ARF function does not require p53 stabilization or Mdm2 relocalization

Molecular and Cellular Biology

Volumn 22, Issue 1, 2002, Pages 196-206

  Korgaonkar, C ^a   Zhao, L ^a   Modestos, M ^a   Quelle, D E ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE READING FRAME PRODUCT; COMPLEMENTARY DNA; GENE PRODUCT; ONCOPROTEIN; PROTEIN P53; RIBOSOME DNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL GROWTH; CELL STRAIN 3T3; DNA CONTENT; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE; OSTEOSARCOMA CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REPORTER GENE; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE;

3T3 CELLS; ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; ANIMALS; CELL CYCLE; CELL DIVISION; CELL LINE; CELL NUCLEOLUS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FLOW CYTOMETRY; GENES, REPORTER; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; MURINAE;

EID: 0036133108     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.1.196-206.2002     Document Type: Article

References (66)

1. The p53 network
2. High-efficiency transformation of mammalian cells by plasmid DNA
3. Stabilization and activation of p53 are regulated independently by different phosphorylation events
4. The INK4a/ARF tumor suppressor: One gene-two products-two pathways
5. Inhibition of v-Abtransformation by p53 and p19ARF
6. E1A signaling to p53 involves the p19(ARF) tumor suppressor
7. Solution structure of the p53 regulatory domain of the p19ARF tumor suppressor protein
8. Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor
9. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
10. Disruption of the ARF-Mdm2-53 tumor suppressor pathway in Mycinduced lymphomagenesis
11. Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status
12. Human ARF binds E2F1 and inhibits its transcriptional activity
13. Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
14. Net results of nucleolar dynamics
15. The complexity of p53 modulation: Emerging patterns from divergent signals
16. p300/Mdm2 complexes participate in Mdm2-mediated p53 degradation
17. Database of p53 gene somatic mutations in human tumors and cell lines: Updated compilation and future prospects
18. In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice
19. Mdm2 promotes the rapid degradation of p53
20. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
21. Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
22. Small peptides activate the latent sequence-specific DNA binding function of p53
23. p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by Mdm2
24. MdmX binding to ARF affects Mdm2 protein stability and p53 transactivation
25. Functional and physical interactions of the ARF tumor suppressor with p53 and mdm2
26. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19(ARF)
27. Human ARF protein interacts with topoisomerase I and stimulates its activity
28. Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion
29. p53: Puzzle and paradigm
30. Regulation of p53 stability by Mdm2
31. p53, the cellular gatekeeper for growth and division
32. Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation
33. Immunolocalization of human p14ARF to the granular component of the interphase nucleolus
34. Stabilisation of p53 by pl4ARF without relocalization of Mdm2 to the nucleolus
35. Contribution of two independent MDM2-binding domains in p14(ARF) to p53 stabilization
36. Identification of a cryptic nucleolar-localization signal in MDM2
37. Quantitative variation of the common acute lymphoblastic leukemia antigen (gp100) on leukemic marrow blasts
38. p19ARF targets certain E2F species for degradation
39. An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo
40. Aberrations of the p53 pathway components p53 MDM2 and CDKN2A appear independent in diffuse large B cell lymphoma
41. Mdm-2: "Big brother" of p53
42. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
43. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
44. p19ARF links the tumour suppressor p53 to Ras
45. The INK4a tumor suppressor gene product, p19(ARF), interacts with mdm2 and neutralizes mdm2s inhibition of p53
46. Cancerassociated mutations at the INK4a locus cancel cell cycle arrest by p16(INK4A) but not by the alternative reading frame protein p19(ARF)
47. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
48. Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization
49. Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein
50. The p16lNK4a/CDKN2A tumor suppressor and its relatives
51. Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer
52. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
53. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16(INK4a)
54. Tumor surveillance via the ARF-p53 pathway
55. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
56. Pex19p dampens the p19ARF-WAF1 tumor suppressor pathway
57. Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53
58. P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2
59. The human tumor suppressor ARF interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein
60. p53-independent functions of the p19ARF tumor suppressor
61. Cooperative signals governing ARFMdm2 interaction and nucleolar localization of the complex
62. Nucleolar Arf sequesters Mdm2 and activates p53
63. DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
64. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
65. Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
66. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization