(1α,2β,3β,4α)-1,2-Bis[[N-propyl-n-(4-phen oxybenzyl)amino]carbonyl]cyclobutane-3,4-diearboxylic acid (A-87049): A novel potent squalene synthase inhibitor

Journal of Medicinal Chemistry

Volumn 40, Issue 14, 1997, Pages 2123-2125

  Fung, A K L ^a   Baker, W R ^a   Fakhoury, S ^a   Stein, H H ^a   Cohen, J ^a   Donner, B G ^a   Garvey, D S ^a   Spina, K P ^a   Rosenberg, S H ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1ALPHA,2BETA BIS[[N PROPYL N (4 PHENOXYBENZYL)AMINO]CARBONYL] 3BETA,4ALPHA CYCLOBUTANEDICARBOXYLIC ACID; 1ALPHA,2BETA BIS[[N PROPYL N (4 PHENOXYBENZYL)AMINO]CARBONYL]CYCLOBUTANE 3BETA,4ALPHA DICARBOXYLIC ACID; ANTILIPEMIC AGENT; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; SQUALENE SYNTHASE INHIBITOR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; DRUG POTENCY; HYPERCHOLESTEROLEMIA; LIPID BLOOD LEVEL; LIVER MICROSOME; MONKEY; NONHUMAN; NOTE; ORAL DRUG ADMINISTRATION; RAT;

AMIDES; ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DICARBOXYLIC ACIDS; ENZYME INHIBITORS; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; FEMALE; INDICATORS AND REAGENTS; LOVASTATIN; MACACA FASCICULARIS; MALE; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030790782     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970058x     Document Type: Note

References (20)