214, 1246.
3. Wood, S., Wood, J., Ghatei, M., Lee, U., O'Shaghnessy, D. and Bloom, S.R. J. Clin. Endocrin. 1981, 53, 1310.
4. Moody, T.W., Carney, D.N., Korman, L.Y., Gazdar, A.F. and Minna, J.D. Life Sci. 1985, 36, 1727.
5. Korman, L.Y., Carney, D.N., Citron, M.L. and Moody, T.W. Cancer Res. 1986 46, 1214.
6. Moody, T.W., Carney, D.N., Cuttitta, F., Quattrochi, K. and Minna, J.D. Life Sci. 1985, 37, 105.
7. Trepel, J.B., Moyer, J.D., Cuttitta, F. Biochem. Biophys.Res. Commun. 1988, 156, 1383.
8. Moody, T.W., Murphy, A., Mahmoud, S. and Fiskum, G. Biochem. Biophys. Res. Commun. 1987, 147, 189.
9. Koh, S.-W.M., Leyton, J. and Moody, T.W. Peptides 1999, 20, 121. 1999.
10. Weber, H.C., Walters, J., Leyton, J., Casibang, M., Purdom, S., Jensen, R.T., Ellis, C., Clark, G. and Moody, T.W. Eur. J. Pharm. 2001, 412, 13.
11. Draoui, M., Chung, P., Park, M., Birrer, M., Jakowlew, S. and Moody, T.W. Peptides 1995, 16, 289.
12. Whitmarsh, A.J. and Davies, R.J. J. Mol. Medicine 1996, 74, 589.
13. Carney, D.N., Cuttitta, F., Moody, T.W. and Minna, J.D. Cancer Res. 1987, 47, 821.
14. Davis, T.P., Burgess, H.S., Crowell, S., Moody, T.W., Culling-Berglund, A. and Liu, R.H. Eur. J. Pharmacol. 1989, 161, 283.
15. Reubi, J.C. J. Nuc. Med. 1995, 36, 1825-1835.
16. Krenning, E.P., Kwekkeboom, D.J., Bakker, W.H., Breeman, W.A., Kooij, P.P., Oei, H.Y., van Hagen, M., Postema, P.T., de Jong, M., Reubi, J.C. Visser, T.J., Reijis, A.E., Hofland, L.J., Koper, J.W. and Lamberts, S.W.J. Eur. J. Nucl. Med 1993, 8, 716.
17. De Jong, M. Valkema, R., Jamar, F., Kvols, L.K., Kwekkeboom, D.J., Breeman, W.A., Bakker, W.H., Smith, C., Pauwels, S. and Krenning, E.P. Semin. Nucl. Med 2002, 32, 133.
18. Virgolini, I., Raderer, M., Kuraran, A., Angelberger, P., Banyai, S., Yang, Q., Li, S., Banyai, M., Pidlich, J., Niederle, B., Scheithauer, W. and Valent, P. N. Engl. J. Med. 1994, 331, 1116.
19. Reubi, J.C. Ann. N.Y. Acad Sci. 2000, 921, 1.
20. Mahmoud, S., Staley, J., Taylor, J., Bogden, A., Moreau, J.P., Coy, D., Avis, I., Cuttitta, F., Mulshine, J. and Moody, T.W. Cancer Res. 1991, 51, 1798.
21. Moody, T.W., Zia, F., Draoui, M., Brenneman, D.E., Fridkin, M., Davidson, A. and Gozes, I. Proc. Natl. Acad. Sci. USA, 1993, 90, 4345.
22. Moody, T.W., Leyton, J., Chan, D., Brenneman, D.C., Fridkin, M., Gelber, E., Levy, A. and Gozes, I. Breast Cancer Res. and Treatment, 1991, 68, 2172.
23. Falconieri, E.G., Severini, C., Erspamer, V., Melchiorri, P., Delle Favre, G. and Nakajima, T. Regul. Pept. 1988, 21, 1.
24. Minamino, N., Kangawa, K., Matsuo, H. Biochem. Biophys. Res. Commun. 1983, 114, 541.
25. McDonald, T.J., Jornvall, J., Nilsson, G., Vagne, M., Ghatei, M., Bloom, S.R. and Mutt, V. Biochem. Biophys. Res. Commun. 1979, 90, 227.
