Requirement for C-terminal end of fibroblast growth factor receptor 4 in translocation of acidic fibroblast growth factor to cytosol and nucleus

Journal of Cell Science

Volumn 113, Issue 10, 2000, Pages 1827-1838

  Klingenberg, Olav ^a   Wiedłocha, Antoni ^a   Rapak, Andrzej ^a   Khnykin, Denis ^a   Citores, Lucia ^a   Olsnes, Sjur ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Cell nucleus; Fibroblast growth factor; Fibroblast growth factor receptor

Indexed keywords

ACIDIC FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; PROTEIN KINASE C; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL NUCLEUS; CELL STRAIN COS1; CELL SURFACE; CENTRIFUGATION; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; ENDOCYTOSIS; ENZYME ACTIVATION; GENETIC TRANSFECTION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT;

ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL MEMBRANE; CELL NUCLEUS; COS CELLS; CYTOSOL; ENDOCYTOSIS; FIBROBLAST GROWTH FACTOR 1; GENE DELETION; PHOSPHOTRANSFERASES; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, FIBROBLAST GROWTH FACTOR; TRANSFECTION;

ANIMALIA;

EID: 0342424259     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Bhakdi, S., Weller, U., Walev, I., Martin, E., Jonas, D. and Palmer, M. (1993). A guide to the use of pore-forming toxins for controlled permeabilization of cell membranes. Med. Microbiol. Immunol. (Berl) 182, 167-175.
2. Burgess, W. H. and Maciag, T. (1989). The heparin-binding (fibroblast) growth factor family of proteins. Annu. Rev. Biochem. 58, 575-606.
3. Burgess, W. H., Shaheen, A. M., Ravera, M., Jaye, M., Donohue, P. J. and Winkles, J. A. (1990). Possible dissociation of the heparin-binding and mitogenic activities of heparin-binding (acidic fibroblast) growth factor-1 from its receptor-binding activities by site-directed mutagenesis of a single lysine residue. J. Cell Biol. 111, 2129-2138.
4. Burrus, L. W., Zuber, M. E., Lueddeckc, B. A. and Olwin, B. B. (1992). Identification of a cysteine-rich receptor for fibroblast growth factors. Mol. Cell Biol. 12, 5600-5609.
5. Casey, P. and Seabra, M. (1996). Protein prenyltransferases. J. Biol. Chem. 271, 5289-5292.
6. Chellaiah, A. T., McEwen, D. G., Werner, S., Xu, J. and Ornitz, D. M. (1994). Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1. J. Biol. Chem. 269, 11620-11627.
7. Chen, Y. J. and Gonatas, N. K. (1997). The Golgi sialoglycoprotein MG160, expressed in Pichia pastoris, does not require complex carbohydrates and sialic acid for secretion and basic fibroblast growth factor binding. Biochem. Biophys. Res. Commun. 234, 68-72.
8. Citores, L., Wesche, J., Kolpakova, E. and Olsnes, S. (1999). Uptake and intracellular transport of acidic fibroblast growth factor: evidence for free and cytoskeleton-anchored fibroblast growth factor receptors. Mol. Biol. Cell 10, 3835-3848.
9. Couet, J., Sargiacomo, M. and Lisanti, M. P. (1997). Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities. J. Biol. Chem. 272, 30429-30438.
10. Falnes, P. O. and Olsnes, S. (1995). Cell-mediated reduction and incomplete membrane translocation of diphtheria toxin mutants with internal disulfides in the A fragment. J. Biol. Chem. 270, 20787-20793.
11. Falnes, P. O., Wiedłocha, A., Rapak, A. and Olsnes, S. (1995). Famesylation of CaaX-tagged diphtheria toxin A-fragment as a measure of transfer to the cytosol. Biochemistry 34, 11152-11159.
12. Friesel, R. and Maciag, T. (1988). Internalization and degradation of heparin binding growth factor-I by endothelial cells. Biochem. Biophys. Res. Commun. 151, 957-964.
13. Gleizes, P. E., Noaillac-Depeyre, J., Dupont, M. A. and Gas, N. (1996). Basic fibroblast growth factor (FGF-2) is addressed to caveolae after binding to the plasma membrane of BHK cells. Eur. J. Cell Biol. 71, 144-153.
14. Hou, J. Z., Kan, M. K., McKeehan, K., McBride, G., Adams, P. and McKeehan, W. L. (1991). Fibroblast growth factor receptors from liver vary in three structural domains. Science 251, 665-668.
15. Hug, H. and Sarre, T. F. (1993). Protein kinase C isoenzymes: divergence in signal transduction? Biochem. J. 291, 329-343.
16. Imamura, T., Engleka, K., Zhan, X., Tokita, Y., Forough, R., Roeder, D., Jackson, A., Maier, J. A., Hla, T. and Maciag, T. (1990). Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence. Science 249, 1567-1570.
17. Imamura, T., Oka, S., Tanahashi, T. and Okita, Y. (1994). Cell cycle-dependent nuclear localization of exogenously added fibroblast growth factor-1 in BALB/c 3T3 and human vascular endothelial cells. Exp. Cell Res. 215, 363-372.