Role of DNA break-sensing molecule poly(ADP-ribose) polymerase (PARP) in cellular function and radiation toxicity

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 65, Issue , 2000, Pages 583-591

  Tong, W M ^a   Galendo, D ^a   Wang, Z Q ^a  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; FREE RADICAL; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NUCLEAR PROTEIN; PROTEIN P53;

ANIMAL CELL; CELL CULTURE; CELL DEATH; CELL IMMORTALIZATION; CONFERENCE PAPER; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; FIBROBLAST; GENE DISRUPTION; IONIZING RADIATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN MODIFICATION; ANIMAL; ARTICLE; CELL DIVISION; CYTOLOGY; FERTILITY; GENETIC RECOMBINATION; GENETICS; METABOLISM; MOUSE MUTANT; NUTRITIONAL DEFICIENCY; PHYSIOLOGY; RADIATION EXPOSURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL FUNCTION; CELL PROLIFERATION; DNA DAMAGE RESPONSE; EMBRYO; GAMMA IRRADIATION; PROTEIN PROTEIN INTERACTION; RADIATION INJURY; RADIATION RESPONSE; RADIOSENSITIVITY; THYMOCYTE;

ANIMALIA;

ANIMAL; CELL DIVISION; CELLS, CULTURED; DNA DAMAGE; DNA REPAIR; FERTILITY; FIBROBLASTS; MICE; MICE, KNOCKOUT; POLY(ADP-RIBOSE) POLYMERASES; RECOMBINATION, GENETIC; SUPPORT, NON-U.S. GOV'T;

EID: 0034437669     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2000.65.583     Document Type: Conference Paper

References (52)

1. ADP-ribosylation of proteins. Enzymology and biological significance
2. Defective induction but normal activation and function of p53 in mouse ceils lacking poly-ADP-ribose polymerase
3. PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase
4. pADPRT-2: A novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans
5. Poly(ADP-ribose) in the cellular response to DNA damage
6. Analysis of poly(ADP-ribose) glycohydrolase activity in nuclear extracts from mammalian cells
7. Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin
8. Changes in activity and mRNA levels of poly(ADP-ribose) polymerase during rat liver regeneration
9. Thymocytes apoptosis induced by p53 dependent and independent pathway
10. A p53-dependent mouse spindle checkpoint
11. Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability
12. Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions
13. Poly(ADPribosyl)ation system in transcriptionally active rat testis chromatin fractions
14. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
15. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
16. Ischemic brain injury is mediated by the activation of poly(ADP-ribose) polymerase
17. Abnormal centrosome amplification in the absence of p53
18. Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span
19. p53 mutations in human cancers
20. DNA repair: PARP - Another guardian angel?
21. A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues
22. The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase
23. Cellular responses to DNA damage in the absence of poly(ADP-ribose) polymerase
24. p53, the cellular gatekeeper for growth and division
25. Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks
26. p53 is required for radiation induced apoptosis in mouse thymocytes
27. Mitotic misregulation and human aging
28. Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions
29. Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism
30. The response of PARP knockout mice against DNA damaging agents
31. Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes
32. Changes in mRNA levels of poly(ADP-ribose) polymerase during activation of human lymphocytes
33. Induction of poly(ADP-ribose) polymerase gene expression in lectin-stimulated human T lymphocytes is dependent on protein synthesis
34. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
35. Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis
36. Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians
37. Striking similarity of the distribution patterns of the poly(ADP-ribose) polymerase and DNA polymerase beta among various mouse organs
38. Involvement of Brca2 in DNA repair
39. Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes
40. Poly(ADPribosyl)ation system in rat germinal ceils at different stages of differentiation
41. Characterization of sPARP-1. An alternative product of PARP-1 gene with poly(ADP-ribose) polymerase activity independent of DNA strand breaks
42. Compensatory expression of p73 in PARP-deficient mouse fibroblasts as response to a reduced level of regularly spliced wildtype p53 protein
43. -/- mice: Genome stabilization in immortalized ceils by reintroduction of PARP cDNA
44. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
45. Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells
46. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
47. Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease
48. PARP is important for genomic stability but dispensable in apoptosis
49. ADP-ribosylation of p53 tumor suppressor protein: Mutant but not wild-type p53 is modified
50. ADP-ribosylation of wild-type p53 in vitro: Binding of p53 protein to specific p53 consensus sequence prevents its modification
51. Reduced stability of regularly spliced but not alternatively spliced p53 protein in PARP-deficient mouse fibroblasts
52. Atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity