Induction of the early growth response gene 1 promoter by TCR agonists and partial agonists: Ligand potency Is related to sustained phosphorylation of extracellular signal-related kinase substrates

Journal of Immunology

Volumn 170, Issue 1, 2003, Pages 315-324

  Xi, Hongkang ^a   Kersh, Gilbert J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; PARTIAL AGONIST; SERUM RESPONSE FACTOR; T LYMPHOCYTE RECEPTOR;

AGONIST; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME SUBSTRATE; GENE ACTIVATION; GENE EXPRESSION; GENE INDUCTION; LYMPHOCYTOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN STABILITY; SERUM RESPONSIVE ELEMENT; T LYMPHOCYTE;

EID: 0037218502     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.1.315     Document Type: Article

References (63)

1. Kersh, G. J., and P. M. Allen. 1996. Essential flexibility in the T-cell recognition of antigen. Nature 222:495.
2. De Magistris, M. T., J. Alexander, M. Coggeshall, A. Altman, F. C. A. Gaeta, H. M. Grey, and A. Sette. 1992. Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. Cell 68:625.
3. Evavold, B. D., and P. M. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252:1308.
4. Hogquist, K. A., S. C. Jameson, W. R. Heath, J. L. Howard, M. J. Bevan, and F. R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76:17.
5. Tanchot, C., F. A. Lemonnier, B. Pérarnau, A. A. Freitas, and B. Rocha. 1997. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276:2057.
6. Kirberg, J., A. Berns, and H. von Boehmer. 1997. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules. J. Exp. Med. 186:1269.
7. Viret, C., F. S. Wong, and C. A. Janeway, Jr. 1999. Designing and maintaining the mature TCR repertoire: The continuum of self-peptide:self-MHC complex recognition. Immunity 10:559.
8. + T cells in the absence of self peptide:MHC complexes. J. Immunol. 165:2458.
9. + T cell survival is not directly linked to self-MHC-induced TCR signaling. Nat. Immunol. 1:329.
10. Laufer, T. M., L. Fan, and L. H. Glimcher. 1999. Self-reactive T cells selected on thymic cortical epithelium are polyclonal and are pathogenic in vivo. J. Immunol. 162:5078.
11. Davis, M. M., J. J. Boniface, Z. Reich, D. Lyons, J. Hampl, B. Arden, and Y.-H. Chien. 1998. Ligand recognition by αβ T cell receptors. Annu. Rev. Immunol. 16:523.
12. Kersh, E. N., A. S. Shaw, and P. M. Allen. 1998. Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation. Science 281:572.
13. Kersh, E. N., G. J. Kersh, and P. M. Allen. 1999. Partially phosphorylated T cell receptor ζ molecules can inhibit T cell activation. J. Exp. Med. 190:1627.
14. Hedrick, S. M. 2002. T cell development: Bottoms-up. Immunity 16:619.
15. 1 transition in cultured cells. EMBO J. 7:29.
16. Milbrandt, J. 1987. A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science 238:797.
17. Sukhatme, V. P., X. M. Cao, L. C. Chang, C. H. Tsai-Morris, D. Stamenkovich, P. C. Ferreira, D. R. Cohen, S. A. Edwards, T. B. Shows, T. Curran, et al. 1988. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell 53:37.
18. McMahon, S. B., and J. G. Monroe. 1996. The role of early growth response gene i (egr-1) in regulation of the immune response. J. Leukocyte Biol. 60:159.
19. Shao, H., D. H. Kono, L.-Y. Chen, E. M. Rubin, and J. Kaye. 1997. Induction of the early growth response (Egr) family of transcription factors during thymic selection. J. Exp. Med. 185:731.
20. Basson, M. A., T. J. Wilson, G. A. Legname, N. Samer, P. D. Tomlinson, V. L. Tybulewicz, and R. Zamoyska. 2000. Early growth response (Egr)-l gene induction in the thymus in response to TCR ligation during early steps in positive selection is not required for CD8 lineage commitment. J. Immunol. 165:2444.
21. Bettini, M., H. Xi, J. Milbrandt, and G. J. Kersh. 2002. Thymocyte development in early growth response gene 1-deficient mice. J. Immunol. 169;1713.
22. + stage. J. Immunol. 168:1649.
