Display of proteins on bacteria

Journal of Biotechnology

Volumn 96, Issue 2, 2002, Pages 129-154

  Samuelson, Patrik ^a   Gunneriusson, Elin ^a   Nygren, Per Åke ^a   Ståhl, Stefan ^a  

^a ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

Author keywords

Bioadsorbent; Environmental application; Gram negative bacteria; Gram positive bacteria; Microbial biocatalyst; Surface display; Vaccine delivery

Indexed keywords

ANTIGENS; BACTERIA; CLONING; ENZYMES; IMMUNOSENSORS; VACCINES;

VACCINOLOGY;

PROTEINS;

BACTERIAL VACCINE; DRUG CARRIER; DRUG VEHICLE; EPITOPE; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 41; HEPATITIS B SURFACE ANTIGEN; INVASIN; LIPOPROTEIN; MEMBRANE ANTIGEN; METAL ION; OUTER MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN A; OUTER MEMBRANE PROTEIN C; PEPTIDE LIBRARY; PROTEIN LAMB; PROTEIN OMPS; PROTEIN OPRF; PULLULANASE; UNCLASSIFIED DRUG;

BACTERIAL CELL; BIOCATALYST; BIOSENSOR; CELL SURFACE; DEVICE; DRUG DELIVERY SYSTEM; ENZYME IMMOBILIZATION; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; GUINEA PIG; IMMUNE RESPONSE; IMMUNOREACTIVITY; IN VITRO STUDY; MONKEY; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN PHOE; RABBIT; REVIEW; SALMONELLA TYPHIMURIUM; SHIGELLA DYSENTERIAE;

BACTERIAL PROTEINS; BIOTECHNOLOGY; CELL MEMBRANE; GRAM-NEGATIVE AEROBIC BACTERIA; GRAM-POSITIVE BACTERIA; MEMBRANE PROTEINS;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; POSIBACTERIA;

EID: 0037178208     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(02)00043-3     Document Type: Review

References (226)

