99mTc-labeling and in vivo studies of a bombesin analogue with a novel water-soluble dithiadiphosphine-based bifunctional chelating agent

Bioconjugate Chemistry

Volumn 10, Issue 2, 1999, Pages 254-260

  Karra, Srinivasa R ^a   Schibli, Roger ^a,b   Gali, Hariprasad ^a,b   Katti, Kattesh V ^a   Hoffman, Timothy J ^a,c   Higginbotham, Chris ^c   Sieckman, Gary L ^c   Volkert, Wynn A ^a,c  

^a University of Missouri   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CELL CULTURE; CHELATION; LIGANDS; MAMMALS; PEPTIDES; SYNTHESIS (CHEMICAL);

BIFUNCTIONAL CHELATING AGENT; BOMBESIN ANALOGUES; IN-VIVO; LABELINGS; PEPTIDE RECEPTOR; PHOSPHINE LIGANDS; POST INJECTION; RECENT PROGRESS; VIVO STUDIES; WATERSOLUBLE;

PHOSPHORUS COMPOUNDS;

BOMBESIN; BOMBESIN (7 14); BOMBESIN (7-14); BOMBESIN RECEPTOR; CHELATING AGENT; DRUG DERIVATIVE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; PEPTIDE FRAGMENT; RADIOPHARMACEUTICAL AGENT; TECHNETIUM;

ANIMAL; ARTICLE; BINDING COMPETITION; CELL STRAIN 3T3; CHEMICAL STRUCTURE; CHEMISTRY; ISOTOPE LABELING; KINETICS; METABOLISM; METHODOLOGY; MOUSE; PHYSIOLOGY; RADIOASSAY; SYNTHESIS;

3T3 CELLS; ANIMALS; BINDING, COMPETITIVE; BOMBESIN; CHELATING AGENTS; INDICATORS AND REAGENTS; ISOTOPE LABELING; KINETICS; MICE; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; RECEPTORS, BOMBESIN; TECHNETIUM;

EID: 0032587895     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc980096a     Document Type: Article

References (22)

1. 99mTc Labeling of High Potent Small Peptides. Bioconjugate Chem. 8, 621-636.
2. 99mTc. Q. J. Nucl. Med. 40, 221-233.
3. Moody, T. W., Carney, D. N., Cuttita, F., Quattrocchi, K., and Minna, J. D. (1985) High affinity of receptors for bombesin/GRP-like peptides on human small cell cancer. Life Sci. 37, 105-113.
4. Qin, Y., Ertl, T., Cai, R. Z., Halmos, G., and Schally, A. V. (1994) Inhibitory effect of bombesin receptor antagonist RC-3095 on the growth of human pancreatic cancer cells in vivo and in vitro. Cancer Res. 54, 1035-1041.
5. Pinski, J., Schally, A. V., Halmos, G., Yano, T., Szepeshazi, K., and Groot, K. (1994) Somatostatin analogues and bombesin/gastrin releasing peptide antagonist RC-3095 inhibit the growth of glioblastomas in vitro and in vivo. Cancer Res. 54, 5895-5901.
6. Radulovic, S., Miller, G., and Schally, A. V. (1991) Inhibition of growth of HT-29 human colon cancer xenografs in nude mice by treatment with bombesin/gastrin releasing peptide antagonist (RC-3095). Cancer Res. 51, 6006-6009.
7. Jensen, R. T., Jones, S. W., Folkers, K., and Gardner, J. D. (1984) A synthetic peptide that is a bombesin receptor antagonist. Nature 309, 61-63.
8. Safavy, A., Khazaeli, M. B., Qin, H., and Buchsbaum, D. J. (1997) Synthesis of Bombesin Analogues for Radiolabeling with Rhenium-188. Cancer Suppl. 80, 2354-2359.
9. Baidoo, K. E., Lin, K.-S., Zhan, Y., Finley, P., Scheffel, U., and Wagner, H. N., Jr. (1998) Design, Synthesis, and Initial Evaluation of High-Affinity Technetium Bombesin Analogues. Bioconjugate Chem. 9, 218-225.
10. Hoffman, T. J., Sieckman, G. L., and Volkert, W. A. (1995) Targeting Small Cell Lung Cancer Using Iodinated Peptide Analogs. J. Labelled Comp. Radiopharm. 37, 321-323.
11. Li, N., Hoffman, T. J., Sieckman, G. L., Ochrymowycz, L. A., Higginbotham, C., Strutman, M., Volkert, W. A., and Ketring, A. R. (1996) In vitro and in vivo characterization of Rh-105-Tetrathiamacrocycle conjugate of a bombesin analogue. J. Nucl. Med. 37 (Suppl.), 61P.
12. 99mTc. Bioconjugate Chem. 8, 155-160.
13. 99mTc. Bioconjugate Chem. 8, 146-154.
14. 2. Inorg. Chem. 36, 1786-1791.
15. 2](Cl). Inorg. Chem. 36, 3928-3935.
16. 99mTc Complexes. J. Nucl. Med. Biol. 24, 685-691.
17. 99mTc Complex. Radiochim. Acta (In press).
18. Wagner, A. F., Walton, E., Boxer, G. E., Pruss, M. P., Holly, F. W., and Folkers, K. (1956) Properties and derivatives of α-lipoic acid. J. Am. Chem. Soc. 78, 5079-5081.
19. + type ions. Inorg. Chem. 4, 797-803.
20. Mahmoud, S., Stanley, J., Taylor, J., Bogden, A., Moreau, J. P., Coy, D., Avis, I., Cuttitta, F., Mulshine, J. L., and Moody, T. W. (1991) [Psi 13, 14] bombesin analogues inhibit growth of small cell lung cancer in vitro and in vivo. Cancer Res. 51, 1798-1802.
21. Barton, F. H. R., Herve, Y., Potier, P., and Thierry, J. (1988) Manipulation of the carboxylic groups of α-amino acids and peptides using radical chemistry based on esters of N-hydroxy-2-thiopyridone. Tetrahedron 44, 5479-5486.
22. Moody, T. W., Venugopal, R., Hu, V., Gozes, Y., McDermed, J., and Leban, J. J. (1996) BW 1023490: A new GRP receptor antagonist for small-cell lung cancer cells. Peptides 17, 1337-1343.