26. Spindel, E.R., Giladi, E., Brehm, J., Goodman, R.H. and Segerson, T.P. Mol. Endocrinol. 1990, 4, 1956-63.
27. Battey, J.F., Way, J., Corjay, M.H., Kusano, K., Perkins, R., Wu, J.M. Flattery, T., Mann, E. and Feldman, R.I. Proc. Natl. Acad. Sci. 1991, 88, 395.
28. Wada, E., Way, J., Shapira, H., Kusano, K., Lebacq-Verheyden, A.M., Coy, D., Jensen, R. and Battey, J. Neuron 1991, 6, 421.
29. Carney, D.N., Gazdar, A.F., Bepler, G., Guccion, J.G., Marangos, P.J., Moody, T.W., Zweig, M.H. and Minna, J.D. Cancer Res. 1985, 45, 2913.
30. Moody, T.W., Bertness, V. and Carney, D.N. Peptides 1993, 4, 683.
31. Cuttitta, F., Carney, D.N., Mulshine, J., Moody, T.W., Fedorko, J., Fischler, A. and Minna, J.D. Nature 1985, 316, 823.
32. Kelly, M.J., Linnoila, R.I., Avis, I.L., Georgiadis, M.S., Cuttitta, F., Mulshine, J.L. Chest 1997, 112, 256.
33. Jensen, R.T., Jones, S.W., Folkers, K. and Gardner, J.D. Nature 1984, 309, 61.
34. Jensen, R.T, and Coy, D.H. Trends Pharmacol. Sci. 1991, 1, 13.
35. Langdon, S., Sethi, T., Ritchie, A., Muir, M., Smyth, J. and Rozengurt, E. Cancer Res. 1992, 52, 4554.
36. Bepler, G., Zayner, H., Mahmoud, S.M., Fiskum, G., Palaszynski, E., Rotsch, M., Willey, J., Koros, A., Cuttitta, F., and Moody, T.W. Peptides 1988, 9, 1367.
37. Bunnett, N.W., Kobayashi, R., Orloff, M.S. Reeve, J.R., Turner, A.J. and Walsh, J.R. Peptides 1985, 6, 277.
38. Bunn, P.A., Dienhart, D.G., Chan, D. Check, T.T., Sagawa, M., Jewett, P.B. and Braunschweiger, E. Proc. Natl. Acad. Sci. USA, 1990, 87, 2162.
39. Jones, D.A., Cummings, J., Langdon, S.O. Maclellan, A.J., Hggins, T., Rozengurt, E. and Smyth, J.F. Br. J. Cancer 1996, 73, 715.
40. Reeve J.G. and Bleehen N.M. Biochem. Biophys. Res. Commun. 1994, 199, 1313.
41. Staley, J., Coy, D.H., Taylor, J.E., Kim, S. and Moody, T.W. Peptides 1991, 12, 145.
42. Coy, D.H., Heinz-Erian, P., Jiang, N.Y., Sasaki, Y., Taylor, J., Moreau, J.P., Wolfrey, W.T., Gardner, J.D. and Jensen, R.T. J. Biol. Chem. 1988, 263, 5056.
43. Moody, T.W., Zia, F., Venugopal, R., Patierno, S., LeBan, J. and McDermod, J. Life Sci. 1995, 56, 523.
44. Moody, T.W., Treston, A., Moody, E., Jakowlew, S. and Moody, T.W. Neuropeptides 2000, 34, 108.
45. Pinski, J., Halmos, G., Yano, T. Int. J. Cancer 1994, 57, 574
46. Radulovic, S., Miller, G., Schally, A.V. Cancer Res. 1991, 51, 6006.
47. Ashwood, V., Brownhil, V., Higginbottom, M., Horwell, D.C., Huhes, J., Lewthwaite, R.A., McKnight, A.T., Pinnock, R.D., Pritchard, M.C., Suman-Chauhan, N., Webb, C. and Williams, S.C. Bioorg. Med. Chem. Lett. 1998 8, 2589.