1. Heat-stable spore-based vaccines: Surface expression of invasin-cell wall fusion proteins in Bacillus subtilis
2. Cell-cell interactions in conjugating Escherichia coli: Role of traT protein in surface exclusion
3. Use of outer membrane protein PhoE as a carrier for the transport of a foreign antigenic determinant to the cell surface of Escherichia coli K-12
4. Expression of Escherichia coli PhoE protein in avirulent Salmonella typhimurium aroA and galE strains
5. Outer membrane PhoE protein of Escherichia coli as a carrier for foreign antigenic determinants: Immunogenicity of epitopes of foot-and-mouth disease virus
6. Enhanced bioaccumulation of heavy metals by bacterial cells displaying synthetic phytochelatins
7. K88 fimbriae as carriers of heterologous antigenic determinants
8. Expression of single chain antibodies (ScFvs) for c-myc oncoprotein in recombinant Escherichia coli membranes by using the ice-nucleation protein of Pseudomonas syringae
9. Biotechnological applications of phage and cell display
10. Cloning and expression of an adhesin (AIDA-I) involved in diffuse adherence of enteropathogenic Escherichia coli
11. Functions of S-layers
12. Cell-surface display of a Pseudomonas aeruginosa strain K pilin peptide within the paracrystalline S-layer of Caulobacter crescentus
13. Yeast surface display for screening combinatorial polypeptide libraries
14. Engineered iron oxide-adhesion mutants of the Escherichia coli phage lambda receptor
15. Metal-recognition by repeating polypeptides
16. Type I secretion and multidrug efflux: Transport through the TolC channel-tunnel
17. Autolysis of Lactococcus lactis is influenced by proteolysis
18. A surface-displayed cholera toxin B peptide improves antibody responses using food-grade staphylococci for mucosal subunit vaccine delivery
19. Partial protection to respiratory syncytial virus (RSV) elicited in mice by intranasal immunization using live staphylococci with surface-displayed RSV-peptides
20. Engineering antibodies for imaging and therapy
21. Two bacteriophages which utilize a new Escherichia coli major outer membrane protein as part of their receptor
22. Phytoremediation of soil metals
23. Expression of foreign antigens on the surface of Escherichia coli by fusion to the outer membrane protein traT
24. Probing the topology of a bacterial membrane protein by genetic insertion of a foreign epitope; Expression at the cell surface
25. Presentation of two epitopes of the preS2 region of hepatitis B virus on live recombinant bacteria
26. Versatility of a vector for expressing foreign polypeptides at the surface of gram-negative bacteria
27. Permissive sites and topology of an outer membrane protein with a reporter epitope
28. A quantitative immunoassay utilizing Escherichia coli cells possessing surface-expressed single chain Fv molecules
29. Type III machines of Gram-negative bacteria: Delivering the goods
30. A yeast surface display system for the discovery of ligands that trigger cell activation
31. The cystine knot of a squash-type protease inhibitor as a structural scaffold for Escherichia coli cell surface display of conformationally constrained peptides
32. In vitro selection from protein and peptide libraries
33. Gene sequence of the lambda receptor, an outer membrane protein of E. coli K12
34. Cloning and expression in Escherichia coli K-12 of the genes for major outer membrane protein OmpA from Shigella dysenteriae, Enterobacter aerogenes, and Serratia marcescens
35. Apparent bacteriophage-binding region of an Escherichia coli K-12 outer membrane protein
36. Development of new cloning vectors for the production of immunogenic outer membrane fusion proteins in Escherichia coli
37. Screening for receptor ligands using large libraries of peptides linked to the C terminus of the lac repressor
38. Peptides on phage: A vast library of peptides for identifying ligands
39. Antibody affinity maturation using bacterial surface display
40. Quantitative analysis of the effect of the mutation frequency on the affinity maturation of single chain Fv antibodies
41. Cloning and expression in Escherichia coli of the Klebsiella pneumoniae genes for production, surface localization and secretion of the lipoprotein pullulanase
42. Genetically engineered vaccines: An overview
43. Random peptide libraries: A source of specific protein binding molecules
44. Bacterial surface display of an anti-pollutant antibody fragment
45. Vaginal immunization of Cynomolgus monkeys with Streptococcus gordonii expressing HIV-1 and HPV 16 antigens
46. Phage display of proteins
47. Baculovirus surface display: Construction and screening of a eukaryotic epitope library
