Authentic display of a cholera toxin epitope by chimeric type 1 fimbriae: Effects of insert position and host background

Microbiology

Volumn 143, Issue 6, 1997, Pages 2027-2038

  Stentebjerg Olesen, Bodil ^a   Pallesen, Lars ^a,c   Jensen, Lars Bogø ^a   Christiansen, Gunna ^b   Klemm, Per ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c STATENS SERUM INSTITUT   (Denmark)

Author keywords

Chimeric proteins; Effect of host background; Surface display of foreign epitopes; Type 1 fimbriae

Indexed keywords

CHIMERIC PROTEIN; CHOLERA TOXIN B SUBUNIT; EPITOPE; MEMBRANE ANTIGEN; STRUCTURAL PROTEIN;

ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; ESCHERICHIA COLI; FIMBRIA; GENE CLUSTER; GENE INSERTION; IMMUNIZATION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RABBIT; RECOMBINANT GENE; RESTRICTION SITE; SITE DIRECTED MUTAGENESIS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; ORYCTOLAGUS CUNICULUS;

EID: 0030841922     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-143-6-2027     Document Type: Article

References (34)

1. Birnboim, H. C. & Doly, J. (1979). A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acid Res 7, 1513-1523.
2. Blum, G., Marre, R. & Hacker, J. (1995). Properties of Escherichia coli strains of serotype O6. Infection 23, 234-236.
3. Brinton, C. C., Jr (1965). The structure, function, synthesis and genetic control of bacterial pili and a molecular model for DNA and RNA transport in Gram negative bacteria. Trans NY Acad Sci 27, 1003-1054.
4. Dodd, D. C. & Eisenstein, B. I. (1984). Dependence of secretion and assembly of type 1 fimbrial subunits on normal protein export. J Bacteriol 159, 1077-1079.
5. Duguid, J. P. & Old, D. C. (1980). Adhesive properties of Enterobacteriaceae. In Receptors and Recognition, series B, vol. 6, pp. 186-217. Edited by E. Beachey. London: Chapman & Hall.
6. Hedegaard, L. & Klemm, P. (1989). Type 1 fimbriae of Escherichia coli as carriers of heterologous antigenic sequences. Gene 85, 115-124.
7. Hormaeche, C. E., Dougan, G. & Chatfield, S. N. (1992). Live attenuated salmonella: oral vaccines for salmonellosis and combined vaccines carrying heterologous antigens. In The Release of Genetically Modified Microorganisms, pp. 71-83. Edited by D. E. S. Stewart-Tull & M. Sussmann. New York: Plenum Press.
8. Hultgren, S. J., Abraham, S. N., Caparon, M., Falk, P., St Geme, J. W., III & Normark, S. (1993). Pilus and non pilus bacterial adhesins: assembly and function in cell recognition. Cell 73, 887-901.
9. Jacob, O. C., Sela, M. & Arnon, R. (1983). Antibodies against synthetic peptides of the B subunit of cholera toxin: crossreaction and neutralization of the toxin. Proc Natl Acad Sci USA 80, 7611-7615.
10. Jones, C. H., Pinkner, J. S., Nicholes, A. V., Slonim, L. N., Abraham, S. N. & Hultgren, S. J. (1993). FimC is periplasmic PapD-like chaperone that directs assembly of type 1 pili in bacteria. Proc Natl Acad Sci USA 90, 8397-8401.
11. Klemm, P. (1984). The fimA gene encoding the type 1 fimbrial subunit of Escherichia coli, nucleotide sequence and primary structure of the protein. Eur J Biochem 143, 395-399.
12. Klemm, P. (1992). FimC, a chaperone-like periplasmic protein of Escherichia coli involved in biogenesis of type 1 fimbriae. Res Microbiol 143, 831-838.
13. Klemm, P. & Christiansen, G. (1987). Three fim genes required for the regulation of length and mediation of adhesion of Escherichia coli type 1 fimbriae. Mol Gen Genet 208, 439-445.
14. Klemm, P. & Christiansen, G. (1990). The fimD gene required for cell surface localization of Escherichia coli type 1 fimbriae. Mol Gen Genet 220, 334-338.