48. Eden, J.M., Hall, M.D., Higginbottom, M., Horwell, D.C., Howson, W., Hughes, J., Jordan, R.E., Lewthwaite, R.A., Martin, K., McKnight, A.T., O'Tolle, C., Pinnock, R.D., Pritchard, M.C., Suman-Chauhan, N. and Williams, S.C. Med. Chem. Lett. 1996, 6, 2617.
49. Moody, T.W., Jensen, R. and Leyton, J. Eur. J. Pharm. 2000, 409, 133.
50. Cardona, C., Rabbitts, P.H., Spindel, E.R., Ghatei, M.A., Bleehen, N.M. Cancer Res. 1991, 51, 5205.
51. Moody, T.W., Staley, J., Zia, F., Coy, D.H. and Jensen, R.T. J. Pharm. Exp. Ther. 1992, 263, 311.
52. DeMichele, M.A., Davis. A.L., Hunt, J.D., Landreneau, R.J. and Siegfried, J.M. J. Respir. Cell Mol. Biol. 1994, 11, 66.
53. Grady, E.F., Slice, L.W., Brant, W.O., Walsh, J.H., Payan, D.G. and Bunnett, N.W. J. Biol. Chem. 1995, 270, 4603.
54. Bunnett, N.W., Turner, A.J. and Debas, H.T. Q. J. Exp. Physiol. 1989, 74, 727.
55. Nagy, A., Armatic, P., Cai, R.Z., Szepeshazi, K., Halmos, G. and Schally, A.V. Proc. Natl. Acad. Sci. USA 1997, 94, 652.
56. Wanderspek, J.C., Sutherland, J.A., Zeng, H., Battey, J.F., Jensen, R.T. and Murphy, J.R. Cancer Res. 1997, 57, 290.
57. Guger, M. and J.C. Reubi. Am. J. Pathol. 1999, 155, 2067.
58. Maarkwalder, R. and Reubi, J.C. Cancer Res. 1999, 59, 1152.
59. Chave, H.S., Gough, A.C., Palmer, K., Preston, S.R. and Primrose, J.N. Br. J. Cancer 2000, 82, 124.
60. Carrol, R.E., Matkowshy, K.A., Chakrabarti, S., McDonald, T.J. and Benya, R.V. Am. J. Physiol. 1999, 276, G655.
61. Jensen, J.A., Carroll, R.E. and Benya, R.V. Peptides 2001, 22, 689
62. Pansky, A., DeWeerth, A., Fasler-Kan, E., Boulay, J.L., Schlz, M., Ketterer, S. J. Am. Soc. Nephrol. 2000, 11, 1409.
63. Lango, M.N., Dyer, K.F., Lui, V.W.Y., Gooding, W.E., Gubish, C., Siegfried, J.M. and Gandis, J.R. JNCI 2002, 94, 375.
64. Sun, B., Schally, A.v. and Halmos, G. Regul. Pept. 2000, 90, 77.
65. Sharif, T.R., Luo, W., Sharif, M. Mol. Cell Endocrinol. 1997, 130, 119.
66. Fleischmann, A., Laderach, U., Friess, H., Buechler, M. and Reubi, J.C. Lab. Invest. 2000, 80, 1807.
67. Mantey, A.S., Weber, H.C., Sainz, E., Akeson, M., Ryan, R.R., Pradhan, T.K., Searles, R.P., Spindel, E.R., Battey, J.F., Coy, D.H. and Jensen, R.T. J. Biol. Chem. 1977, 272, 26062.
68. Pradhan, T.K., Katsuno, T., Tayor, J.E., Kim, S,H., Ryan, R.R., Mantey, S.A., Donohue, P.J., Weber, H.C., Sainz, E., Battey, J.F., Coy, D.H. and Jensen, R.T. Eur. J. Pharmacol. 1998, 343, 275.
69. Reubi, J.C., Wenger, S., Schmuckli-Maurer, J., Schaer, J.C. and Gugger, M. Clin. Cancer Res. 2002, 4, 1139.
70. Safavy, A., Khazael, M.B., Qin, H., Buchsbaum, D.J. Cancer 1997, 80, 2354.
71. Karra, S.R., Schibli, R., Gali, H., Katti, K.V., Hoffman, T.J., Higginbotham, C., Sieckman, G.L. and Volkert, W.A. Bioconjug. Chem. 1999, 10, 254.
