Permeable FGF-1 nuclear localization signal peptide stimulates DNA synthesis in various cell types but is cell-density sensitive and unable to support cell proliferation

Experimental Cell Research

Volumn 243, Issue 2, 1998, Pages 408-414

  Komi, Akiko ^a   Suzuki, Masashi ^a   Imamura, Toru ^a  

^a NATL INST BIOSCI HUM TECHNOL   (Japan)

Author keywords

DNA synthesis; Endothelial cell; Fibroblast growth factor; Hepatocyte; Nuclear localization signal; Permeable peptide

Indexed keywords

CELL DNA; FIBROBLAST GROWTH FACTOR 1;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL DENSITY; CELL NUCLEUS; CELL PROLIFERATION; CELL TYPE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ANIMALIA; MURINAE;

EID: 0032531255     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1998.4176     Document Type: Article

References (21)

1. Baird A., Klagsbrun M. The fibroblast growth factor family. Cancer Cells. 3:1991;239-243.
2. Tanaka A., Miyamoto K., Minamino N., Takeda M., Sato B., Matsuo H., Matsumoto K. Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. Proc. Natl. Acad. Sci. USA. 89:1992;8928-8932.
3. Miyamoto M., Naruo K., Seko C., Matsumoto S., Kondo T., Kurokawa T. Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. Mol. Cell. Biol. 13:1993;4251-4259.
4. Yamasaki M., Miyake A., Tagashira S., Itoh N. Structure and expression of the rat mRNA encoding a novel member of the fibroblast growth factor family. J. Biol. Chem. 271:1996;15918-15921.
5. Smallwood P. M., Munoz-Sanjuan I., Tong P., Macke J. P., Hendry S. H. C., Gilbert D. J., Copeland N. G., Jenkins N. A., Nathans J. Fibroblast growth factor (FGF) homologous factors: New members of the FGF family implicated in nervous system development. Proc. Natl. Acad. Sci. USA. 93:1996;9850-9857.
6. McWhirter J. R., Goulding M., Weiner J. A., Chun J., Murre C. A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. Development. 124:1997;3221-3232.
7. Johnson D. E., Williams L. T. Structural and functional diversity in the FGF receptor multigene family. Adv. Cancer Res. 60:1993;1-41.
8. Jaye M., Schlessinger J., Dionne C. A. Fibroblast growth factor receptor tyrosine kinases: Molecular analysis and signal transduction. Biochim. Biophys. Acta. 1135:1992;185-199.
9. Kouhara H., Hadari Y. R., Spivak-Kroizman T., Schilling J., Bar-Sagi D., Lax I., Schlessinger J. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell. 89:1997;693-702.
10. Lin Y-Z., Yao S. Y., Hawiger J. Role of the nuclear localization sequence in fibroblast growth factor-1-stimulated mitogenic pathways. J. Biol. Chem. 271:1996;5305-5308.
11. Imamura T., Engleka K., Zhan X., Tokita Y., Forough R., Roeder D., Jackson A., Maier J. A. M., Hla T., Maciag T. Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence. Science. 249:1990;1567-1570.
12. Imamura T., Tokita Y., Mitsui Y. Identification of a heparin-binding growth factor-1 nuclear translocation sequence by deletion mutation analysis. J. Biol. Chem. 267:1992;5676-5679.
13. Wiedlocha A., Falnes P. O., Madshus I. H., Sandvig K., Olsnes S. Dual mode of signal transduction by externally added acidic fibroblast growth factor. Cell. 76:1994;1039-1051.
14. Luo Y., Gabriel J. L., Wang F., Zhan X., Maciag T., Kan M., McKeehan W. L. Molecular modeling and deletion mutagenesis implicate the nuclear translocation sequence in structural integrity of fibroblast growth factor-1. J. Biol. Chem. 271:1996;26876-26883.
15. Imamura T., Oka S., Tanahashi T., Okita Y. Cell cycle-dependent nuclear localization of exogenously added fibroblast growth factor-1 in BALB/c 3T3 and human vascular endothelial cells. Exp. Cell Res. 215:1994;363-372.
16. Imamura T., Mitsui Y. Heparan sulfate and heparin as a potentiator or a suppressor of normal and transformed vascular endothelial cells. Exp. Cell Res. 172:1987;92-100.
17. Tanahashi T., Suzuki M., Imamura T., Mitsui Y. Re-evaluation of FGF-1 as a potent mitogen for hepatocytes. In Vitro Cell. Dev. Biol. 30A:1994;139-141.
18. Uhlrich S., Tiollier J., Tardy M., Tayot J-L. Isolation and characterization of two different molecular forms of basic fibroblast growth factor extracted from human placental tissue. J. Chromatogr. 539:1991;393-403.
19. Zhan X., Hu X., Friedman S., Maciag T. Analysis of endogenous and exogenous nuclear translocation of fibroblast growth factor-1 in NIH 3T3 cells. Biochem. Biophys. Res. Commun. 188:1992;982-991.
20. Mason I. J. The ins and outs of fibroblast growth factors. Cell. 78:1994;547-552.
21. Wiedlocha A., Falnes P. O., Rapak A., Munoz R., Klingenberg O., Olsnes S. Stimulation of proliferation of a human osteosarcoma cell line by exogenous acidic fibroblast growth factor requires both activation of receptor tyrosine kinase and growth factor internalization. Mol. Cell. Biol. 16:1996;270-280.