48. The role of the Escherichia coli lambda receptor in the transport of maltose and maltodextrins
49. Cell-surface anchoring of proteins via glycosyl-phosphatidylinositol structures
50. Secretion and assembly of regular surface structures in Gram-negative bacteria
51. Conservation of a hexapeptide sequence in the anchor region of surface proteins from gram-positive cocci
52. Gram-positive commensal bacteria for mucosal vaccine delivery
53. Surface-associated proteins of Staphylococcus aureus: Their possible roles in virulence
54. The expression of recombinant proteins on the external surface of Escherichia coli. Biotechnological applications
55. Transport and anchoring of b-lactamase to the external surface of Escherichia coli
56. Production and fluorescence-activated cell sorting of Escherichia coli expressing a functional antibody fragment on the external surface
57. Specific adhesion and hydrolysis of cellulose by intact Escherichia coli expressing surface anchored cellulase or cellulose binding domains
58. Insertion of peptides into cell-surface-exposed areas of the Escherichia coli OmpA protein does not interfere with export and membrane assembly
59. Cell surface exposure of the outer membrane protein OmpA of Escherichia coli K-12
60. Targeting recombinant antibodies to the surface of Escherichia coli: Fusion to a peptidoglycan associated lipoprotein
61. Separation of E. coli expressing functional cell-wall bound antibody fragments by FACS
62. Display of beta-lactamase on the Escherichia coli surface: Outer membrane phenotypes conferred by Lpp′-OmpA′-beta-lactamase fusions
63. Display of heterologous proteins on the surface of microorganisms: From the screening of combinatorial libraries to live recombinant vaccines
64. Nine amino acid residues at the NH2-terminal of lipoprotein are sufficient for its modification, processing, and localization in the outer membrane of Escherichia coli
65. Staphylococcus carnosus: A new host organism for gene cloning and protein production
66. Molecular evolution of bacterial cell-surface proteins
67. Surface display of a functional single-chain Fv antibody on staphylococci
68. Affinity maturation of a Taq DNA polymerase specific affibody by helix shuffling
69. Staphylococcal surface display of immunoglobulin A (IgA)- and IgE- specific in vitro-selected binding proteins (affibodies) based on Staphylococcus aureus protein A
70. Region X, the cell-wall-attachment part of staphylococcal protein A
71. Surface display compared with periplasmic expression of a malarial antigen in Salmonella typhimurium and its implications for immunogenicity
72. Crystal structure of invasin: A bacterial integrin-binding protein
73. In vitro selection and evolution of functional proteins by using ribosome display
74. Expression of recombinant proteins on the surface of the coagulase-negative bacterium Staphylococcus xylosus
75. Surface display on gram positive bacteria
76. Antibody engineering
77. Type 1 fimbriae of Escherichia coli as carriers of heterologous antigenic sequences
78. Expression of foreign polypeptides at the Escherichia coli cell surface
79. An intelligent channel (and more)
80. Antibody phage display technology and its applications
81. Pilus and nonpilus bacterial adhesins: Assembly and function in cell recognition
82. Multiple beta 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells
83. Identification of invasin: A protein that allows enteric bacteria to penetrate cultured mammalian cells
84. Fimbriae of Bacteroides nodosus: Protein engineering of the structural subunit for the production of an exogenous peptide
85. Cell surface display of salmobin, a thrombin-like enzyme from Agkistrodon halys venom on Escherichia coli using ice nucleation protein
86. Common structural features of IgA1 protease-like outer membrane protein autotransporters [letter]
87. The flagellar filament protein
88. Surface display of Zymomonas mobilis levansucrase by using the ice-nucleation protein of Pseudomonas syringae
89. Expression of carboxymethylcellulase on the surface of Escherichia coli using Pseudomonas syringae ice nucleation protein
90. Isolation of anti-T cell receptor scFv mutants by yeast surface display
91. Cell surface display of hepatitis B virus surface antigen by using Pseudomonas syringae ice nucleation protein
92. Bacterial cell surface display of an enzyme library for selective screening of improved cellulase variants
93. Sequestration of zinc oxide by fimbrial designer chelators
94. Extracellular transport of cholera toxin B subunit using Neisseria IgA protease beta-domain: Conformation-dependent outer membrane translocation