72. Van de Wiele, C., Dumont,, R., Dierckx, R.A., Peers, S.H., Thornback, J.R., Slegers, G. and Thierens, H. J. Nuc. Med. 2001, 42, 1722.
73. Said, S.I. and Mutt, V. Science 1970, 69, 1217.
74. Arimura, A. Reg. Peptides 1992, 37, 287.
75. Ishihara, T., Shigemoto, R., Mori, K., Takahashi, K. and Nagata, S. Neuron 1992, 8, 811.
76. Lutz, E.M., Sheward, W.J. West, K.M., Morrow, J..A. and Harmar, A.J. FEBS Lett. 1993, 334, 3.
77. Pisegna, J. and Wank, S.A. Proc. Natl. Acad. Sci. USA 1993, 90, 6345.
78. Spengler, D., Waeber, C., Pantaloni, C., Holsboe, F., Bockaert, J., Seeberg, P. and Journot, L. Nature 1993, 365, 170
79. Nicole, P., Lins, L., Rouyer-Fessard, C., Drouot, C, Fulcrand, P., Thomas, A. Couvineau, A., Martinez, J., Brasseur, R. and LaBurthe, M. J. Biol. Chem. 2000, 275, 24003.
80. Bodanszky, M., Amsterdam, Elsevier/North-Holland Biomedical Press. 1979, 15.
81. Igarachi, J., Ito, T., Hou, W., Mantey, S.A., Pradhan, T.K., Ulrich, C.D., Hocart, S.J., Coy, D.H., and Jensen, R.T. J. Pharmacol. Exp. Ther. 2002, 301, 37.
82. Christophe, J., Svoboda, M., Waelbroeck, M., Winand, J. and Robberecht, P. Ann. N.Y. Acad. Sci. 1988, 527, 238.
83. Lee, M., Jensen, R.T., Bepler, G., Korman, L.Y. and Moody, T.W. Peptides 1990, 11, 1205.
84. Shaffer, M.M., Carney, D.N., Korman, L.Y., Lebovic, G.L. and Moody, T.W. Peptides 1987, 8, 1101
85. Draoui, M., Hida, T., Jakowlew, S., Birrer, M., Zia, F. and Moody, T.W. Life Sci. 1996, 59, 307.
86. Casibang, M., Purdom, S., Zia, F., Jakowlew, S., Neckers, L. Ben-Av, P., Hla, T., You, L., Jablons, D. and Moody, T.W. Lung Cancer 2001, 31, 203.
87. Moody, T.W., Leyton, J., Coelho, T., Knight, M., Takahashi, K., Koh, M., Fridkin, M. and Gozes, I. Life Sci. 1997, 17, 1657.
88. Zia, H., Hida, T., Jakowlew, S., Birrer, M., Gozes, Y., Reubi, J.C., Fridkin, M., Gozes, I. and Moody, T.W. Cancer Res. 1996, 56, 3486.
89. Gourlet, P., Vandermeers, A., Vertongen, P., Rathe, J., DeNeef, P., Cnddle, J., Waelbroeck, M. and Robberecht, P., Peptides 1997, 18, 1539.
90. Bolin, D.R., Michelewsky, J., Wasserman, M.A. and O'Donnell, M. Biopolymers 1995, 37, 57.
91. Fahrenkrug, J., Biomedical Res. 1992, 13, Supp. 2, 19
92. Gozes, I., Bodner, M., Shwartz, H., Shani, Y. and Fridkin, M. Peptides 1984, 5, 161.
93. Moody, T.W., Walters, J., Casibang, M., Zia, F. and Gozes, Y. Ann. N.Y. Acad. Sci. 2000, 921, 26
94. Davidson, A., Moody, T.W. and Gozes, I. Molecular and Cellular Neurosci. 1996, 7, 99.
95. Sherwood, N.M., Druecki, S.L. and McRory, J.E. Endocrinology Res. 2000, 21, 619.
96. Reubi, J.C. J. Nucl. Med. 1995, 36, 1846.
97. Reubi, J.C. Ann. N.Y. Acad. Sci. 2000, 921, 1.
98. Robberecht, P., Vertongen, P., Velkeniers, B., de Neef, P., Vergani, P., Raftopoulos, C., Brotchi, J., Hooghe-Peters, E.L. and Christophe, J. J. Clin. Endocrinol. Metab. 1993, 77, 1235.