23. Alexandropoulos, K., S. A. Qureshi, M. Rim, V. P. Sukhatme, and D. A. Foster. 1992. v-Fps-responsiveness in the Egr-1 promoter is mediated by serum response elements. Nucleic Acids Res. 20:2355.
24. Bemal-Mizrachi, E., B. Wice, H. Inoue, and M. A. Permutt. 2000. Activation of serum response factor in the depolarization induction of Egr-1 transcription in pancreatic islet β cells. J. Biol. Chem. 275:25681.
25. Chauhan, D., S. M. Kharbanda, H. Uchiyama, V. P. Sukhatme, D. W. Kufe, and K. C. Anderson. 1994. Involvement of serum response element in okadaic acidinduced EGR-1 transcription in human T-cells. Cancer Res. 54:2234.
26. Christy, B., and D. Nathans. 1989. Functional serum response elements upstream of the growth factor-inducible gene zif268. Mol. Cell. Biol. 9:4889.
27. Clarkson, R. W., C. A. Shang, L. K. Levitt, T. Howard, and M. J. Waters. 1999. Ternary complex factors Elk-1 and Sap-1a mediate growth hormone-induced transcription of egr-1 (early growth response factor-1) in 3T3-F442A preadipocytes. Mol. Endocrinol. 13:619.
28. Datta, R., E. Rubin, V. Sukhatme, S. Qureshi, D. Hallahan, R. R. Weichselbaum, and D. W. Kufe. 1992. Ionizing radiation activates transcription of the EGR1 gene via CArG elements. Proc. Natl. Acad. Sci. USA 89:10149.
29. DeFranco, C., D. H. Damon, M. Endoh, and J. A. Wagner. 1993. Nerve growth factor induces transcription of NGFIA through complex regulatory elements that are also sensitive to serum and phorbol 12-myristate 13-acetate. Mol. Endocrinol. 7:365.
30. Duan, W. R., M. Ito, Y. Park, E. T. Maizels, M. Hunzicker-Dunn, and J. L. Jameson. 2002. GnRH regulates early growth response protein 1 transcription through multiple promoter elements. Mol. Endocrinol. 16:221.
31. Kharbanda, S., A. Saleem, E. Rubin, V. Sukhatme, J. Blenis, and D. Kufe. 1993. Activation of the early growth response 1 gene and nuclear pp90rsk in human myeloid leukemia cells by 1-(β-D-arabinofuranosyl)cytosine. Biochemistry 32:9137.
32. McMahon, S. B., and J. G. Monroe. 1995. A ternary complex factor-dependent mechanism mediates induction of egr-1 through selective serum response elements following antigen receptor cross-linking in B lymphocytes. Mol. Cell. Biol. 15:1086.
33. Meyer, R. G., J. H. Kupper, R. Kandolf, and H. P. Rodemann. 2002. Early growth response-1 gene (Egr-1) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro. Eur. J. Biochem. 269:337.
34. Mora-Garcia, P., and K. M. Sakamoto. 2000. Granulocyte colony-stimulating factor induces Egr-1 up-regulation through interaction of serum response element-binding proteins. J. Biol. Chem. 275:22418.
35. Qureshi, S. A., X. M. Cao, V. P. Sukhatme, and D. A. Foster. 1991. v-Src activates mitogen-responsive transcription factor Egr-1 via serum response elements. J. Biol. Chem. 266:10802.
36. Rim, M., S. A. Qureshi, D. Gius, J. Nho, V. P. Sukhatme, and D. A. Foster. 1992. Evidence that activation of the Egr-1 promoter by v-Raf involves serum response elements. Oncogene 7:2065.
37. Rupprecht, H. D., V. P. Sukhatme, J. Lacy, R. B. Sterzel, and D. L. Coleman. 1993. PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements. Am. J. Physiol. 265:F351.
38. Sakamoto, K. M., J. K. Fraser, H. J. Lee, E. Lehman, and J. C. Gasson. 1994. Granulocyte-macrophage colony-stimulating factor and interleukin-3 signaling pathways converge on the CREB-binding site in the human egr-1 promoter. Mol. Cell. Biol. 14:5975.
39. Kharbanda, S., E. Rubin, R. Datta, R. Hass, V. Sukhatme, and D. Kufe. 1993. Transcriptional regulation of the early growth response 1 gene in human myeloid leukemia cells by okadaic acid. Cell Growth Differ. 4:17.
40. Kersh, G. J., and P. M. Allen. 1996. Structural basis for T cell recognition of altered peptide ligands: A single T cell receptor can productively recognize a large continuum of related ligands. J. Exp. Med. 184:1259.