15. Klemm, P. & Krogfelt, K. A. (1994). Type 1 fimbriae of Escherichia coli. In Fimbriae, Adhesion, Genetics, Biogenesis and Vaccines, pp. 9-28. Edited by P. Klemm. Boca Raton, FL: CRC Press.
16. Klemm, P., Jørgensen, B. J., van Die, I., de Ree, H. & Bergmans, H. (1985). The fim genes responsible for synthesis of type 1 fimbriae in Escherichia coli. Mol Gen Genet 199, 410-414.
17. Klemm, P., Christiansen, G., Kreft, B., Marre, R. & Bergmans, H. (1994). Reciprocal exchange of minor components of type 1 and F1C fimbriae results in hybrid organelles with changed receptor specificity. J Bacteriol 176, 2227-2234.
18. Krogfelt, K. A. (1991). Bacterial adhesion: genetics, biogenesis, and role in pathogenesis of fimbrial adhesins of Escherichia coli. Rev Infect Dis 13, 721-735.
19. Krogfelt, K. A. & Klemm, P. (1988). Investigation of minor components of Escherichia coli type 1 fimbriae: protein chemical and immunological aspects. Microb Pathog 4, 231-238.
20. Krogfelt, K. A., Bergmans, H. & Klemm, P. (1990). Direct evidence that the FimH protein is the mannose specific adhesin of Escherichia coli type 1 fimbriae. Infect Immun 58, 1995-1998.
21. Leclerc, C., Charbit, A., Martineau, P., Deriaud, E. & Hofnung, M. (1991). The cellular location of a foreign B cell epitope expressed by recombinant bacteria determines its T cell-dependent characteristics. J Immunol 147, 3545-3550.
22. Levine, M. M., Giron, J. & Noriega, F. (1994). Fimbrial vaccines. In Fimbriae, Adhesion, Genetics, Biogenesis and Vaccines, pp. 271-286. Edited by P. Klemm. Boca Raton, FL: CRC Press.
23. McMichael, J. C. & Ou, J. T. (1979). Structure of common pili from Escherichia coli. J Bacteriol 138, 969-975.
24. MI pentasaccharide. Protein Sci 3, 166-175.
25. Moon, H. W. & Bunn, T. O. (1993). Vaccines for preventing enterotoxigenic Escherichia coli infections in farm animals. Vaccine 11, 213-219.
26. Newton, S. M. C., Jacob, C. O. & Stocker, B. A. D. (1989). Immune response to cholera toxin epitope inserted into Salmonella flagellin. Science 244, 70-72.
27. Pallesen, L. & Klemm, P. (1994). Chimeric fimbrial vaccines. In Fimbriae, Adhesion, Genetics, Biogenesis and Vaccines, pp. 289-294. Edited by P. Klemm. Boca Raton, FL: CRC Press.
28. Pallesen, L., Poulsen, L. K., Christiansen, G. & Klemm, P. (1995). Chimeric FimH adhesin of type 1 fimbriae: a bacterial display system for heterologous sequences. Microbiology 141, 2839-2848.
29. Pugsley, A. P. (1993). The complete secretory pathway in Gram-negative bacteria. Microbiol Rev 57, 50-108.
30. Russell, P. V. & Orndorff, P. E. (1992). Lesions in two Escherichia coli type 1 pilus genes alter pilus number and length without affecting receptor binding. J Bacteriol 174, 5923-5935.
31. Sanger, F., Nicklen, S. & Coulson, A. R. (1977). DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74, 5463-5467.
32. Schembri, M., Pallesen, L., Connell, H. & Klemm, P. (1996). Linker insertion mutagenesis of the FimH adhesin of type 1 fimbriae in an Escherichia coli fimH-null host. FEMS Microbiol Lett 137, 257-263.
33. Shoham, M., Schert, T., Anglister, J., Levitt, M., Merrit, E. A. & Hol, W. G. J. (1995). Structural diversity in a conserved cholera toxin epitope involved in ganglioside binding. Protein Sci 4, 841-848.
34. Wu, J. Y., Newton, S., Judd, A., Stocker, B. & Robinson, W. S. (1989). Expression of immunogenic epitopes of hepatitis B surface antigen with hybrid flagellin proteins by a vaccine strain of Salmonella. Proc Natl Acad Sci USA 86, 4726-4730.