99. Vertongen, P., Devalck, C., Sariban, E., DeLaet, M.H., Martelli, H., Paraf, F., Helardot, P. and Robberecht, P. J. Cell Physiol. 1996. 167, 36.
100. Reubi, J.C., Laderach, U., Waser, B., Gebbers, J.-O., Robberecht, P. and Laissue, J.A. Cancer Res. 2000, 60, 4636.
101. Moody, T.W., Leyton, J., Unsworth, E., John, C., Lang, L. and Eckelman, W. Peptides 1998, 19, 585.
102. Thakur, M.L., Marcus, C.S., Saeed, S., Pallela, V., Minami, C., Diggles, C., Pham, H.L., Ahdoot, R., Kalinowski, E.A. and Moody, T. Ann. N.Y. Acad. Sci. 2000, 921, 37.
103. Ottaway, C.A., Lay, T.E. and Greenberg, G.R. J. Neuroimmunol. 1990, 29, 149.
104. Goetzl, E.J., Voice, J.K., Shen, S., Dorsam, G., Kong, Y., West, K.M., Morrison, C.F. and Harmar, A.J. Proc. Natl. Acad.Sci. USA 2001, 98, 13854.
105. Dorsio, M.S., Fleshman, D.J., Qualman, S.J. and O'Dorosio, T.M. Reg. Peptides 1992, 37, 213.
106. Fruhwald, M.C., O'Dorisio, M.S., Fleitz, J., Pietsch, T. and Reubi, J.D. Int. J. Cancer 1999, 81, 165.
107. Maruno, K. and Said, S.I. Biomed. Res. 1993, 13, 373.
108. LeLievre, v., Pineau, N., Du, J., Wen, .H., Nguyen, T., Janet, T., Muller, J.M. and Waschek, J.A. J. Biol. Chem. 1998, 273, 19685.
109. Moody, T.W., Czerwinski, G., Tarasova, N.I. and Michejda, C.J. Life Sci. 2002, 71, 1005.
110. Gelber, E., Granoth, R., Fridkin, M., Dreznik, Z., Brenneman, D., Moody, T.W. and Gozes, I. Cancer 2001, 92, 2172.
111. Brazeau, P., Vale, W., Burgus, R., Ling, N., Butscher, M. Rivier, J. and Guilleman, R. Science 1973, 179, 77.
112. Krenning, E.P., Bakker, W.H., Breeman, W.A.P., oper, J.W., Koij, P.P., Auserma, L., Lameris, J.S., Reubi, J.C. and Lamberts, S.W.J. Lancet 1989, 1, 242.
113. Upp, J.R. Jr., Olson, D., Poston, G.J., Alexander, R.W., Townsend, C.M. Jr. and Thompson, J.C. Am. J. Surg, 1988, 155, 29
114. Reubi, J.C.and Laissue, J.A. TIPS 1995, 16, 110.
115. Reubi, J.C., Waser, B., Schaer, J.C. and Laissue, J.A. Eur. J. Nuclear Med. 2001, 28, 836.
116. Taylor, J.E.,, Coy, D.H. and Moreau, J.P. Life Sci. 1988, 43, 421.
117. Taylor, J.E., Moreau, J.P., Baptiste, L. and Moody, T.W. Peptides 1991, 12, 839.
118. Schweitzer, P., Madamba, S. and Siggins, G.R. Nature 1990, 346, 464.
119. Colas, B., Cambillau, C., Buscail, L., Zeggari, M., Esteve, J.P., Lautre, V., Thomas, F., Vaysse, N. and Susni, C. Eur. J. Biochem. 1992, 207, 1017.
120. Sharma, K. and Srikant, C.B. Int. J. Cancer 1998, 76, 259.
121. Patel, Y. Front. Neuroendocrinol. 1999, 20, 157.
122. Resine, T. and Bell, G.I. Endocrine Rev. 1995, 16, 427.
123. Pfeiffer, M., Koch, T., Schroder, H., Klutzny, M., Kirscht, S., Kreienkamp, H.J., Hollt, V. and Schultz, J. Biol. Chem. 2001, 276, 14027.