41. Xi, H., D. D. Eason, D. Ghosh, S. Dovhey, K. L. Wright, and G. Blanck. 1999. Co-occupancy of the interferon regulatory element of the class II transactivator (CIITA) type IV promoter by interferon regulatory factors 1 and 2. Oncogene 18:5889.
42. Tsai-Morris, C. H., X. M. Cao, and V. P. Sukhatme. 1988. 5′ flanking sequence and genomic structure of Egr-1, a murine mitogen inducible zinc finger encoding gene. Nucleic Acids Res. 16:8835.
43. Treisman, R. 1994. Ternary complex factors: Growth factor regulated transcriptional activators. Curr. Opin. Genet. Dev. 4:96.
44. Rao, V. N., K. Huebner, M. Isobe, A. Ar-Rushdi, C. M. Croce, and E. S. Reddy. 1989. Elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints. Science 244:66.
45. Dalton, S., and R. Treisman. 1992. Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. Cell 68:597.
46. Zinck, R., R. A. Hipskind, V. Pingoud, and A. Nordheim. 1993. c-fos transcriptional activation and repression correlate temporally with the phosphorylation status of TCF. EMBO J. 12:2377.
47. Chan, Y. J., C. J. Chiou, Q. Huang, and G. S. Hayward. 1996. Synergistic interactions between overlapping binding sites for the serum response factor and ELK-l proteins mediate both basal enhancement and phorbol ester responsiveness of primate cytomegalovirus major immediate-early promoters in monocyte and T-lymphocyte cell types. J. Virol. 70:8590.
48. Malik, R. K., M. W. Roe, and P. J. Blackshear. 1991. Epidermal growth factor and other mitogens induce binding of a protein complex to the c-fos serum response element in human astrocytoma and other cells. J. Biol. Chem. 266:8576.
49. Marais, R., J. Wynne, and R. Treisman. 1993. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73:381.
50. Gille, H., A. D. Sharrocks, and P. E. Shaw. 1992. Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 358:414.
51. Greene, L. A., and A. S. Tischler. 1976. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. USA 73:2424.
52. Huff, K., D. End, and G. Guroff. 1981. Nerve growth factor-induced alteration in the response of PC 12 pheochromocytoma cells to epidermal growth factor. J. Cell Biol. 88:189.
53. Marshall, C. J. 1995. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179.
54. Qu, Z., L. A. Wolfraim, J. Svaren, M. U. Ehrengruber, N. Davidson, and J. Milbrandt. 1998. The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells. J. Cell Biol. 142:1075.
55. Chau, L. A., J. A. Bluestone, and J. Madrenas. 1998. Dissociation of intracellular signaling pathways in response to partial agonist ligands of the T cell receptor. J. Exp. Med. 187:1699.
56. Werlen, G., B. Hausmann, and E. Palmer. 2000. A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity. Nature 406:422.
57. Kersh, G. J., E. N. Kersh, D. H. Fremont, and P. M. Allen. 1998. High- and low-potency ligands with similar affinities for the TCR: The importance of kinetics in TCR signaling. Immunity 9:817.
58. Boniface, J. J., J. D. Rabinowitz, C. Wülfing, J. Hampl, Z. Reich, J. D. Altman, R. M. Kantor, C. Beeson, H. M. McConnell, and M. M. Davis. 1998. Initiation of signal transduction through the T cell receptor requires the peptide multivalent engagement of MHC ligands. Immunity 9:459.
59. Zhang, W., J. Sloan-Lancaster, J. Kitchen, R. P. Trible, and L. E. Samelson. 1998. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92:83.
60. Sloan-Lancaster, J., and P. M. Allen. 1996. Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14:1.
61. Chau, L. A., and J. Madrenas. 1999. Phospho-LAT-independent activation of the ras-mitogen-activated protein kinase pathway: A differential recruitment model of TCR partial agonist signaling. J. Immunol. 163:1853.
62. Dower, N. A., S. L. Stang, D. A. Bottorff, J. O. Ebinu, P. Dickie, H. L. Ostergaard, and J. C. Stone. 2000. RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nat. Immunol. 1:317.
63. Howe, L. R., S. J. Leevers, N. Gomez, S. Nakielny, P. Cohen, and C. J. Marshall. 1992. Activation of the MAP kinase pathway by the protein kinase raf. Cell 71:335.