Structural regions of ERα critical for synergistic transcriptional responses contain co-factor interacting surfaces

Molecular and Cellular Endocrinology

Volumn 192, Issue 1-2, 2002, Pages 171-185

  Sathya, Ganesan ^a   Yi, Ping ^a   Bhagat, Sumedha ^a   Bambara, Robert A ^a   Hilf, Russell ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Co factors; ER ; Structure function; Synergy; Transcription

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTRADIOL; ESTROGEN RECEPTOR; HYBRID PROTEIN; NCOA2 PROTEIN, HUMAN; NUCLEAR PROTEIN; NUCLEAR RECEPTOR COACTIVATOR 2; TRANSCRIPTION FACTOR; TRANSCRIPTIONAL INTERMEDIARY FACTOR 1;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; FEMALE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN VARIANT; TANDEM REPEAT; ANIMAL; CELL CULTURE; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; GENE DELETION; HELA CELL; METABOLISM; MULTIGENE FAMILY; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE; REGULATORY SEQUENCE; TATA BOX; TRANSACTIVATION;

AMINO ACID MOTIFS; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; HELA CELLS; HUMANS; MULTIGENE FAMILY; NUCLEAR PROTEINS; NUCLEAR RECEPTOR COACTIVATOR 2; PROMOTER REGIONS (GENETICS); PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ESTROGEN; RECOMBINANT FUSION PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; SEQUENCE DELETION; TANDEM REPEAT SEQUENCES; TATA BOX; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0037188825     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(01)00673-6     Document Type: Article

References (66)

1. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
2. DNA regulatory elements for steroid hormones
3. Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain
4. Synergy between estrogen receptor a activation functions AF-1 and AF-2 mediated by transcription intermediary factor TIF2
5. Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen
6. The biology and mechanism of steroid hormone receptor interaction with the eukaryotic nucleus
7. The enhanceosome and transcriptional synergy
8. Steroid hormone regulation of specific gene expression
9. The role of estrogen response elements in expression of the Xenopus laevis vitellogenin B1 gene
10. Regulation of transcription by a protein methyltransferase
11. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase
12. A comparison of transcriptional activation by ER alpha and ER beta
13. Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors
14. Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP-1) and steroid receptor coactivator 1 (SRC-1): Multiple motifs with different binding specificities
15. Footprint analysis of estrogen receptor binding to adjacent estrogen response elements
16. Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha
17. Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain
18. The steroid and thyroid hormone receptor superfamily
19. Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor
20. Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex
21. The co-regulator exchange in transcriptional functions of nuclear receptors
22. The estrogen receptor beta-isoform (ER beta) of the human estrogen receptor modulates ER alpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens
23. GRIP-1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors
24. Repression of endogenous estrogen receptor activity in MCF-7 human breast cancer cells by dominant negative estrogen receptors
25. The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT
26. Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor
27. Synergism of closely adjacent estrogen-responsive elements increases their regulatory potential
28. A 13 bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor
29. Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-alpha and estrogen receptor-beta: Correlations with biological character and distinct differences among SRC coactivator family members
30. P300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation
31. Ligand-dependent, transcriptionally productive association of the amino- and carboxyl-terminal regions of a steroid hormone nuclear receptor
32. Localisation of the oestradiol-binding and putative DNA-binding domains of the human oestrogen receptor
33. Functional domains of the human estrogen receptor
34. Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes
35. The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18
36. Identification of constitutive and steroid-dependent transactivation domains in the mouse oestrogen receptor
37. Cooperative binding of estrogen receptor to imperfect estrogen-responsive DNA elements correlates with their synergistic hormone-dependent enhancer activity
38. The estrogen-responsive element as an inducible enhancer: DNA sequence requirements and conversion to a glucocorticoid-responsive element
39. Properties of overlapping EREs: Synergistic activation of transcription and cooperative binding of ER
40. Analysis of ligand dependence and hormone response element synergy in transcription by estrogen receptor
41. A transcriptionally active receptor mutant is a novel type of dominant negative inhibitor of estrogen action
42. Function of N-terminal transactivation domain of the estrogen receptor requires a potential-helical structure and is negatively regulated by the A domain
43. Nuclear receptor coregulators: Cellular and molecular biology
44. The carboxy-terminal F domain of the human estrogen receptor: Role in the transcriptional activity of the receptor and the effectiveness of antiestrogens as estrogen antagonists
45. Fusion estrogen receptor proteins: Toward the development of receptor-based agonist and antagonist
46. New screening methods for chemicals with hormonal activities using interaction of nuclear hormone receptor with coactivator
47. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
48. Properties of a high-affinity DNA binding site for estrogen receptor
49. Synergistic activation of transcription by the human estrogen receptor bound to tandem responsive elements
50. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
51. Differential effects of xenoestrogens on coactivator recruitment by estrogen receptor (ER) alpha and ER beta
52. Effects of multiple estrogen responsive elements, their spacing, and location on estrogen response of reporter genes
53. Cofacterdynamics and sufficiency in oestrogen receptor-mediated transcription
54. The language of covalent histone modifications
55. Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains
56. Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1
57. The human estrogen receptor has two independent nonacidic transcriptional activation functions
58. Steroid hormone receptors: Interaction with deoxyribonucleic acid and transcription factors
59. Molecular mechanisms of action of steroid/thyroid receptor superfamily members
60. The human estrogen receptor has transcriptional activator and repressor functions in the absence of ligand
61. Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions
62. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors
63. Sequence homologies in the region preceding the transcription initiation site of the liver estrogen-responsive vitellogenin and apo-VLDLII genes
64. Estrogen receptor activation function 1 works by binding p160 coactivator proteins
65. The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function
66. An N-terminal deletion mutant of estrogen receptor exhibits increased synergism with upstream activators and enhanced binding to the estrogen response element