95. Selective extracellular release of cholera toxin B subunit by Escherichia coli: Dissection of Neisseria Iga beta-mediated outer membrane transport
96. The secretion pathway of IgA protease-type proteins in gram-negative bacteria
97. Novel metal-binding proteins by design
98. Molecular characterization of pulA and its product, pullulanase, a secreted enzyme of Klebsiella pneumoniae UNF5023
99. The normally periplasmic enzyme beta-lactamase is specifically and efficiently translocated through the Escherichia coli outer membrane when it is fused to the cell-surface enzyme pullulanase
100. Enhanced bioaccumulation of heavy metal ions by bacterial cells due to surface display of short metal binding peptides
101. Bacterial adhesion: Genetics, biogenesis, and role in pathogenesis of fimbrial adhesins of Escherichia coli
102. Presentation of an antigenic determinant from hen egg-white lysozyme on the flagellar filament of Escherichia coli
103. Cell surface display of human immunodeficiency virus type 1 gp120 on Escherichia coli by using ice nucleation protein
104. The OmpS maltoporin of Vibrio cholerae as carrier of foreign epitopes
105. Characterization of adhesive epitopes with the OmpS display system
106. Systemic and mucosal immunity induced by BCG vector expressing outer-surface protein A of Borrelia burgdorferi
107. Autodisplay: Functional display of active beta-lactamase on the surface of Escherichia coli by the AIDA-I autotransporter
108. The cellular location of a foreign B cell epitope expressed by recombinant bacteria determines its T cell-independent or T cell-dependent characteristics
109. Surface expression of a protective recombinant pertussis toxin S1 subunit fragment in Streptococcus gordonii
110. Surface-displayed viral antigens on Salmonella carrier vaccine
111. Directed immobilization of recombinant staphylococci on cotton fibers by functional display of a fungal cellulose-binding domain
112. Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein
113. Surface display of functional fibronectin-binding domains on Staphylococcus carnosus
114. Genetic engineering of bacteria from managed and natural habitats
115. Bacterial surface presentation of proteins and peptides: An alternative to phage technology
116. Bioremediation of metal contamination
117. Engineering metal-binding sites in proteins
118. Expression of thioredoxin random peptide libraries on the Escherichia coli cell surface as functional fusions to flagellin: A system designed for exploring protein-protein interactions
119. Mutants that overproduce TraTp, a plasmid-specified major outer membrane protein of Escherichia coli
120. Expression of cbsA encoding the collagen-binding S-protein of Lactobacillus crispatus JCM5810 in Lactobacillus casei ATCC 393(T)
121. A Bacillus subtilis dipeptide transport system expressed early during sporulation
122. Autodisplay: One-component system for efficient surface display and release of soluble recombinant proteins from Escherichia coli
123. New applications for biocatalysts
124. Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections
125. Synthetic recombinant vaccine expressing influenza haemagglutinin epitope in Salmonella flagellin leads to partial protection in mice
126. Mucosal and systemic immune responses to a recombinant protein expressed on the surface of the oral commensal bacterium Streptococcus gordonii after oral colonization
127. Commensal bacteria as vectors for mucosal vaccines against sexually transmitted diseases: Vaginal colonization with recombinant streptococci induces local and systemic antibodies in mice
128. Selection of cadmium specific hexapeptides and their expression as OmpA fusion proteins in Escherichia coli
129. Live bacterial vaccines: Environmental aspects
130. Lactic acid bacteria as live vaccines
131. Production and cell surface anchoring of functional fusions between the SLH motifs of the Bacillus anthracis S-layer proteins and the Bacillus subtilis levansucrase
132. Cell surface-exposed tetanus toxin fragment C produced by recombinant Bacillus anthracis protects against tetanus toxin
133. Bacterial SLH domain proteins are non-covalently anchored to the cell surface via a conserved mechanism involving wall polysaccharide pyruvylation
134. Characterization and expression of the structural gene for pullulanase, a maltose-inducible secreted protein of Klebsiella pneumoniae
135. Secretion of fructosyltransferase by Streptococcus salivarius involves the sucrose-dependent release of the cell-bound form
136. A comparative study on the genes for three porins of the Escherichia coli outer membrane. DNA sequence of the osmoregulated ompC gene
