Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells

European Journal of Pharmacology

Volumn 442, Issue 3, 2002, Pages 179-186

  Leyton, Julius ^a   Garcia Marin, Luis ^b   Jensen, Robert T ^b   Moody, Terry W ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Focal adhesion kinase; Lung cancer; Neurotensin; Proliferation; SR48692

Indexed keywords

2 [[1 (7 CHLORO 4 QUINOLINYL) 5 (2,6 DIMETHOXYPHENYL) 3 PYRAZOLYL]CARBONYLAMINO] 2 ADAMANTANECARBOXYLIC ACID; FOCAL ADHESION KINASE; LEVOCABASTINE; NEUROTENSIN; NEUROTENSIN RECEPTOR; NEUROTENSIN RECEPTOR ANTAGONIST; TYROSINE;

ARTICLE; BINDING AFFINITY; CARCINOMA CELL; CELL ADHESION; CELL CLONE; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; LUNG CARCINOMA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

BINDING, COMPETITIVE; CELL DIVISION; CYTOCHALASIN D; DOSE-RESPONSE RELATIONSHIP, DRUG; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; LUNG NEOPLASMS; NEUROTENSIN; NUCLEIC ACID SYNTHESIS INHIBITORS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PIPERIDINES; PROTEIN-TYROSINE KINASES; PYRAZOLES; QUINOLINES; RECEPTORS, NEUROTENSIN; TUMOR CELLS, CULTURED; TYROSINE;

EID: 0037053099     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)01539-X     Document Type: Article

References (52)

1. Neurotensin binds with high affinity to small cell lung cancer cells
2. Genistein, a specific inhibitor of tyrosine-specific protein kinase
3. Genistein-stimulated adherence of prostate cancer cells is associated with the binding of focal adhesion kinase to beta-1-integrin
4. Nonpeptide antagonists of neuropeptide receptors: Tools for research and therapy
5. Focal adhesion transmembrane junction between the extracellular matrix and the cytoskeleton
6. Establishment and identification of small cell lung cancer cell lines having classic and variant features
7. The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalamus
8. Cas as a mediator of focal adhesion kinase-prompted cell migration
9. Neurotensin: Antinocisponsive action in rodents
10. Neutral endopeptidase: Variable expression in human lung, inactivation in lung cancer and modulation of peptide-induced calcium flux
11. β-endorphin and neurotensin stimulate in vitro clonal growth of human small cell lung cancer cells
12. Neurotensin may function as a regulatory peptide in small cell lung cancer
13. Control of adhesion-dependent cell survival by focal adhesion kinase
14. FAK focal adhesion kinase and paxillin in rat pancreatic acini
15. Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor
16. Biochemical and pharmacological activities of SR142948A, a new potent neurotensin receptor antagonist
17. Focal adhesion protein-tyrosine phosphorylated in response to cell attachment to fibronectin
18. Pharmacology of protein kinase inhibitors
19. An SH3 domain containing GTPase-activating protein for Rho and Cdcrw associates with focal adhesion kinase
20. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
21. Indirect inhibitory effect of a neurotensin receptor antagonist on human colon cancer (LoVo) growth
22. Inhibition of neurotensin-induced pancreatic carcinoma growth by a nonpeptide neurotensin receptor antagonist SR48692
23. Adhesion-linked kinases in cancer: Emphasis on Src, focal adhesion kinase and PI 3-kinase
24. Expression of neurotensin in neuroendocrine tumors
25. Neurotensin: Specific binding to synaptic membranes from rat brain
26. Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase
27. Focal adhesion-associated proteins p125(FAK) and paxillin are substrates for bradykinin-stimulated tyrosine phosphorylation in Swiss 3T3 cells
28. Bombesin and gastrin releasing peptide increase tyrosine phosphorylation of focal adhesion kinase and paxillin in non-small cell lung cancer cells
29. 13,14)Bombesin analogues inhibit the growth of small cell lung cancer in vitro and in vivo
30. The 100 kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor
31. Neurotensin is produced by and secreted from classic small cell lung cancer cells
32. Neurotensin is metabolized by endogenous proteases in prostate cancer cell lines
33. SR48692 inhibits the growth of small cell lung cancer cells
34. Alterations in nociciption and body temperature after intracisternal administration of neurotensin, β-endorphin, other endogenous peptides and morphine
35. FAK) and paxillin tyrosine phosphorylation in Swiss 3T3 cells-Bell shaped dose-response and cross-talk with bombesin
36. Neurotensin receptors in human neoplasms: High incidence in Ewing's sarcomas
37. The hypotensive effect of centrally administered neurotensin in rats
38. Neuropeptides as cellular growth-factors: Role of multiple signaling pathways
39. FAK, a structurally distinctive protein-tyrosine kinase associated with focal adhesions
40. Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains
41. Neurotensin is an autocrine trophic factor stimulated by androgen withdrawal in human prostate cancer
42. Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration
43. Neurotensin elevates cytosolic calcium in small cell lung cancer cells
44. Cholecystokinin-B/gastrin receptors mediate rapid formation of actin stress fibers
45. Expression of focal adhesion kinase in prostate cancer
46. Transcription factor AP-1 regulation by mitogen activated protein kinase signal transduction pathways
47. Bombesin, somatostatin and neurotensin-like immunoreactivity in bronchial carcinoma
48. Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells
49. Distinct functional characteristics of levocabastine sensitive rat neurotensin NT2 receptor expressed in Chinese hamster ovary cells
50. A role for neuropeptides in the control of cell proliferation
51. Bombesin, vasopressin and endothelin rapidly stimulate tyrosine phosphorylation of the focal adhesion-associated protein paxillin in Swiss 3T3 cells
52. Characterization of NT production in medullary thyroid cells