Synthesis of 3β-aryl-8-azabicyclo[3.2.1]octanes with high binding affinities and selectivities for the serotonin transporter site

Journal of Medicinal Chemistry

Volumn 39, Issue 13, 1996, Pages 2554-2558

  Davies, Huw M L ^a   Kuhn, Lisa A ^b   Thornley, Craig ^b   Matasi, Julius J ^a   Sexton, Tammy ^c   Childers, Steven R ^c  

^a UNIVERSITY AT BUFFALO   (United States)

^b WAKE FOREST UNIVERSITY   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3BETA [4 (1 METHYLETHYNYL)PHENYL] 2BETA PROPANOYL 8 AZABICYCLO[3.2.1]OCTANE; 8 AZABICYCLO[3.2.1]OCTANE DERIVATIVE; OCTANE; SEROTONIN TRANSPORTER; TROPANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DEMETHYLATION; DOPAMINE UPTAKE; DOPAMINERGIC TRANSMISSION; DRUG POTENCY; DRUG SYNTHESIS; MEMBRANE TRANSPORT; NONHUMAN; PROTEIN MODIFICATION; RAT; SEROTONINERGIC TRANSMISSION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; CARRIER PROTEINS; COCAINE; CORPUS STRIATUM; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FLUOXETINE; FRONTAL LOBE; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR STRUCTURE; NERVE TISSUE PROTEINS; NOREPINEPHRINE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PAROXETINE; RATS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SYMPORTERS; TROPANES;

EID: 0029992705     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9600508     Document Type: Article

References (22)

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