124. Rocheville, M., Lange, D.C., Kumar, U., Sasi, R., Patel, R.C. and Patel, Y.C. J. Biol. Chem. 2000, 275, 7862.
125. Fruhwald, M.C., O'Dorisio, S., Pietsch, T. and Reubi, J.C. Pediatric Research 1999, 45, 697.
126. Reubi, J.C., Kappeler, A., Waser, B., Laissue, J., Hipkn, R.W. and Schonbrun, A. Am. J. Pathol. 1998, 153, 233.
127. Gibril, F., Reynolds, J.C., Chen, C.C., Yu, F., Goebel, S.U., Serrano, J., Doppman, J.L. and Jensen, R.T. J. Nucl. Med. 1999, 40, 539.
128. John, M. Meyerhof, W., Richter, D., Waser, B., Schaer, J., Scherubl, H.J., Boese-Landgraf, J., Neuhaus, P., ziske, C., Molling, K., Riecken, E., Reubi, J.C. and Wiedenmann, B. Gut 1996, 56, 2561.
129. Behr, T.M., Gotthardt, M., Bardth, A., Behe, M. Q. J. Nucl Med. 2001, 45, 189.
130. Thamason, J.W.W., Martin, R.S. and Fincher, M.E. Clin. Nuc. Med. 2000, 25, 661.
131. Reubi, J.C., Kvols, L., Krenning, E. and Lamberts, S.W.J. Metabolism 1990, 39, 78.
132. Krenning, E.P., Bakker, W.H., Breeman, W.A., Kopere, JW., Kooij, P.O. and Asema, I. Lancet 1989, 1, 242.
133. Krenning, E.P., Kweckkeboom, D.J., Bakker, W.A., Breeman, W.A., Kooij, P.P. and Oei, H.Y. Eur. J. Nucl. Med. 1993, 20, 716.
134. Bohuslavizki, K.H., Brenner, W., Gunther, M., Eberhardt, J.U., Jahn, N. and Tinnemeyer, S. Nucl. Med. Commun. 1996, 17, 191.
135. Behr, R.M., Gratz, S., Markus, P.M., Dunn., R.M., Hufnber, M. and Becker, H. Eur. J. Nucl. Med. 1997, 24, 184.
136. Otte, A., Jermann, E., behe, M., Goetze, M., Bucher, H.C. and Roser, H. W. Eur. J. Nuc. Med. 1997, 24, 792.
137. Kurtaran, A., Leimer, M., Kaserer, K., Yang, Q. Angelberger, P., Niederle, B. Nucl. Med. Biol. 1996, 23, 503.
138. Cerrera, P., Videan, C., Viollet, C., Petracci, C. Lacombe, J., Winsky-Sommerer, R., Csaba, L., Helboe, L., Davmas-Duport, C., Renbi, J.C. and Epelbaun, J. J. Neuroendocrinology, 2003, June 14, 458.
139. Maurer, R. and Reubi, J.C. Mol. Cell Endocrinol. 1986, 45, 81.
140. Reubi, J.C., Kappeler, A., Waser, B., Schonbrunn, A. and Laissue, J.A. J. Clin. Endocrinol. Metab 1998, 83, 3746.
141. LeRomancer, M., Cherifi, Y., Levasseur, S., Loaigneau, J.P., Peranzi, G., Jais, P., Lewin, M.J.M. and Reyl-Desmars, F. Life Sci. 1996, 58, 1091.
142. Schindler, M., Holloway, S., Humphrey, P.P.A., Waldvogel. H., Fauli, R.L., Berger, W. and Emson, P.C. Neuroreport 1998, 9, 521.
143. Reubi, J.C., Laissue, J.A., Waser, B., Steffeti, D.L., Hipkin, R.W. and Schonbrunn, A. J. Clin. Endocrinol. Metab. 1999, 84, 2942.
144. DeJong, M., Bernard, B.F., DeBruin, E., Van Gameren, A., Bakker, W.H., Visser, T.J. and Macke, H.R. Nucl. Med. Commun. 1998, 19, 283.