137. Plasmid-determined resistance to serum bactericidal activity: A major outer membrane protein, the traT gene product, is responsible for plasmid-specified serum resistance in Escherichia coli
138. Escherichia coli K-12 outer membrane protein (OmpA) as a bacteriophage receptor: Analysis of mutant genes expressing altered proteins
139. Bacteriophage receptor area of outer membrane protein OmpA of Escherichia coli K-12
140. Biosensor for direct determination of organophosphate nerve agents using recombinant Escherichia coli with surface-expressed organophosphorus hydrolase. 2. Fiber-optic microbial biosensor
141. Biosensor for direct determination of organophosphate nerve agents using recombinant Escherichia coli with surface-expressed organophosphorus hydrolase. 1. Potentiometric microbial electrode
142. Expression of random peptide fused to invasin on bacterial cell surface for selection of cell-targeting peptides
143. Proteolytic cleavage and cell wall anchoring at the LPXTG motif of surface proteins in gram-positive bacteria
144. Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope
145. Immune response to cholera toxin epitope inserted in Salmonella flagellin
146. Expression and immunogenicity of an 18-residue epitope of HIV1 gp41 inserted in the flagellar protein of a Salmonella live vaccine
147. Topology of the membrane protein LamB by epitope tagging and a comparison with the X-ray model
148. Cell-surface display of heterologous epitopes on Staphylococcus xylosus as a potential delivery system for oral vaccination
149. Hydrophobicity engineering to facilitate surface display of heterologous gene products on Staphylococcus xylosus
150. Chromosomal sequencing using a PCR-based biotin-capture method allowed isolation of the complete gene for the outer membrane protein A of Klebsiella pneumoniae
151. Molecular basis of bacterial outer membrane permeability
152. Binding proteins selected from combinatorial libraries of an α-helical bacterial receptor domain
153. Factors affecting the immunogenicity of tetanus toxin fragment C expressed in Lactococcus lactis
154. Scaffolds for engineering novel binding sites in proteins
155. Immunization of mice by oral colonization with live recombinant commensal streptococci
156. Function-based isolation of novel enzymes from a large library
157. Bacterial resistance to ultrasonic waves under pressure at nonlethal (manosonication) and lethal (manothermosonication) temperatures
158. Chimeric fimbrial vaccines
159. Chimeric FimH adhesin of type 1 fimbriae: A bacterial surface display system for heterologous sequences
160. The product of the F sex factor traT surface exclusion gene is a lipoprotein
161. Cell wall anchoring of the Streptococcus pyogenes M6 protein in various lactic acid bacteria
162. Expression of viral hemagglutinin on the surface of E. coli
163. Type III export: New uses for an old pathway
164. Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease
165. Delivery and expression of a heterologous antigen on the surface of streptococci
166. Human T-helper cell recognition of an immunodominant epitope of HIV-1 gp120 expressed on the surface of Streptococcus gordonii
167. Unipolar reorganization of F-actin layer at bacterial division and bundling of actin filaments by plastin correlate with movement of Shigella flexneri within HeLa cells
168. Polymeric display of immunogenic epitopes from herpes simplex virus and transmissible gastroenteritis virus surface proteins on an enteroadherent fimbria
169. Phytoremediation of metals: Using plants to remove pollutants from the environment
170. The cell-bound fructosyltransferase of Streptococcus salivarius: The carboxyl terminus specifies attachment in a Streptococcus gordonii model system
171. Biodegradation of organophosphorus pesticides by surface-expressed organophosphorus hydrolase [see comments]
172. Development of transgenic yellow poplar for mercury phytoremediation
173. Cell surface display of recombinant proteins on Staphylococcus carnosus
174. Staphylococcal surface display of metal-binding polyhistidyl peptides
175. Biology of type II secretion
176. Secretion of recombinant proteins by Gram-negative bacteria
177. Use of peptide libraries to map the substrate specificity of a peptide-modifying enzyme: A 13 residue consensus peptide specifies biotinylation in Escherichia coli
178. Heterobinary adhesins based on the Escherichia coli FimH fimbrial protein
179. Bioaccumulation of heavy metals by fimbrial designer adhesins
180. Structural basis for sugar translocation through maltoporin channels at 3.1 Å resolution
181. Sorting of protein A to the staphylococcal cell wall
182. Cell wall sorting signals in surface proteins of gram-positive bacteria
