Further studies on conformationally constrained tricyclic tropane analogues and their uptake inhibition at monoamine transporter sites: Synthesis of (z)-9-(substituted arylmethylene)-7-azatricyclo[4.3.1.03,7]decanes as a Novel class of serotonin transporter inhibitors

Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2002, Pages 1930-1941

  Zhang, Ao ^a   Zhou, Guochun ^a   Hoepping, Alexander ^a   Mukhopadhyaya, Jayanta ^a   Johnson, Kenneth M ^b   Zhang, Mei ^b   Kozikowski, Alan P ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

10 (BENZOYLOXYMETHYL) 9 (3 CHLORO 4 IODOBENZYLIDENE) 7 AZATRICYCLO[4.3.1.0 3,7]DECANE; 10 (BENZOYLOXYMETHYL) 9 (3 CHLORO 4 METHYLBENZYLIDINE) 7 AZATRICYCLO[4.3.1.0 3,7]DECANE; 10 (BENZOYLOXYMETHYL) 9 (4 BROMO 3 CHLOROBENZYLIDENE) 7 AZATRICYCLO[4.3.1.0 3,7]DECANE; 9 (3,4 DICHLOROBENZYLIDENE) 10 PROPANOYL 7 AZATRICYCLO[4.3.1.0 3,7]DECANE; 9 (4 BROMOBENZYLIDENE) 7 AZATRICYCLO[4.3.1.0]DECANE 10 CARBOXYLIC ACID METHYL ESTER; 9 (4 ISOPROPYLBENZYLIDENE) 7 AZATRICYCLO[4.3.1.0]DECANE 10 CARBOXYLIC ACID METHYL ESTER; COCAINE; DOPAMINE; FLUOXETINE; NORADRENALIN; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; TRITIUM; TROPANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; COCAINE DEPENDENCE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; SEROTONINERGIC SYSTEM;

ANIMALS; BRAIN; BRIDGED COMPOUNDS; CARRIER PROTEINS; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HETEROCYCLIC COMPOUNDS, 3-RING; LIGANDS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR CONFORMATION; NERVE TISSUE PROTEINS; NOREPINEPHRINE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; RATS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SYMPORTERS; SYNAPTOSOMES; TROPANES;

EID: 0037171834     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0105373     Document Type: Article

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