145. Reubi, J.C., Mazzucchelli, L., Hennig, I. and Laissue, J. Gastroenterology 1996, 110, 1719.
146. Held-Feindt, J., Krisch, B. and Mentlein, R. Brain Res. Mol. Brain Res. 1999, 64, 101.
147. Jensen, R.T. Curr. Opin. Oncol. 2000, 12, 368.
148. Lamberts, S.W., Van Der Lely, A.J., De Herder, W.W. and Hofland, L.J. N. Engl. J. Med. 1996, 334, 246.
149. Shojamanesh, H., Gibril, F., Louie, A., Ojeaburu, J.V., Bashir, S., Abou-Saif, A. and Jensen, R.T. Cancer, 2002, 94, 331.
150. Oberg, K. Curr. Opin. Ondol. 1998, 10, 58.
151. Ingle, J.N., Suman, V.J., Kardinal, C.G., Krook, J.E., Maillliard, J.A., Veeder, N.H., Loprinzi, C.L., Dalton, R.J., Hartmann, L.C., Conover, C.A. and Pollak, M.N. Cancer, 1999, 95, 1284.
152. Fuselier, J., Sun, L., Murphy, W.A., Vasilevitch, N. and Coy, D.H. Proc. Am. Assoc. Cancer Res. 2002, 43, 1157
153. Carraway, R. and Leeman, S.E. J. Biol. Chem. 1973, 248, 6854.
154. Moody, T.W., Mayr, C.A., Gillespie, T. and Davis, T.P. Peptides 1998, 19, 253.
155. Kitabgi, P., Checkler, J., Mazella, J. and Vincent, J.P. Rev. Clin. Basic Pharmacol. 1985, 5, 397.
156. Bourdel, E., Doulut, S., Jarretou, C., Labbe-Jullie, J.A., Fehrentz, O., Coumbi, P., Kitabgi, P. and Martinez, J. Int. J. Pept. Protein Res. 1996, 48, 148.
157. Allen, A.E., Carney, D.N. and Moody, T.W. Peptides 1988, 9, Suppl. 1, 57-61, 1988.
158. Moody, T.W., Chiles, J., Moody, E. and Davis, T.P. Peptides 2001, 22, 109.
159. Staley, J., Fiskum, G., Davis, T.P. and Moody, T.W. Peptides 1999, 10, 1217-1221.
160. Bunn, P.A. Jr., Dienhart, D.G., Chan, D., Puck, T.T., Tagawa, M., Jewett, P.B. and braunschweiger, E. Proc. Natl. Acad. Sci. USA 1990, 87, 2162.
161. Gully, D., Canton, M., Boigegrain, R., Jeanjean, G., Molimard, J.C., Poncelet, M., Guedet, C., Heaulme, M., Leyris, R., Brouard, A., Pelaprat, D., Labbe-Jullie, C., Mazella, J., Sourie, P., Maffrand, J.P., Rostene, W., Kitabgi, P. and LeFur, G. Proc. Natl. Acad.Sci. USA 1993, 90, 65.
162. Gully, D., Labeuw, boigegrain, R., Oury-Donat, F., Bachy, A., Poncelet, M., Steinberg, R., Suaud-Chagny, M.F., Santucci, V., Vita, N., Pecceu, F., Labbe-Jullie, C., Kitabgi, P., soubrie, P., LeFur, G. and Maffrand, J.P. J. Pharmacol. Exp. Ther. 1997, 280, 802.
163. Buhl, A.M., Johnson, N.L., Dhanasekaan and Johnson, G.L. J. Biol. Chem. 1995, 270, 24631.
164. Cox, M.E., Beeble,.P.D., Bissonette, E.A. and Parsons, S.J. J.Biol.Chem. 2000, 275, 13812.
165. Cox, M.E., Deeble, P.D., Lakhani, S. and Parsons, S.J. Cancer Res. 1999, 59, 3821.
166. Salazer, E.P. and Rozengurt, E. J. Biol. Chem. 1999, 274, 28371.
167. Leyton, J.P., Garcia-Marin, L., Jensen, R.T. and Moody, T.W. Eur. J. Pharmacol. 2002, 442, 179.
168. Rodriguez-Fernandez, J.L. and Rozengurt, E. J. Biol. Chem. 1998, 273, 19321.
169. Rozengurt, E. J. Cell Physiol. 1998, 177, 507.
170. Slack, J.K., Adams, R.B., Rovin, J.D., Bissonette, E.A., Stoker, C.E. and Parsons, J.T. Oncogene 2001 20, 1152.
171. Hauck, C.R., Sieg, D.J., sia, D.A., Loftus, J.C., Gaarde, W.A., Monia, B.P. and Schlaepfer, D.D. Cancer Res. 2001, 61, 7079.