183. Structure of the cell wall anchor of surface proteins in Staphylococcus aureus
184. Surface expression of malarial antigens in Salmonella typhimurium: Induction of serum antibody response upon oral vaccination of mice
185. Yeast expressing hepatitis B virus surface antigen determinants on its surface: Implications for a possible oral vaccine
186. Matrices and activation methods for cell adhesion/immobilization studies
187. Display of green fluorescent protein on Escherichia coli cell surface
188. Cell surface display of organophosphorus hydrolase using ice nucleation protein
189. Engineered protein scaffolds for molecular recognition
190. Phage display
191. Enhanced metalloadsorption of bacterial cells displaying poly-His peptides
192. Metalloadsorption by Escherichia coli cells displaying yeast and mammalian metallothioneins anchored to the outer membrane protein LamB
193. Bacterial surface display: Trends and progress
194. Development of non-pathogenic staphylococci as vaccine delivery vehicles
195. Staphylococcal surface display and its applications
196. Characterization of Escherichia coli expressing an Lpp′OmpA(46-159)- PhoA fusion protein localized in the outer membrane
197. LamB as a carrier molecule for the functional exposition of IgG-binding domains of the Staphylococcus aureus protein A at the surface of Escherichia coli K12
198. Functional display of a heterologous protein on the surface of Lactococcus lactis by means of the cell wall anchor of Staphylococcus aureus protein A
199. Authentic display of a cholera toxin epitope by chimeric type 1 fimbriae: Effects of insert position and host background
200. Protective immunity elicited by recombinant bacille Calmette-Guerin (BCG) expressing outer surface protein A (OspA) lipoprotein: A candidate Lyme disease vaccine
201. Protective immunity elicited by rBCG vaccines
202. In vivo immobilization of enzymatically active polypeptides on the cell surface of Staphylococcus carnosus
203. Construction of stable LamB-Shiga toxin B subunit hybrids: Analysis of expression in Salmonella typhimurium aroA strains and stimulation of B subunit-specific mucosal and serum antibody responses
204. Extracellular transport of VirG protein in Shigella
205. Construction of a multihybrid display system: Flagellar filaments carrying two foreign adhesive peptides
206. The TraT lipoprotein as a vehicle for the transport of foreign antigenic determinants to the cell surface of Escherichia coli K12: Structure-function relationships in the TraT protein
207. On some genetic aspects of phage lambda resistance in E. coli K12
208. Cloning of DNA sequences encoding foreign peptides and their expression in the K88 pili
209. Expression of the Yersinia pestis capsular antigen (F1 antigen) on the surface of an aroA mutant of Salmonella typhimurium induces high levels of protection against plague
210. Anchor structure of staphylococcal surface proteins. A branched peptide that links the carboxyl terminus of proteins to the cell wall
211. Complete sequence of the staphylococcal gene encoding protein A
212. Engineering a mouse metallothionein on the cell surface of Ralstonia eutropha CH34 for immobilization of heavy metals in soil
213. A comparative study on the phoE genes of three enterobacterial species. Implications for structure-function relationships in a pore-forming protein of the outer membrane
214. Expression of foreign epitopes in P-fimbriae of Escherichia coli
215. Translocation of proteins across the cell envelope of Gram-positive bacteria
216. Biosorption of heavy metals
217. Generation of metal-binding staphylococci through surface display of combinatorially engineered cellulose-binding domains
218. Bacterial proteins binding to the mammalian extracellular matrix
219. Functional expression of adhesive peptides as fusions to Escherichia coli flagellin
220. Compartmentalization of defined epitopes expressed in Escherichia coli has only a minor influence on efficiency of phagocytic processing for presentation by class I and class II major histocompatibility complex molecules to T cells
221. Bacterial flagellar filaments and their component flagellins
222. The use of mRNA display to select high-affinity protein-binding peptides
223. Pseudomonas aeruginosa outer membrane protein OprF as an expression vector for foreign epitopes: The effects of positioning and length on the antigenicity of the epitope
224. Expression of immunogenic epitopes of hepatitis B surface antigen with hybrid flagellin proteins by a vaccine strain of Salmonella
225. Display of polyhistidine peptides on the Escherichia coli cell surface by using outer membrane protein C as an anchoring motif