172. Agochiya, M., Brunton, V.G., Owens, D.W., Parkinson, E.K., Paraskeva, C., Keith, W.N. and Frame, M.D. Oncogene 1999, 18, 5646.
173. Frisch, S.M., Vuori, K., Raoslahti, E. and Chan-Hui, P.Y. J. Cell Biol. 1996, 134, 793.
174. Akasaka, T., van Leeuwen, R.L., Yoshinaga, I.G., Mihm, M.C. Jr. and Byers, H.R. J. Investig. Dermatol. 1995, 105, 104.
175. Owens, L.V., Xu, L.H., Craven, R.J., Dent, G.A., Weiner, T.M., Kornberg, L., Liu, E.T. and Cance, W.G. Cancer Res. 1995, 55, 252.
176. Wang, D., Grammer, J.R., Cobbs, C.S., Sttewart, J.E., Liu, Z., Rhoden, R., Hecker, T.P., Ding, Q. and Gladson, C.L. J. Cell Sci. 2000, 113, 4221.
177. Reubi, J.C., Waser, B., Schauer, J.C. and Laissue, J.A. Int. J. Cancer 1999, 82, 213.
178. Reubi, J.C., Waser, B., Friess, H., Buchler, M.W. and Laissue, J. Gut 1998, 42, 546.
179. Ehlers, R.A., Kim, S.H., Zhang, Y., Ethridge, R.T., Murilo, C., Hellmich, M.R., Evans, D.B., Townsend, D.M. Jr., Mark Evers, B. Ann. Surg. 2000, 231, 838.
180. Wang, L., Friess, H., Zhu, Z., Graber, H., Zimmermann, A., Korc, M.. Reubi, J.C. and Buchler, M.W. Clin. Cancer Res. 2000, 6, 566.
181. Chavatte, K., Wong, E., Fauconnier, T.K., Lu, L., guyen, T., Roc, D., Pollak, A., Eshima, D., Terriere, D., Mertens, J., Iterbeke, K., Tourwc, D., Thornback, J., Bossuyt, A. J. Labelled Compd. Radiopharm. 1999, 42, 415.
182. Chavatte, K., Merens, J., van den Winckel, P. J. Labelled Compd. Radiopharm. 2000, 43, 1227.
183. Bergmann, R., Scheunemann, M., Heichert, C., Mading, P., Wittrisch, H., Kretzschmar, M., Rodig, H., Tourwe, D., Iterbeke, K., Chavatte, K., Zips, D., Rebi, J.C. and Johannsen, B. Nucl. Med. and Biol. 2002, 29, 61.
184. Davis, T. P., Crowell, S., McInturff, B., Louis, R. and Gillespie, T. Peptides 1991, 12, 17.
185. Chou, T.C. and Talalay, P. Adv. Enzyme Regulation 1984, 273, 161.
186. Blagosklonny, M.V., Schulte, T., Nguyen, P, Trepel, J. and Neckers, L.M. Cancer Res. 1996, 56, 1851.
187. Blum, J., Handmaker, H. and Rinne, N. A. Curr. Pharm. Des. 2002, 8(20), 1827-36.
188. Gomariz, R. P., Martinez, C., Abad, C., Leceta, J. and Delgado, M. Curr. Pharm. Des. 2001, 7(2), 89-111.
189. Virgolini, I., Traub, T., Novotny, C., Leimer, M., Fuger, B., Li, S. R., Patri, P., Pangerl, T., Angelberger, P., Raderer, M., Burggasser, G., Andreae, F., Kurtaran, A. and Dudczak, R. Curr. Pharm. Des. 2002, 8(20), 1781-807.